Wound care membranes containing storax oil (Liquidambar orientalis miller) and absorbent materials fabricated by blend electrospinning

Yasemin Yağan Uzuner; Neval Sevinç Özdemir

doi:10.12991/jrespharm.1878515

Wound care membranes containing storax oil (Liquidambar orientalis miller) and absorbent materials fabricated by blend electrospinning

Abstract

Oriental sweetgum balsam or Storax oil (Styrax liquidus) naturally exudes from wounds made on the tree trunk of Liquidambar orientalis. It is a natural material with antibacterial, antimicrobial, antitumor, and antioxidant properties. In traditional folk medicine, it has long been used in the treatment of gastric and skin diseases, therefore it is a good candidate for wound care applications. Electrospinning offers a platform to combine storax oil with poly(ε-caprolactone) (PCL) fibers together with hydrophilic absorbent polysaccharides. In this study, a single-step fabrication of flexible, lightweight, fibrous membranes was achieved which combined compatible formulations of PCL, storax oil, and either sodium alginate or chitosan as absorbent additives. PCL–Styrax–Chitosan and PCL–Styrax–Alginate membranes were compared to assess their morphology, surface wettability, and mechanical properties, with a focus on achieving homogeneous oil distribution and suitable exudate management through the absorbents. Scanning electron microscopy images revealed relatively uniform fibrous structures for PCL–Styrax and PCL–Styrax–Chitosan combinations, whereas alginate led to partially fused fibers. Hydrophilicity increased significantly with the addition of chitosan or alginate. Mechanical testing showed that chitosan improved flexibility and yielded an elastic modulus very close to skin elasticity, while alginate sharply increased the stiffness. In conclusion, PCL–Styrax–Chitosan membranes may prove to be a promising functional wound dressing opportunity that integrates a traditionally used natural balsam with favorable functions. Furthermore, the fiber morphology, wettability, mechanical strength and flexibility of the membranes are also suitable for this purpose. Future work should address storax oil release kinetics and membrane handling features as wound dressing, prior to in vitro and in vivo wound-healing evaluations.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Yasemin Yağan Uzuner ^*
0000-0001-6586-4158
Türkiye

Neval Sevinç Özdemir
Türkiye

Publication Date

March 15, 2026

Submission Date

January 31, 2026

Acceptance Date

March 13, 2026

Published in Issue

Year 2026 Volume: 30 Number: 2

DOI

https://doi.org/10.12991/jrespharm.1878515

IZ

https://izlik.org/JA68AR66NP

Cite

RIS / Bibtex

APA

Yağan Uzuner, Y., & Sevinç Özdemir, N. (2026). Wound care membranes containing storax oil (Liquidambar orientalis miller) and absorbent materials fabricated by blend electrospinning. Journal of Research in Pharmacy, 30(2), 671-680. https://doi.org/10.12991/jrespharm.1878515

AMA

1.Yağan Uzuner Y, Sevinç Özdemir N. Wound care membranes containing storax oil (Liquidambar orientalis miller) and absorbent materials fabricated by blend electrospinning. J. Res. Pharm. 2026;30(2):671-680. doi:10.12991/jrespharm.1878515

Chicago

Yağan Uzuner, Yasemin, and Neval Sevinç Özdemir. 2026. “Wound Care Membranes Containing Storax Oil (Liquidambar Orientalis Miller) and Absorbent Materials Fabricated by Blend Electrospinning”. Journal of Research in Pharmacy 30 (2): 671-80. https://doi.org/10.12991/jrespharm.1878515.

EndNote

Yağan Uzuner Y, Sevinç Özdemir N (March 1, 2026) Wound care membranes containing storax oil (Liquidambar orientalis miller) and absorbent materials fabricated by blend electrospinning. Journal of Research in Pharmacy 30 2 671–680.

IEEE

[1]Y. Yağan Uzuner and N. Sevinç Özdemir, “Wound care membranes containing storax oil (Liquidambar orientalis miller) and absorbent materials fabricated by blend electrospinning”, J. Res. Pharm., vol. 30, no. 2, pp. 671–680, Mar. 2026, doi: 10.12991/jrespharm.1878515.

ISNAD

Yağan Uzuner, Yasemin - Sevinç Özdemir, Neval. “Wound Care Membranes Containing Storax Oil (Liquidambar Orientalis Miller) and Absorbent Materials Fabricated by Blend Electrospinning”. Journal of Research in Pharmacy 30/2 (March 1, 2026): 671-680. https://doi.org/10.12991/jrespharm.1878515.

JAMA

1.Yağan Uzuner Y, Sevinç Özdemir N. Wound care membranes containing storax oil (Liquidambar orientalis miller) and absorbent materials fabricated by blend electrospinning. J. Res. Pharm. 2026;30:671–680.

MLA

Yağan Uzuner, Yasemin, and Neval Sevinç Özdemir. “Wound Care Membranes Containing Storax Oil (Liquidambar Orientalis Miller) and Absorbent Materials Fabricated by Blend Electrospinning”. Journal of Research in Pharmacy, vol. 30, no. 2, Mar. 2026, pp. 671-80, doi:10.12991/jrespharm.1878515.

Vancouver

1.Yasemin Yağan Uzuner, Neval Sevinç Özdemir. Wound care membranes containing storax oil (Liquidambar orientalis miller) and absorbent materials fabricated by blend electrospinning. J. Res. Pharm. 2026 Mar. 1;30(2):671-80. doi:10.12991/jrespharm.1878515