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Year 2025, Volume: 29 Issue: 4, 1726 - 1731, 05.07.2025

Pınar Dede , Seren Ede-pazarbaşi Doğancan Dörücü , Göksel Şener , Tuğba Tunalı-akbay

https://doi.org/10.12991/jrespharm.1734682

Abstract

References

  • [1] Matuszczak E, Komarowska MD, Debek W, Hermanowicz A. The impact of bisphenol A on fertility, reproductive system, and development: a review of the literature. Int J Endocrinol. 2019 ;2019:4068717. https://doi.org/10.1155/2019/4068717
  • [2] Schecter A, Malik N, Haffner D, Smith S, Harris TR, Paepke O, Birnbaum L. Bisphenol A (BPA) in US food. Environ Sci Technol. 2010;44(24):9425-9430. https://doi.org/10.1021/es102785d
  • [3] Cimmino I, Fiory F, Perruolo G, Miele C, Beguinot F, Formisano P, Oriente F. Potential mechanisms of bisphenol A (BPA) contributing to human disease. Int J Mol Sci. 2020;21(16):5761. https://doi.org/110.3390/ijms21165761
  • [4] Rochester JR. Bisphenol A and human health: A review of the literature. Reprod Toxicol. 2013;42:132-155. https://doi.org/110.1016/j.reprotox.2013.08.008
  • [5] Gassman NR. Induction of oxidative stress by bisphenol A and its pleiotropic effects. Environ Mol Mutagen. 2017;58(2):60-71. https://doi.org/110.1002/em.22072
  • [6] Yang YJ, Hong YC, Oh SY, Park MS, Kim H, Leem JH, Ha EH. Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women. Environ Res. 2009;109(6):797-801. https://doi.org/10.1016/j.envres.2009.04.014
  • [7] Meli R, Monnolo A, Annunziata C, Pirozzi C, Ferrante MC. Oxidative stress and BPA toxicity: an antioxidant approach for male and female reproductive dysfunction. Antioxidants. 2020;9(5):405. https://doi.org/10.3390/antiox9050405
  • [8] Kazemi S, Mousavi SN, Aghapour F, Rezaee B, Sadeghi F, Moghadamnia AA. Induction effect of bisphenol A on gene expression involving hepatic oxidative stress in rat. Oxid Med Cell Longev. 2016;2016:6298515. https://doi.org/10.1155/2016/6298515
  • [9] Avci B, Bahadir A, Tuncel OK, Bilgici B. Influence of α-tocopherol and α-lipoic acid on bisphenol-A-induced oxidative damage in liver and ovarian tissue of rats. Toxicol Ind Health. 2016;32(8):1381-1390. https://doi.org/10.1177/0748233714563433
  • [10] Watkins DJ, Peterson KE, Ferguson KK, Mercado-García A, Tamayo y Ortiz M, Cantoral A, Meeker JD, Téllez-Rojo MM. Relating phthalate and BPA exposure to metabolism in peripubescence: the role of exposure timing, sex, and puberty. J Clin Endocrinol. 2016;101(1):79-88. https://doi.org/10.1210/jc.2015-2706
  • [11] Doron S, Snydman DR, Gorbach SL. Lactobacillus GG: bacteriology and clinical applications. Gastroenterol Clin. 2005;34(3):483-498. https://doi.org/10.1016/j.gtc.2005.05.011
  • [12] Segers ME, Lebeer S. Towards a better understanding of Lactobacillus rhamnosus GG-host interactions. Microb Cell Fact. 2014;13(1):1-16. https://doi.org/10.1186/1475-2859-13-S1-S7
  • [13] Liu C-F, Pan T-M. In vitro effects of lactic acid bacteria on cancer cell viability and antioxidant activity. J Food Drug Anal. 2010;18(2):8. https://doi.org/10.38212/2224-6614.2287
  • [14] Zamberlin S, Spehar ID, Kelava N, Samarzija D. Probiotic bacterium Lactobacillus rhamnosus: Beneficial and a diverse effects on human health. Milchwissenschaft. 2012;67(1):30-33.
  • [15] Martarelli D, Verdenelli MC, Scuri S, Cocchioni M, Silvi S, Cecchini C, et al. Effect of a probiotic intake on oxidant and antioxidant parameters in plasma of athletes during intense exercise training. Curr Microbiol. 2011;62:1689-1696. https://doi.org/10.1007/s00284-011-9915-3
