Development and characterization of camphor-loaded ozonated olive oil nanoemulsions

Year 2020, Volume: 24 Issue: 6, 935 - 942, 27.06.2025

Tahir Emre Yalçın Sevgi Takka

https://doi.org/10.35333/jrp.2020.253

https://izlik.org/JA48DZ53ST

Abstract

The purpose of present study is to prepare and characterize camphor-loaded ozonated olive oil nanoemulsions (NEs). In this study, olive oils were ozonated with different times (up to 24 h) and their viscosities were examined. NEs were prepared by high-energy ultrasonication technique and characterized according to droplet size distribution, zeta potential, microscopic evaluation, and storage stability. The effect of oil phase/aqueous phase volume ratio, sonication time, and co-solvent (glycerol) on formulations were evaluated. 6 h ozonated olive oil was chosen for developing NEs due to its liquid form and viscosity (189 mPas). The obtained camphor-loaded NEs (with or without glycerol) had nearly 300 nm droplet size with negative zeta potential. Microscopic analysis revealed the spherical shape of droplets. The long-term stability tests showed that camphor-loaded NEs with glycerol were more stable than NEs without glycerol at 4 °C and 25 °C. According to the results, ozonated olive oil based NEs with glycerol might be promising nanosystems for topical delivery of camphor.

Keywords

Camphor , nanoemulsions , ozonated olive oil , long-term stability

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