Penta-acetylchlorogenic acıd for obesity control: A new perspective on chlorogenic acid derivatives

Year 2025, Volume: 29 Issue: 6, 2267 - 2277, 02.11.2025

Faridah Faridah , Dian Ratih Laksmıtawatı , Partomuan Simanjuntak , Shirly Kumala , Intan Permata Sari Eko Mugiyanto

https://doi.org/10.12991/jrespharm.1797754

Abstract

Natural compounds with anti-obesity properties offer promising therapeutic alternatives to synthetic drugs, given their potential for fewer side effects and broader accessibility. Among these compounds, chlorogenic acid (CGA), a polyphenolic compound found in coffee, fruits, and vegetables, has demonstrated significant benefits in weight management and metabolic regulation. This study explores the efficacy of penta-acetyl-chlorogenic acid, an acetylated derivative of chlorogenic acid, as a novel anti-obesity agent. Penta-acetyl-chlorogenic acid (PACA) was synthesized through the Hoffmann method and evaluated for its effects through both in vitro and in silico approaches. The compound demonstrated potent inhibitory effects in vitro via lipase inhibition, with an IC₅₀ of 45.63 μg/ml. The results indicate that acetylation enhances the bioactivity of chlorogenic acid, making PACA a promising candidate for obesity control. Furthermore, in silico docking studies were conducted targeting key proteins associated with obesity, lipase, with binding affinities of -99.50, kcal/mol. Docking results showed strong binding affinities of PACA to these targets, supporting its potential role in modulating lipid metabolism. In summary, this derivative represents a new perspective on the therapeutic potential of chlorogenic acid and its analogs. Further studies are warranted to assess the in vivo relevance of PACA in obesity therapy.

Keywords

Obesity agent , chlorogenic acid derivative , lipase inhibition , molecular docking

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