  • [16] Pawar SH. Lactobacillus rhamnosus ARJD as a functional food with potential antioxidant and antibacterial abilities. Acta Sci Pharm Sci. 2019;3:63-70. https://doi.org/10.31080/ASPS.2019.03.0341
  • [17] Kleniewska P, Hoffmann A, Pniewska E, Pawliczak R. The influence of probiotic Lactobacillus casei in combination with prebiotic inulin on the antioxidant capacity of human plasma. Oxid Med Cell Longev. 2016;2016:1340903. https://doi.org/10.1155/2016/1340903
  • [18] Çibuk S, Yılmaz H, Mert H, Mis L, Yörük M, Mert N. Effect of Bisphenol-A on oxidative status and certain ınflammatory markers in rats: Experimental study. Türkiye Klin Vet Bil (online). 2023;14(2). https://doi.org/10.5336/vetsci.2023-98134
  • [19] Kabuto H, Hasuike S, Minagawa N, Shishibori T. Effects of bisphenol A on the metabolisms of active oxygen species in mouse tissues. Environ Res. 2003;93(1):31-35. https://doi.org/10.1016/S0013-9351(03)00062-8
  • [20] Amaretti A, Di Nunzio M, Pompei A, Raimondi S, Rossi M, Bordoni A. Antioxidant properties of potentially probiotic bacteria: In vitro and in vivo activities. Appl Microbiol Biotechnol. 2013;97:809-817. https://doi.org/10.1007/s00253-012-4241-7
  • [21] Sun J, Hu XL, Le GW, Shi YH. Lactobacilli prevent hydroxy radical production and inhibit Escherichia coli and Enterococcus growth in system mimicking colon fermentation. Lett Appl Microbiol. 2010;50(3):264-269. https://doi.org/10.1111/j.1472-765X.2009.02786.x
  • [22] Mahdavinia M, Khorsandi L, Alboghobeish S, Samimi A, Dehghani MA, Zeidooni L. Liver histopathological alteration and dysfunction after bisphenol A administration in male rats and protective effects of naringin. Avicenna J Phytomed. 2021;11(4):394. https://doi.org/10.22038/AJP.2021.17649
  • [23] Gualtieri AF, Iwachow MA, Venara M, Rey RA, Schteingart HF. Bisphenol A effect on glutathione synthesis and recycling in testicular Sertoli cells. J Endocrinol Invest. 2011;34:e102-e109. https://doi.org/10.1007/BF03347468
  • [24] Nasonova E. MD Thesis. Mechanisms involved in the cell death in Pc-12 cells and chicken cerebellar neurons under serum deprivation, bisphenol-A exposure and MEHP toxicity, Institute of Biology, University of Oslo, Oslo, Norway 2010. https://www.duo.uio.no/bitstream/handle/10852/11806/Masterthesis-Eugenia-Nasonova.pdf
  • [25] Moghaddam HS, Samarghandian S, Farkhondeh T. Effect of bisphenol A on blood glucose, lipid profile and oxidative stress indices in adult male mice. Toxicol Mech Methods. 2015;25(7):507-513. https://doi.org/10.3109/15376516.2015.1056395
  • [26] Eweda SM, Abdou HM, Abd Elkader H-TAE, El-Gendy AH. Neurotoxicity and neuroinflammatory effects of bisphenol A in male rats: the neuroprotective role of grape seeds proanthocyanidins. Environ Sci Pollut Res Int. 2022;29(6):9257-9268. https://doi.org/10.1007/s11356-021-16311-1
  • [27] Vandenberg LN, Ehrlich S, Belcher SM, Ben-Jonathan N, Dolinoy DC, Hugo ER, Hunt PA, Newbold RR, Rubin BS, Saili KS, Soto AM, Wang H-S, vom Saal FS . Low dose effects of bisphenol A: An integrated review of in vitro, laboratory animal, and epidemiology studies. Endocrine Disrupt. 2013;1(1):e26490. https://doi.org/10.4161/endo.26490
  • [28] Papizadeh M, Nahrevanian H, Rohani M, Hosseini SN, Shojaosadati SA. Lactobacillus rhamnosus Gorbach-Goldin (GG): A top well-researched probiotic strain. J Med Bacteriol. 2016;5(5-6):46-59. https://www.researchgate.net/publication/313221138
  • [29] Beutler E. Nutritional and metabolic aspects of glutathione. Annu Rev Nutr. 1989;9(1):287-302. https://doi.org/10.1146/annurev.nu.09.070189.001443
  • [30] Yagi K. Lipid peroxides and human diseases. Chem Phys Lipids. 1987;45(2-4):337-351. https://doi.org/10.1016/0009-3084(87)90071-5

