Sonchus arvensis leaves water fraction alleviates inflammation symptoms in a rat model of acute gouty arthritis

Nita Parisa; Ernawati Sinaga; Muhammad Totong Kamaluddin; Irsan Saleh; Radiyati Umi Partan; Irfannuddin Irfannuddin; Sonlimar Mangunsong

Sonchus arvensis leaves water fraction alleviates inflammation symptoms in a rat model of acute gouty arthritis

Abstract

Gouty arthritis is inflammation of the joints that occurs in conditions of chronic hyperuricemia. When an acute attack of gout arthritis begins, oral colchicine is often given as the main treatment. However, colchicine can cause various side effects. Tempuyung (Sonchus arvensis) is a plant that is often found and easily cultivated in Indonesia, which has strong anti-inflammatory potential due to the presence of flavonoid compounds. This research aimed to investigate the anti-inflammatory activity of S. Arvensis leaves water fraction (SALWF) and detect flavonoids contained in it. An animal model of acute gouty arthritis was established using monosodium urate crystals injection. SALWF at 10 mg/kg BW was found to be effective in reducing the inflammation of the knee joint (p < 0.0001) and resulted in improvement in the H & E histological results. SALWF at 20 (p < 0.0001) and 40 mg/kg BW (p < 0.0005) also significantly alleviated swelling. Nevertheless, no histological improvements were observed at both doses. Eight flavonoids were successfully identified from LC-MS/MS, showing a significant proportion of baicalin and kaempferol 3-O-β-Dglucuronopyranoside. This research further establishes the use of SALWF for the management of acute gouty arthritis.

Keywords

References

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Details

Primary Language

English

Subjects

Basic Pharmacology

Journal Section

Research Article

Authors

Nita Parisa
0000-0003-1459-7015
Indonesia

Ernawati Sinaga ^*
0000-0002-4739-6909
Indonesia

Muhammad Totong Kamaluddin This is me
0000-0002-8670-9867
Indonesia

Irsan Saleh
0000-0003-4788-8409
Indonesia

Radiyati Umi Partan This is me
0000-0001-5853-2112
Indonesia

Irfannuddin Irfannuddin This is me
0000-0002-2217-367X
Indonesia

Sonlimar Mangunsong This is me
0000-0002-0523-7870
Indonesia

Publication Date

August 3, 2026

Submission Date

July 1, 2024

Acceptance Date

September 22, 2024

Published in Issue

Year 2026 Volume: 30 Number: 4

IZ

https://izlik.org/JA89MC44YC

Cite

RIS / Bibtex

APA

Parisa, N., Sinaga, E., Kamaluddin, M. T., Saleh, I., Partan, R. U., Irfannuddin, I., & Mangunsong, S. (2026). Sonchus arvensis leaves water fraction alleviates inflammation symptoms in a rat model of acute gouty arthritis. Journal of Research in Pharmacy, 30(4), 1045-1054. https://izlik.org/JA89MC44YC

AMA

1.Parisa N, Sinaga E, Kamaluddin MT, et al. Sonchus arvensis leaves water fraction alleviates inflammation symptoms in a rat model of acute gouty arthritis. J. Res. Pharm. 2026;30(4):1045-1054. https://izlik.org/JA89MC44YC

Chicago

Parisa, Nita, Ernawati Sinaga, Muhammad Totong Kamaluddin, et al. 2026. “Sonchus Arvensis Leaves Water Fraction Alleviates Inflammation Symptoms in a Rat Model of Acute Gouty Arthritis”. Journal of Research in Pharmacy 30 (4): 1045-54. https://izlik.org/JA89MC44YC.

EndNote

Parisa N, Sinaga E, Kamaluddin MT, Saleh I, Partan RU, Irfannuddin I, Mangunsong S (August 1, 2026) Sonchus arvensis leaves water fraction alleviates inflammation symptoms in a rat model of acute gouty arthritis. Journal of Research in Pharmacy 30 4 1045–1054.

IEEE

[1]N. Parisa et al., “Sonchus arvensis leaves water fraction alleviates inflammation symptoms in a rat model of acute gouty arthritis”, J. Res. Pharm., vol. 30, no. 4, pp. 1045–1054, Aug. 2026, [Online]. Available: https://izlik.org/JA89MC44YC

ISNAD

Parisa, Nita - Sinaga, Ernawati - Kamaluddin, Muhammad Totong - Saleh, Irsan - Partan, Radiyati Umi - Irfannuddin, Irfannuddin - Mangunsong, Sonlimar. “Sonchus Arvensis Leaves Water Fraction Alleviates Inflammation Symptoms in a Rat Model of Acute Gouty Arthritis”. Journal of Research in Pharmacy 30/4 (August 1, 2026): 1045-1054. https://izlik.org/JA89MC44YC.

JAMA

1.Parisa N, Sinaga E, Kamaluddin MT, Saleh I, Partan RU, Irfannuddin I, Mangunsong S. Sonchus arvensis leaves water fraction alleviates inflammation symptoms in a rat model of acute gouty arthritis. J. Res. Pharm. 2026;30:1045–1054.

MLA

Parisa, Nita, et al. “Sonchus Arvensis Leaves Water Fraction Alleviates Inflammation Symptoms in a Rat Model of Acute Gouty Arthritis”. Journal of Research in Pharmacy, vol. 30, no. 4, Aug. 2026, pp. 1045-54, https://izlik.org/JA89MC44YC.

Vancouver

1.Nita Parisa, Ernawati Sinaga, Muhammad Totong Kamaluddin, Irsan Saleh, Radiyati Umi Partan, Irfannuddin Irfannuddin, Sonlimar Mangunsong. Sonchus arvensis leaves water fraction alleviates inflammation symptoms in a rat model of acute gouty arthritis. J. Res. Pharm. [Internet]. 2026 Aug. 1;30(4):1045-54. Available from: https://izlik.org/JA89MC44YC