Genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population

Zuhal Uçkun Şahinoğulları; Necmiye Canacankatan; Mehmet Canacankatan

Genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population

Abstract

Many xenobiotic and endogenous compounds are transported from blood into hepatocytes mediated by organic anion transporter protein (OATP1B1), which is encoded by solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene. Genetic polymorphisms in SLCO1B1 gene can affect in pharmacokinetics of most compounds and may cause changes in drug efficacy and advers reactions. Thus, genetic polymorphism analysis of genes that may affect the pharmacokinetics of compounds is extremely important. The goal of this study was to determine the genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population and also to compare our results with the findings of other previously reported populations. Genotyping analyses of SLCO1B1 g.89595 T>C polymorphism was carried out in 68 healthy Turkish volunteers by a polymerase chain reaction restriction fragment length polymorphism method. The frequencies of the TT, TC, and CC genotypes were 77.9, 19.1 and 3.0, respectively. Also, the frequencies of T and C alleles were 87.5 and 12.5, respectively. The genotype frequencies were consistent with Hardy–Weinberg equilibrium. The results of the study are compared with those of other ethnic groups, and they displayed pronounced ethnic group differences, especially East Asian and Southeast ancestry. The detection of SLCO1B1 polymorphisms may ensure benefits for adjustment of dosage regimens of some drugs and protecting from and/or decreasing adverse events, and also for future studies concerning SLCO1B1 transporter and its polymorphisms.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Toxicology

Journal Section

Research Article

Authors

Zuhal Uçkun Şahinoğulları ^*
Türkiye

Necmiye Canacankatan
Türkiye

Mehmet Canacankatan This is me
Türkiye

Publication Date

June 27, 2025

Submission Date

July 23, 2019

Acceptance Date

October 28, 2019

Published in Issue

Year 2019 Volume: 23 Number: 6

IZ

https://izlik.org/JA28RK77CJ

Cite

RIS / Bibtex

APA

Uçkun Şahinoğulları, Z., Canacankatan, N., & Canacankatan, M. (2025). Genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population. Journal of Research in Pharmacy, 23(6), 1149-1156. https://izlik.org/JA28RK77CJ

AMA

1.Uçkun Şahinoğulları Z, Canacankatan N, Canacankatan M. Genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population. J. Res. Pharm. 2025;23(6):1149-1156. https://izlik.org/JA28RK77CJ

Chicago

Uçkun Şahinoğulları, Zuhal, Necmiye Canacankatan, and Mehmet Canacankatan. 2025. “Genotype and Allele Frequencies of SLCO1B1 G.89595 T>C Polymorphism in a Healthy Turkish Population”. Journal of Research in Pharmacy 23 (6): 1149-56. https://izlik.org/JA28RK77CJ.

EndNote

Uçkun Şahinoğulları Z, Canacankatan N, Canacankatan M (July 1, 2025) Genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population. Journal of Research in Pharmacy 23 6 1149–1156.

IEEE

[1]Z. Uçkun Şahinoğulları, N. Canacankatan, and M. Canacankatan, “Genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population”, J. Res. Pharm., vol. 23, no. 6, pp. 1149–1156, July 2025, [Online]. Available: https://izlik.org/JA28RK77CJ

ISNAD

Uçkun Şahinoğulları, Zuhal - Canacankatan, Necmiye - Canacankatan, Mehmet. “Genotype and Allele Frequencies of SLCO1B1 G.89595 T>C Polymorphism in a Healthy Turkish Population”. Journal of Research in Pharmacy 23/6 (July 1, 2025): 1149-1156. https://izlik.org/JA28RK77CJ.

JAMA

1.Uçkun Şahinoğulları Z, Canacankatan N, Canacankatan M. Genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population. J. Res. Pharm. 2025;23:1149–1156.

MLA

Uçkun Şahinoğulları, Zuhal, et al. “Genotype and Allele Frequencies of SLCO1B1 G.89595 T>C Polymorphism in a Healthy Turkish Population”. Journal of Research in Pharmacy, vol. 23, no. 6, July 2025, pp. 1149-56, https://izlik.org/JA28RK77CJ.

Vancouver

1.Zuhal Uçkun Şahinoğulları, Necmiye Canacankatan, Mehmet Canacankatan. Genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population. J. Res. Pharm. [Internet]. 2025 Jul. 1;23(6):1149-56. Available from: https://izlik.org/JA28RK77CJ