Lactobacillus rhamnosus GG alleviates bisphenol-A induced oxidative stress in serum

Year 2025, Volume: 29 Issue: 4, 1726 - 1731, 05.07.2025

Pınar Dede , Seren Ede-pazarbaşi Doğancan Dörücü , Göksel Şener , Tuğba Tunalı-akbay

https://doi.org/10.12991/jrespharm.1734682

Abstract

The objective of this investigation was to identify changes in the serum oxidant-antioxidant balance of rats exposed to bisphenol A (BPA) and to investigate the impact of Lactobacillus rhamnosus GG (LGG) administration on those changes. Twenty-four rats (Wistar Albino, 250-300 grams, male) were divided into control, BPA, and BPA+LGG groups with an equal number of rats. BPA and LGG were applied to the rats in the relevant groups for six weeks, five days each week. Six weeks later, the blood samples were withdrawn and serum samples were prepared. Total oxidant and antioxidant status (TAS), glutathione, and lipid peroxidation determinations were determined in serum samples, and the oxidative stress index was calculated. BPA exposure decreased serum total antioxidant status and increased serum total oxidative status, oxidative stress index, and lipid peroxidation level compared to the control group. LGG administration improved the increased serum oxidative stress caused by BPA. Administration of LGG to BPA-treated rats reversed oxidative stress-induced changes. In conclusion, administration of Lactobacillus rhamnosus GG to rats for 30 consecutive days prevented oxidative stress in serum caused by bisphenol A.

