Evaluation the antioxidant effect of chromium picolinate in doxorubicin induced cardiotoxicity in a rat model

Year 2025, Volume: 29 Issue: 4, 1582 - 1589, 05.07.2025

Asmaa Muhammad Khalifa Ali Faris Hassan

https://doi.org/10.12991/jrespharm.1734616

Abstract

Doxorubicin (DOX) is a potent antineoplastic drug used to treat many types of human tumor. The long-term
adverse effect is cardiomyopathy. Chromium is an essential trace element mostly used to regulate glucose levels and
enhance the response to insulin, especially in diabetes. Current study aimed to evaluate the cardioprotective effect of
chromium picolinate against doxorubicin-induced cardiotoxicity in 28 male rats divided into four groups. Group I (Control
group): received distilled water orally for 8 days. Group II (Doxorubicin group): received distilled water orally for 7 days,
followed by a single doxorubicin dose (25 mg/kg) intraperitoneally. Group III (Chromium 2 mg): received chromium
picolinate at a dose (2 mg /kg) orally for 7 days, followed by a single doxorubicin dose (25 mg/kg) intraperitoneally.
Group IV (Chromium 4 mg): received chromium picolinate at a dose (4 mg /kg) orally for 7 days, followed by a single
doxorubicin dose (25 mg/kg) intraperitoneally. Levels of lactate dehydrogenase (LDH) and serum troponin were assessed
in the sera of all groups by ELISA technique while the cardiac homogenate used to assess malondialdehyde (MDA) by
ELISA technique and superoxide dismutase (SOD) by RT-qPCR method and the results indicated that the co-
administration of chromium picolinate at dose (2mg/kg) and (4mg/kg) caused a significant decrease in cardiac LDH and
MDA and significant elevation in SOD level in groups III and IV compared to group II This current research indicated that
Chromium picolinate have a potential role in reducing cardiac injury and oxidative stress in patients treated with
doxorubicin.

Keywords

Cardiotoxicity , chromium picolinate , lactate dehydrogenase , superoxide dismutase , serum troponin

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