Recent progress in the development of localized drug delivery systems for oral mucosal disorders using mucoadhesive patches

Year 2025, Volume: 29 Issue: 3, 1350 - 1366, 04.06.2025

Tuna Barkin Tüküç Emine Alarçin , Ayça Bal Öztürk

https://doi.org/10.12991/jrespharm.1712426

Abstract

Oral diseases are becoming increasingly prevalent worldwide, posing a significant challenge in treating recurrent conditions due to the wet and movable environment of the oral cavity. This environment reduces the residence time of formulations, making it difficult to effectively treat oral diseases. To address this issue, the use of mucoadhesive systems could be a beneficial strategy to prevent accidental swallowing and wash-off. Various approaches have been suggested to provide mucoadhesion and mucosal penetration, including the use of naturally derived or synthetic polymers, bio-inspired materials, or thiomers. These biocompatible oral mucoadhesive systems with strong wet adhesion offer a promising opportunity for drug delivery applications. In this review, we have focused on current oral mucoadhesive systems that improve local treatment of oral diseases. We begin by providing a brief overview of the structural properties of the oral mucosa, permeability considerations, and the mechanism of mucoadhesion. We then provide examples of innovative materials commonly used in oral mucoadhesive drug delivery systems for local therapy.

Keywords

Oral disease , mucoadhesion , mucoadhesive polymers , thiolated polymers , mussel inspired polymers

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