Keywords

Bisphenol A Lactobacillus rhamnosus GG probiotic oxidative stress blood

References

  • [1] Matuszczak E, Komarowska MD, Debek W, Hermanowicz A. The impact of bisphenol A on fertility, reproductive system, and development: a review of the literature. Int J Endocrinol. 2019 ;2019:4068717. https://doi.org/10.1155/2019/4068717
  • [2] Schecter A, Malik N, Haffner D, Smith S, Harris TR, Paepke O, Birnbaum L. Bisphenol A (BPA) in US food. Environ Sci Technol. 2010;44(24):9425-9430. https://doi.org/10.1021/es102785d
  • [3] Cimmino I, Fiory F, Perruolo G, Miele C, Beguinot F, Formisano P, Oriente F. Potential mechanisms of bisphenol A (BPA) contributing to human disease. Int J Mol Sci. 2020;21(16):5761. https://doi.org/110.3390/ijms21165761
  • [4] Rochester JR. Bisphenol A and human health: A review of the literature. Reprod Toxicol. 2013;42:132-155. https://doi.org/110.1016/j.reprotox.2013.08.008
  • [5] Gassman NR. Induction of oxidative stress by bisphenol A and its pleiotropic effects. Environ Mol Mutagen. 2017;58(2):60-71. https://doi.org/110.1002/em.22072
  • [6] Yang YJ, Hong YC, Oh SY, Park MS, Kim H, Leem JH, Ha EH. Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women. Environ Res. 2009;109(6):797-801. https://doi.org/10.1016/j.envres.2009.04.014
  • [7] Meli R, Monnolo A, Annunziata C, Pirozzi C, Ferrante MC. Oxidative stress and BPA toxicity: an antioxidant approach for male and female reproductive dysfunction. Antioxidants. 2020;9(5):405. https://doi.org/10.3390/antiox9050405
  • [8] Kazemi S, Mousavi SN, Aghapour F, Rezaee B, Sadeghi F, Moghadamnia AA. Induction effect of bisphenol A on gene expression involving hepatic oxidative stress in rat. Oxid Med Cell Longev. 2016;2016:6298515. https://doi.org/10.1155/2016/6298515
  • [9] Avci B, Bahadir A, Tuncel OK, Bilgici B. Influence of α-tocopherol and α-lipoic acid on bisphenol-A-induced oxidative damage in liver and ovarian tissue of rats. Toxicol Ind Health. 2016;32(8):1381-1390. https://doi.org/10.1177/0748233714563433
  • [10] Watkins DJ, Peterson KE, Ferguson KK, Mercado-García A, Tamayo y Ortiz M, Cantoral A, Meeker JD, Téllez-Rojo MM. Relating phthalate and BPA exposure to metabolism in peripubescence: the role of exposure timing, sex, and puberty. J Clin Endocrinol. 2016;101(1):79-88. https://doi.org/10.1210/jc.2015-2706
  • [11] Doron S, Snydman DR, Gorbach SL. Lactobacillus GG: bacteriology and clinical applications. Gastroenterol Clin. 2005;34(3):483-498. https://doi.org/10.1016/j.gtc.2005.05.011
  • [12] Segers ME, Lebeer S. Towards a better understanding of Lactobacillus rhamnosus GG-host interactions. Microb Cell Fact. 2014;13(1):1-16. https://doi.org/10.1186/1475-2859-13-S1-S7
  • [13] Liu C-F, Pan T-M. In vitro effects of lactic acid bacteria on cancer cell viability and antioxidant activity. J Food Drug Anal. 2010;18(2):8. https://doi.org/10.38212/2224-6614.2287
  • [14] Zamberlin S, Spehar ID, Kelava N, Samarzija D. Probiotic bacterium Lactobacillus rhamnosus: Beneficial and a diverse effects on human health. Milchwissenschaft. 2012;67(1):30-33.
  • [15] Martarelli D, Verdenelli MC, Scuri S, Cocchioni M, Silvi S, Cecchini C, et al. Effect of a probiotic intake on oxidant and antioxidant parameters in plasma of athletes during intense exercise training. Curr Microbiol. 2011;62:1689-1696. https://doi.org/10.1007/s00284-011-9915-3
  • [16] Pawar SH. Lactobacillus rhamnosus ARJD as a functional food with potential antioxidant and antibacterial abilities. Acta Sci Pharm Sci. 2019;3:63-70. https://doi.org/10.31080/ASPS.2019.03.0341
  • [17] Kleniewska P, Hoffmann A, Pniewska E, Pawliczak R. The influence of probiotic Lactobacillus casei in combination with prebiotic inulin on the antioxidant capacity of human plasma. Oxid Med Cell Longev. 2016;2016:1340903. https://doi.org/10.1155/2016/1340903
  • [18] Çibuk S, Yılmaz H, Mert H, Mis L, Yörük M, Mert N. Effect of Bisphenol-A on oxidative status and certain ınflammatory markers in rats: Experimental study. Türkiye Klin Vet Bil (online). 2023;14(2). https://doi.org/10.5336/vetsci.2023-98134
  • [19] Kabuto H, Hasuike S, Minagawa N, Shishibori T. Effects of bisphenol A on the metabolisms of active oxygen species in mouse tissues. Environ Res. 2003;93(1):31-35. https://doi.org/10.1016/S0013-9351(03)00062-8
  • [20] Amaretti A, Di Nunzio M, Pompei A, Raimondi S, Rossi M, Bordoni A. Antioxidant properties of potentially probiotic bacteria: In vitro and in vivo activities. Appl Microbiol Biotechnol. 2013;97:809-817. https://doi.org/10.1007/s00253-012-4241-7
  • [21] Sun J, Hu XL, Le GW, Shi YH. Lactobacilli prevent hydroxy radical production and inhibit Escherichia coli and Enterococcus growth in system mimicking colon fermentation. Lett Appl Microbiol. 2010;50(3):264-269. https://doi.org/10.1111/j.1472-765X.2009.02786.x
  • [22] Mahdavinia M, Khorsandi L, Alboghobeish S, Samimi A, Dehghani MA, Zeidooni L. Liver histopathological alteration and dysfunction after bisphenol A administration in male rats and protective effects of naringin. Avicenna J Phytomed. 2021;11(4):394. https://doi.org/10.22038/AJP.2021.17649
  • [23] Gualtieri AF, Iwachow MA, Venara M, Rey RA, Schteingart HF. Bisphenol A effect on glutathione synthesis and recycling in testicular Sertoli cells. J Endocrinol Invest. 2011;34:e102-e109. https://doi.org/10.1007/BF03347468
  • [24] Nasonova E. MD Thesis. Mechanisms involved in the cell death in Pc-12 cells and chicken cerebellar neurons under serum deprivation, bisphenol-A exposure and MEHP toxicity, Institute of Biology, University of Oslo, Oslo, Norway 2010. https://www.duo.uio.no/bitstream/handle/10852/11806/Masterthesis-Eugenia-Nasonova.pdf
  • [25] Moghaddam HS, Samarghandian S, Farkhondeh T. Effect of bisphenol A on blood glucose, lipid profile and oxidative stress indices in adult male mice. Toxicol Mech Methods. 2015;25(7):507-513. https://doi.org/10.3109/15376516.2015.1056395
  • [26] Eweda SM, Abdou HM, Abd Elkader H-TAE, El-Gendy AH. Neurotoxicity and neuroinflammatory effects of bisphenol A in male rats: the neuroprotective role of grape seeds proanthocyanidins. Environ Sci Pollut Res Int. 2022;29(6):9257-9268. https://doi.org/10.1007/s11356-021-16311-1
  • [27] Vandenberg LN, Ehrlich S, Belcher SM, Ben-Jonathan N, Dolinoy DC, Hugo ER, Hunt PA, Newbold RR, Rubin BS, Saili KS, Soto AM, Wang H-S, vom Saal FS . Low dose effects of bisphenol A: An integrated review of in vitro, laboratory animal, and epidemiology studies. Endocrine Disrupt. 2013;1(1):e26490. https://doi.org/10.4161/endo.26490
  • [28] Papizadeh M, Nahrevanian H, Rohani M, Hosseini SN, Shojaosadati SA. Lactobacillus rhamnosus Gorbach-Goldin (GG): A top well-researched probiotic strain. J Med Bacteriol. 2016;5(5-6):46-59. https://www.researchgate.net/publication/313221138
  • [29] Beutler E. Nutritional and metabolic aspects of glutathione. Annu Rev Nutr. 1989;9(1):287-302. https://doi.org/10.1146/annurev.nu.09.070189.001443
  • [30] Yagi K. Lipid peroxides and human diseases. Chem Phys Lipids. 1987;45(2-4):337-351. https://doi.org/10.1016/0009-3084(87)90071-5
There are 30 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section Articles
Authors

