Phytosome based cosmeceuticals for enhancing percutaneous absorption and delivery

Year 2025, Volume: 29 Issue: 1, 242 - 271

Jyotsana Dwivedi , Pranay Wal Shubhi Kaushal , Arpan Kumar Tripathi , Priyanka Gupta Surada Prakash Rao

Abstract

The therapeutic efficacy of various phytoconstituents is improved by the use of phytosome, innovative drug delivery methods based on phytochemicals, by enhancing their absorption, bioavailability, and therapeutic availability. This exceedingly complex type of herbal formulation contains the active phytoconstituent of the herbal extract and is joined by a phospholipid molecule. They also operate as vesicular systems for a wide range of fascinating and important phytoactives. The phytosome method produces startlingly tiny spheres or cells, which is advantageous in keeping active phytochemical contents from being destroyed by the stomach environment. Phytosome also produce pharmacokinetic and pharmacodynamic effects that are more potent than those of conventional herbal extracts. Phytosome demonstrated increased pharmacokinetics and pharmacodynamic response when compared to conventional botanical extracts. Through the use of phytosome technology, the bioavailability of several of the most widely used herbal extracts, such as milk thistle, Ginkgo biloba, grape seed, green tea, hawthorn, ginseng, etc., has been improved. These drug-phospholipid complexes can be produced as a liquid solution, suspension, emulsion, syrup, lotion, gel, cream, tablet, capsule, powder, or granule. The purpose of this review is to emphasize the application of how the phytosome technology has helped to improve the bioavailability and absorbance of the cosmeceuticals.

Keywords

Phytosome, Phytoconstituents, Cosmeceuticals, Herbal extracts, Bioavailability

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