Interplay of Extended Clearance and Salivary Excretion Classification Systems

Year 2025, Volume: 29 Issue: 4, 1374 - 1378, 05.07.2025

Nasir Idkaidek , Esraa Idkaidek

https://doi.org/10.12991/jrespharm.1639160

Abstract

The aim of this commentary is to investigate the interplay of Extended Clearance Classification System (ECCS) and Salivary Excretion Classification System (SECS). ECCS utilized the involvement of transporters to classify drugs based on permeability, ionization and molecular weight for the purpose of predicting rate determining clearance. On the other hand, SECS classified drugs based on permeability and protein binding for the purpose of predicting salivary excretion of drugs.
Conclusion: The proposed Salivary Excretion Classification System (SECS) can be used as a guide for drug salivary excretion based on permeability and protein binding, but not transporters involved.

Keywords

EECS , SECS , BCS , ADMIT predictor , transporters

Ethical Statement

NA

Supporting Institution

This research was supported by Petra University financial grant # 2-4-2023

Thanks

ADMIT predictor is used under academic license granted to Petra University from Simulation Plus, USA.

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