Pınar Dede

Seren Ede-pazarbaşi This is me

Doğancan Dörücü

Göksel Şener

Tuğba Tunalı-akbay

Publication Date July 5, 2025
Submission Date August 15, 2024
Acceptance Date September 26, 2024
Published in Issue Year 2025 Volume: 29 Issue: 4

Cite

APA Dede, P., Ede-pazarbaşi, S., Dörücü, D., … Şener, G. (2025). Lactobacillus rhamnosus GG alleviates bisphenol-A induced oxidative stress in serum. Journal of Research in Pharmacy, 29(4), 1726-1731. https://doi.org/10.12991/jrespharm.1734682
AMA Dede P, Ede-pazarbaşi S, Dörücü D, Şener G, Tunalı-akbay T. Lactobacillus rhamnosus GG alleviates bisphenol-A induced oxidative stress in serum. J. Res. Pharm. July 2025;29(4):1726-1731. doi:10.12991/jrespharm.1734682
Chicago Dede, Pınar, Seren Ede-pazarbaşi, Doğancan Dörücü, Göksel Şener, and Tuğba Tunalı-akbay. “Lactobacillus Rhamnosus GG Alleviates Bisphenol-A Induced Oxidative Stress in Serum”. Journal of Research in Pharmacy 29, no. 4 (July 2025): 1726-31. https://doi.org/10.12991/jrespharm.1734682.
EndNote Dede P, Ede-pazarbaşi S, Dörücü D, Şener G, Tunalı-akbay T (July 1, 2025) Lactobacillus rhamnosus GG alleviates bisphenol-A induced oxidative stress in serum. Journal of Research in Pharmacy 29 4 1726–1731.
IEEE P. Dede, S. Ede-pazarbaşi, D. Dörücü, G. Şener, and T. Tunalı-akbay, “Lactobacillus rhamnosus GG alleviates bisphenol-A induced oxidative stress in serum”, J. Res. Pharm., vol. 29, no. 4, pp. 1726–1731, 2025, doi: 10.12991/jrespharm.1734682.
ISNAD Dede, Pınar et al. “Lactobacillus Rhamnosus GG Alleviates Bisphenol-A Induced Oxidative Stress in Serum”. Journal of Research in Pharmacy 29/4 (July2025), 1726-1731. https://doi.org/10.12991/jrespharm.1734682.
JAMA Dede P, Ede-pazarbaşi S, Dörücü D, Şener G, Tunalı-akbay T. Lactobacillus rhamnosus GG alleviates bisphenol-A induced oxidative stress in serum. J. Res. Pharm. 2025;29:1726–1731.
MLA Dede, Pınar et al. “Lactobacillus Rhamnosus GG Alleviates Bisphenol-A Induced Oxidative Stress in Serum”. Journal of Research in Pharmacy, vol. 29, no. 4, 2025, pp. 1726-31, doi:10.12991/jrespharm.1734682.
Vancouver Dede P, Ede-pazarbaşi S, Dörücü D, Şener G, Tunalı-akbay T. Lactobacillus rhamnosus GG alleviates bisphenol-A induced oxidative stress in serum. J. Res. Pharm. 2025;29(4):1726-31.