Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

Dilek Özbeyli; Gizem Yarimbaş; Büşra Ertaş; Ali Şen; Selin Şakarcan; Göksel Şener

Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

Abstract

Obesity causes cognitive weakening and increases the risk of neurodegenerative diseases. Myrtus communis extract (MC) has anti-inflammatory and antioxidant properties. In this study, it is aimed to investigate the effects of Myrtus communis on oxidative brain damage caused by a high-fat diet (HFD), using behavioral and biochemical parameters. Twenty‐ four Wistar albino rats (200–250 g) were divided into three groups. The control group (C) received a standard diet, while HFD groups were received HFD for 16 weeks. MC (100 mg/kg, oral) was given to the HFD + MC group for the last 4 weeks. At the end of the study, the novel object recognition test (NORT) was performed and the hippocampus and blood samples were collected. Acetylcholinesterase (AChE) and Na+/K+‐ ATPase activities, malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and reduced glutathione (GSH) levels were measured in the hippocampal samples and cholesterol levels were analyzed in sera. Findings have shown that NORT performance of the HFD group was reduced, while administration of MC prevents this reduction and in parallel, increased AChE and decreased Na⁺ /K⁺ -ATPase activities were ameliorated by administration of MC. Increased MDA and 8-OHdG levels observed in the HFD group, were decreased in the MC treated HFD group. Our results point out that MC has ameliorative effects on hippocampal oxidative stress and cognitive impairment in high fat nutritioninduced obesity.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Dilek Özbeyli
Türkiye

Gizem Yarimbaş This is me
Türkiye

Büşra Ertaş
Türkiye

Ali Şen
Türkiye

Selin Şakarcan This is me
United States

Göksel Şener ^*
Türkiye

Publication Date

June 27, 2025

Submission Date

July 30, 2020

Acceptance Date

September 1, 2020

Published in Issue

Year 2020 Volume: 24 Number: 6

IZ

https://izlik.org/JA89RP69TX

Cite

RIS / Bibtex

APA

Özbeyli, D., Yarimbaş, G., Ertaş, B., Şen, A., Şakarcan, S., & Şener, G. (2025). Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function. Journal of Research in Pharmacy, 24(6), 865-873. https://izlik.org/JA89RP69TX

AMA

1.Özbeyli D, Yarimbaş G, Ertaş B, Şen A, Şakarcan S, Şener G. Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function. J. Res. Pharm. 2025;24(6):865-873. https://izlik.org/JA89RP69TX

Chicago

Özbeyli, Dilek, Gizem Yarimbaş, Büşra Ertaş, Ali Şen, Selin Şakarcan, and Göksel Şener. 2025. “Myrtus Communis Extract Ameliorates High-Fat Diet Induced Brain Damage and Cognitive Function”. Journal of Research in Pharmacy 24 (6): 865-73. https://izlik.org/JA89RP69TX.

EndNote

Özbeyli D, Yarimbaş G, Ertaş B, Şen A, Şakarcan S, Şener G (June 1, 2025) Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function. Journal of Research in Pharmacy 24 6 865–873.

IEEE

[1]D. Özbeyli, G. Yarimbaş, B. Ertaş, A. Şen, S. Şakarcan, and G. Şener, “Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function”, J. Res. Pharm., vol. 24, no. 6, pp. 865–873, June 2025, [Online]. Available: https://izlik.org/JA89RP69TX

ISNAD

Özbeyli, Dilek - Yarimbaş, Gizem - Ertaş, Büşra - Şen, Ali - Şakarcan, Selin - Şener, Göksel. “Myrtus Communis Extract Ameliorates High-Fat Diet Induced Brain Damage and Cognitive Function”. Journal of Research in Pharmacy 24/6 (June 1, 2025): 865-873. https://izlik.org/JA89RP69TX.

JAMA

1.Özbeyli D, Yarimbaş G, Ertaş B, Şen A, Şakarcan S, Şener G. Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function. J. Res. Pharm. 2025;24:865–873.

MLA

Özbeyli, Dilek, et al. “Myrtus Communis Extract Ameliorates High-Fat Diet Induced Brain Damage and Cognitive Function”. Journal of Research in Pharmacy, vol. 24, no. 6, June 2025, pp. 865-73, https://izlik.org/JA89RP69TX.

Vancouver

1.Dilek Özbeyli, Gizem Yarimbaş, Büşra Ertaş, Ali Şen, Selin Şakarcan, Göksel Şener. Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function. J. Res. Pharm. [Internet]. 2025 Jun. 1;24(6):865-73. Available from: https://izlik.org/JA89RP69TX