NOSE-TO-BRAIN DRUG DELIVERY OF NANOFORMULATIONS: PREPARATION AND IN VITRO EVALUATION

Işık Çelikkol; Özge Eşim; Canan Hasçiçek

NOSE-TO-BRAIN DRUG DELIVERY OF NANOFORMULATIONS: PREPARATION AND IN VITRO EVALUATION

Abstract

Central nervous system (CNS)-related diseases constitute 6.3% of all diseases globally. Because of the increased prevalence of CNS-diseases, the requirement for novel strategies for delivering therapeutics across the blood-brain barrier (BBB) has arisen [1]. The management of CNS diseases is challenging. BBB is the main obstacle preventing traditional therapeutics from reaching the CNS. Researchers have developed strategies that can deliver therapeutics to the CNS, such as (1) bypassing BBB by using other administration routes, (2) transient disrupting BBB by physical or biochemical approaches, (3) enabling penetration into BBB by administration of endogenous transporters and receptors, (4) inhibition of efflux transporters, (5) using drug carriers [2]. Nose-to-brain route has been considered a viable alternative to deliver therapeutics to the brain. Intranasal delivery to the CNS has some advantages including noninvasiveness, minimized systemic exposure, rapid transport from the nasal mucosa to the brain and prompt efficiency, elimination of the first-pass effect, lower side effects [3]. Although it has many advantages, mucociliary clearance, and limited absorption from the nasal epithelium are also disadvantages [4]. Due to the disadvantages of intranasal administration, various approaches are needed to increase drug penetration. Nanotechnology-based drug delivery systems including nanoparticles, in situ gels and liposomes have been designed to make use of the superiorities nanocarriers, such as extended retention at the nasal mucosa, nanoranged size, and ability to open the tight junctions [2, 3]. In this study, migraine, a chronic neurological disease, was chosen as a model, and dexketoprofen trometamol (DXT) loaded chitosan- and chitosan/alginate nanoparticles were developed and characterized for treatment of migraine. Chitosan has been chosen as an ideal polymer for targeting the brain via intranasal therapy due to its capacity to generate inter-/intramolecular bonding and polycationic surface as a result of its amino groups. The developed nanoparticle formulations were formulated into a chitosan-based hydrogel formulation and the mucoadhesive properties of the formulations were investigated.

Keywords

References

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[2] Sun C, Ding Y, Zhou L, Shi D, Sun L, Webster TJ, Shen Y. Noninvasive nanoparticle strategies for brain tumor targeting. Nanomed-Nanotechnol Biol Med. 2017; 13(8):2605-2621. [Crossref]
[3] Awad R, Avital A, Sosnik A. Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders. Acta Pharm Sin B. 2023;13(5):1866-1886. [Crossref]
[4] Karavasili C, Fatouros DG. Smart materials: In situ gel-forming systems for nasal delivery. Drug Discov Today. 2016; 21(1):157-166. [Crossref]
[5] Jeong S-H, Jang J-H, Lee Y-B. Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors. J Pharm Investig. 2023;53(1):119-152. [Crossref] [6] Bhatta RS, Chandasana H, Chhonker YS, Rathi C, Kumar D, Mitra K, Shukla PK. Mucoadhesive nanoparticles for prolonged ocular delivery of natamycin: In vitro and pharmacokinetics studies. Int J Pharm. 2012; 432(1-2):105-112. [Crossref]

Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Conference Paper

Authors

Işık Çelikkol This is me
Türkiye

Özge Eşim ^* This is me
0000-0002-1053-0369
Türkiye

Canan Hasçiçek
0000-0003-3577-4930
Türkiye

Publication Date

June 28, 2025

Submission Date

February 28, 2023

Acceptance Date

March 14, 2023

Published in Issue

Year 2023 Volume: 27 Number: Current Research Topıcs In Pharmacy: Drug Delivery

IZ

https://izlik.org/JA85WL94CW

Cite

RIS / Bibtex

APA

Çelikkol, I., Eşim, Ö., & Hasçiçek, C. (2025). NOSE-TO-BRAIN DRUG DELIVERY OF NANOFORMULATIONS: PREPARATION AND IN VITRO EVALUATION. Journal of Research in Pharmacy, 27(Current Research Topıcs In Pharmacy: Drug Delivery), 13-16. https://izlik.org/JA85WL94CW

AMA

1.Çelikkol I, Eşim Ö, Hasçiçek C. NOSE-TO-BRAIN DRUG DELIVERY OF NANOFORMULATIONS: PREPARATION AND IN VITRO EVALUATION. J. Res. Pharm. 2025;27(Current Research Topıcs In Pharmacy: Drug Delivery):13-16. https://izlik.org/JA85WL94CW

Chicago

Çelikkol, Işık, Özge Eşim, and Canan Hasçiçek. 2025. “NOSE-TO-BRAIN DRUG DELIVERY OF NANOFORMULATIONS: PREPARATION AND IN VITRO EVALUATION”. Journal of Research in Pharmacy 27 (Current Research Topıcs In Pharmacy: Drug Delivery): 13-16. https://izlik.org/JA85WL94CW.

EndNote

Çelikkol I, Eşim Ö, Hasçiçek C (July 1, 2025) NOSE-TO-BRAIN DRUG DELIVERY OF NANOFORMULATIONS: PREPARATION AND IN VITRO EVALUATION. Journal of Research in Pharmacy 27 Current Research Topıcs In Pharmacy: Drug Delivery 13–16.

IEEE

[1]I. Çelikkol, Ö. Eşim, and C. Hasçiçek, “NOSE-TO-BRAIN DRUG DELIVERY OF NANOFORMULATIONS: PREPARATION AND IN VITRO EVALUATION”, J. Res. Pharm., vol. 27, no. Current Research Topıcs In Pharmacy: Drug Delivery, pp. 13–16, July 2025, [Online]. Available: https://izlik.org/JA85WL94CW

ISNAD

Çelikkol, Işık - Eşim, Özge - Hasçiçek, Canan. “NOSE-TO-BRAIN DRUG DELIVERY OF NANOFORMULATIONS: PREPARATION AND IN VITRO EVALUATION”. Journal of Research in Pharmacy 27/Current Research Topıcs In Pharmacy: Drug Delivery (July 1, 2025): 13-16. https://izlik.org/JA85WL94CW.

JAMA

1.Çelikkol I, Eşim Ö, Hasçiçek C. NOSE-TO-BRAIN DRUG DELIVERY OF NANOFORMULATIONS: PREPARATION AND IN VITRO EVALUATION. J. Res. Pharm. 2025;27:13–16.

MLA

Çelikkol, Işık, et al. “NOSE-TO-BRAIN DRUG DELIVERY OF NANOFORMULATIONS: PREPARATION AND IN VITRO EVALUATION”. Journal of Research in Pharmacy, vol. 27, no. Current Research Topıcs In Pharmacy: Drug Delivery, July 2025, pp. 13-16, https://izlik.org/JA85WL94CW.

Vancouver

1.Işık Çelikkol, Özge Eşim, Canan Hasçiçek. NOSE-TO-BRAIN DRUG DELIVERY OF NANOFORMULATIONS: PREPARATION AND IN VITRO EVALUATION. J. Res. Pharm. [Internet]. 2025 Jul. 1;27(Current Research Topıcs In Pharmacy: Drug Delivery):13-6. Available from: https://izlik.org/JA85WL94CW