Anti-Endocrine Properties of Ganoderma Lucidum on Streptozotocin-Induced Diabetic Rats

Year 2026, Volume: 30 Issue: 1, 320 - 329, 11.01.2026

Macdonald Idu , Coker Oluwaseun Oritsema Benjamin Ogunma Gabriel

https://doi.org/10.12991/jrespharm.1845180

Abstract

Ganoderma lucidum has several therapeutic effects, which include; antidiabetic, antihypertensive, antilipidemic, antioxidant, and many more. This study evaluates the anti-endocrine investigation of G. lucidum in streptozotocin-induced diabetic rats. Antidiabetic properties of a modified streptozotocin-induced hyperglycemic model were used. Wistar rats were divided into six groups (n=5). All groups except normal control were induced with streptozotocin (50 mg/kg). Graded doses (30, 50, and 100 mg/kg) of G. lucidum methanol extract and 10 mg/kg glibenclamide were administered for 14 days. Blood glucose was monitored on Days 1, 7, and 14. Blood and tissue samples were analyzed for biochemical and histopathological screening. The anti-endocrine property showed a significant increase in the body weight and HDL (14.99) with an decrease in blood glucose level (day 0= 199.5, 7= 79.00 and 14= 56.00), total cholesterol (73.76), triglycerides (199.30) and LDL level (47.30), ALT (24.48), AST (43.86), ALP (13.36), GGC (0.53), TP (12.72), urea (28.78), creatinine (0.25), sodium (94.69) when compared with the control. A significant decrease in the pancreas and live weight with normal architectural functioning of the organs treated groups when compared with the control. These findings elicited G. lucidum elicited antidiabetic properties.

Keywords

Antidiabetic , Garnoderma lucidum , Stroptozotocin

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