Histopathological changes in the testes of Albino rat exposed to Endosulfan

Year 2025, Volume: 29 Issue: 3, 928 - 936, 04.06.2025

Noor Al-huda R. Mayea , Mukhtar K. Haba

https://doi.org/10.12991/jrespharm.1693756

Abstract

Despite its extremely harmful effects, endosulfan, an organochlorine insecticide, is a commonly used pesticide in agriculture. Consequently, the study's goal was to ascertain how endosulfan affected the albino rats' testes' histology and the effect of that pesticide on the levels of testosterone. The present study was conducted on 32 male albino rats that divided into four groups, control group and three other groups who were administered endosulfan orally at low, medium, and high doses (3.5, 7, and 10.5 mg/kg), respectively for a duration of 15, 30, and 45 days. Results obtained in the current research revealed that there was a significant reduction in the levels of testosterone with an increase in the dose and the duration of exposure to endosulfan with a generation of macrovaculation germinal epithelial cells, degeneration, necrosis, atrophy of certain tubules revealing aspermia and edema, and seminiferous tubule lining cell sloughing. Hormonal properties were also affected by endosulfan treatment. In conclusion, endosulfan after 15, 30 and 45 days of exposure caused significant damage and was harmful to testicular tissue. The current result concludes that hormonal imbalances and oxidative stress may be involved in the harmful effect's process.

Keywords

Endosulfan , histological changes , pesticides , testes , testosterone

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