A comparative study of biochemical, antimicrobial effects and phytochemical composition analysis of Glycyrrhiza glabra L. varieties root extracts

Gizem Gülmez; Ali Şen; Hüseyin Servi; Timur Hakan Barak; Fethullah Tekin; Mahdi Marzi; Azize Şener

doi:10.12991/jrespharm.1797864

A comparative study of biochemical, antimicrobial effects and phytochemical composition analysis of Glycyrrhiza glabra L. varieties root extracts

Abstract

Plants are the significant global interest as alternative treatment sources with their biologically active compounds. This study compares the chemical composition and the antioxidant, antidiabetic, and antimicrobial properties of ethanol extracts of G. glabra L. two different varieties from different regions. The phytochemical compositions was determined using GC-MS. Additionaly, total phenolic (TPC), flavonoid (TFC) and triterpene (TTC) contents were determined. Glycyrrhizic acid contents were analysed by HPLC. G. glabra var. glandulifera (GF1) showed the highest antioxidant activity. All extracts had strong antidiabetic effects, besides GF1 showing the highest effect. The MIC values was determined against 8 bacterial and 1 yeast strain and values ranged from 2.500 to 0.500; 2.500 to 0.714; 2.500 to 0.714 for G. glabra var. glabra (GB), GF1, G. glabra var. glandulifera (GF2) respectively. Phytochemical studies have shown that TPC was 100.60±5.06, 127.90±0.30, 69.01±0.30 mg GAE /g extract; TFC was 80.07±0.15, 25.35±0.0, 16.58±0.31 mg KE/g and TTC was 217.30±6.05,172.40±2.17, 126.30±4.50 mg OE/g extract for GB, GF1, GF2, respectively. GF1 in particular has the highest glycyrrhizic acid content. This study will contribute to the creation of new treatment strategies and potential therapeutic agents in addition to the use of G. glabra L. in traditional treatments. Our study is also a preliminary study for future studies.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy, Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Gizem Gülmez ^*
0000-0002-2036-7892
Türkiye

Ali Şen
0000-0002-2144-5741
Türkiye

Hüseyin Servi
0000-0002-4683-855X
Türkiye

Timur Hakan Barak
0000-0002-7434-3175
Türkiye

Fethullah Tekin
0000-0003-3710-1705
Türkiye

Mahdi Marzi
0000-0002-8518-0818
Türkiye

Azize Şener
0000-0002-3125-8720
Türkiye

Publication Date

November 2, 2025

Submission Date

April 30, 2025

Acceptance Date

May 2, 2025

Published in Issue

Year 2025 Volume: 29 Number: 6

DOI

https://doi.org/10.12991/jrespharm.1797864

IZ

https://izlik.org/JA93SK88WE

Cite

RIS / Bibtex

APA

Gülmez, G., Şen, A., Servi, H., Barak, T. H., Tekin, F., Marzi, M., & Şener, A. (2025). A comparative study of biochemical, antimicrobial effects and phytochemical composition analysis of Glycyrrhiza glabra L. varieties root extracts. Journal of Research in Pharmacy, 29(6), 2361-2372. https://doi.org/10.12991/jrespharm.1797864

AMA

1.Gülmez G, Şen A, Servi H, et al. A comparative study of biochemical, antimicrobial effects and phytochemical composition analysis of Glycyrrhiza glabra L. varieties root extracts. J. Res. Pharm. 2025;29(6):2361-2372. doi:10.12991/jrespharm.1797864

Chicago

Gülmez, Gizem, Ali Şen, Hüseyin Servi, et al. 2025. “A Comparative Study of Biochemical, Antimicrobial Effects and Phytochemical Composition Analysis of Glycyrrhiza Glabra L. Varieties Root Extracts”. Journal of Research in Pharmacy 29 (6): 2361-72. https://doi.org/10.12991/jrespharm.1797864.

EndNote

Gülmez G, Şen A, Servi H, Barak TH, Tekin F, Marzi M, Şener A (November 1, 2025) A comparative study of biochemical, antimicrobial effects and phytochemical composition analysis of Glycyrrhiza glabra L. varieties root extracts. Journal of Research in Pharmacy 29 6 2361–2372.

IEEE

[1]G. Gülmez et al., “A comparative study of biochemical, antimicrobial effects and phytochemical composition analysis of Glycyrrhiza glabra L. varieties root extracts”, J. Res. Pharm., vol. 29, no. 6, pp. 2361–2372, Nov. 2025, doi: 10.12991/jrespharm.1797864.

ISNAD

Gülmez, Gizem - Şen, Ali - Servi, Hüseyin - Barak, Timur Hakan - Tekin, Fethullah - Marzi, Mahdi - Şener, Azize. “A Comparative Study of Biochemical, Antimicrobial Effects and Phytochemical Composition Analysis of Glycyrrhiza Glabra L. Varieties Root Extracts”. Journal of Research in Pharmacy 29/6 (November 1, 2025): 2361-2372. https://doi.org/10.12991/jrespharm.1797864.

JAMA

1.Gülmez G, Şen A, Servi H, Barak TH, Tekin F, Marzi M, Şener A. A comparative study of biochemical, antimicrobial effects and phytochemical composition analysis of Glycyrrhiza glabra L. varieties root extracts. J. Res. Pharm. 2025;29:2361–2372.

MLA

Gülmez, Gizem, et al. “A Comparative Study of Biochemical, Antimicrobial Effects and Phytochemical Composition Analysis of Glycyrrhiza Glabra L. Varieties Root Extracts”. Journal of Research in Pharmacy, vol. 29, no. 6, Nov. 2025, pp. 2361-72, doi:10.12991/jrespharm.1797864.

Vancouver

1.Gizem Gülmez, Ali Şen, Hüseyin Servi, Timur Hakan Barak, Fethullah Tekin, Mahdi Marzi, Azize Şener. A comparative study of biochemical, antimicrobial effects and phytochemical composition analysis of Glycyrrhiza glabra L. varieties root extracts. J. Res. Pharm. 2025 Nov. 1;29(6):2361-72. doi:10.12991/jrespharm.1797864

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