Anti-Endocrine Properties of Ganoderma Lucidum on Streptozotocin-Induced Diabetic Rats

Macdonald Idu; Coker Oluwaseun Oritsema; Benjamin Ogunma Gabriel

doi:10.12991/jrespharm.1845180

Anti-Endocrine Properties of Ganoderma Lucidum on Streptozotocin-Induced Diabetic Rats

Abstract

Ganoderma lucidum has several therapeutic effects, which include; antidiabetic, antihypertensive, antilipidemic, antioxidant, and many more. This study evaluates the anti-endocrine investigation of G. lucidum in streptozotocin-induced diabetic rats. Antidiabetic properties of a modified streptozotocin-induced hyperglycemic model were used. Wistar rats were divided into six groups (n=5). All groups except normal control were induced with streptozotocin (50 mg/kg). Graded doses (30, 50, and 100 mg/kg) of G. lucidum methanol extract and 10 mg/kg glibenclamide were administered for 14 days. Blood glucose was monitored on Days 1, 7, and 14. Blood and tissue samples were analyzed for biochemical and histopathological screening. The anti-endocrine property showed a significant increase in the body weight and HDL (14.99) with an decrease in blood glucose level (day 0= 199.5, 7= 79.00 and 14= 56.00), total cholesterol (73.76), triglycerides (199.30) and LDL level (47.30), ALT (24.48), AST (43.86), ALP (13.36), GGC (0.53), TP (12.72), urea (28.78), creatinine (0.25), sodium (94.69) when compared with the control. A significant decrease in the pancreas and live weight with normal architectural functioning of the organs treated groups when compared with the control. These findings elicited G. lucidum elicited antidiabetic properties.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biotechnology

Journal Section

Research Article

Authors

Macdonald Idu
0000-0002-5082-1988
Benin

Coker Oluwaseun Oritsema This is me
0009-0005-3848-5642
Benin

Benjamin Ogunma Gabriel ^* This is me
0000-0002-2513-385X
Benin

Publication Date

January 11, 2026

Submission Date

September 30, 2022

Acceptance Date

September 16, 2024

Published in Issue

Year 2026 Volume: 30 Number: 1

DOI

https://doi.org/10.12991/jrespharm.1845180

IZ

https://izlik.org/JA85RD83NU

Cite

RIS / Bibtex

APA

Idu, M., Oritsema, C. O., & Gabriel, B. O. (2026). Anti-Endocrine Properties of Ganoderma Lucidum on Streptozotocin-Induced Diabetic Rats. Journal of Research in Pharmacy, 30(1), 320-329. https://doi.org/10.12991/jrespharm.1845180

AMA

1.Idu M, Oritsema CO, Gabriel BO. Anti-Endocrine Properties of Ganoderma Lucidum on Streptozotocin-Induced Diabetic Rats. J. Res. Pharm. 2026;30(1):320-329. doi:10.12991/jrespharm.1845180

Chicago

Idu, Macdonald, Coker Oluwaseun Oritsema, and Benjamin Ogunma Gabriel. 2026. “Anti-Endocrine Properties of Ganoderma Lucidum on Streptozotocin-Induced Diabetic Rats”. Journal of Research in Pharmacy 30 (1): 320-29. https://doi.org/10.12991/jrespharm.1845180.

EndNote

Idu M, Oritsema CO, Gabriel BO (January 1, 2026) Anti-Endocrine Properties of Ganoderma Lucidum on Streptozotocin-Induced Diabetic Rats. Journal of Research in Pharmacy 30 1 320–329.

IEEE

[1]M. Idu, C. O. Oritsema, and B. O. Gabriel, “Anti-Endocrine Properties of Ganoderma Lucidum on Streptozotocin-Induced Diabetic Rats”, J. Res. Pharm., vol. 30, no. 1, pp. 320–329, Jan. 2026, doi: 10.12991/jrespharm.1845180.

ISNAD

Idu, Macdonald - Oritsema, Coker Oluwaseun - Gabriel, Benjamin Ogunma. “Anti-Endocrine Properties of Ganoderma Lucidum on Streptozotocin-Induced Diabetic Rats”. Journal of Research in Pharmacy 30/1 (January 1, 2026): 320-329. https://doi.org/10.12991/jrespharm.1845180.

JAMA

1.Idu M, Oritsema CO, Gabriel BO. Anti-Endocrine Properties of Ganoderma Lucidum on Streptozotocin-Induced Diabetic Rats. J. Res. Pharm. 2026;30:320–329.

MLA

Idu, Macdonald, et al. “Anti-Endocrine Properties of Ganoderma Lucidum on Streptozotocin-Induced Diabetic Rats”. Journal of Research in Pharmacy, vol. 30, no. 1, Jan. 2026, pp. 320-9, doi:10.12991/jrespharm.1845180.

Vancouver

1.Macdonald Idu, Coker Oluwaseun Oritsema, Benjamin Ogunma Gabriel. Anti-Endocrine Properties of Ganoderma Lucidum on Streptozotocin-Induced Diabetic Rats. J. Res. Pharm. 2026 Jan. 1;30(1):320-9. doi:10.12991/jrespharm.1845180