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Screening of Veterinary Growth-Promoting Agent and Antibacterial Residues in Beef Cattle and Broiler Meats Consumed in Bursa, Turkey

Year 2019, , 52 - 58, 18.07.2019
https://doi.org/10.30782/uluvfd.439782

Abstract

This study was aimed to determine residues of growth-promoting agents and some antibacterials in beef cattle and broiler meats consumed in Bursa, as well as to evaluate their hazards on public health. A total of 45 meat samples consisting of 36 beef cattle meat and 9 broiler meat samples were collected from supermarkets and butchers between November and December in 2016. The analysis was carried out by biochip array-based immunoassay technique. This system is also currently used for simultaneous detection and quantitation of different anabolics consisting of β-agonists, boldenone, corticosteroids, nandrolone, ractopamine, stanozolol, stilbenes, trenbolone and zeranol, and six group of antimicrobials consisting of quinolones, cephalosporins, amphenicols, aminoglycosides, macrolides and tetracyclines. Although residues of growth-promoting agents could not be detected in any of the samples, antimicrobial residues from all groups were detected in 10 beef cattle meat samples and tetracycline residues were detected in two broiler meat samples at various levels. In conclusion, there is no risk to consumers for growth-promoter residues according to the results. The detected antibacterial levels were  generally lower than hazardous concentrations of residue. However, some detected levels for quinolone, amphenicol, macrolide and tetracycline groups in beef meat samples,
and detected concentrations for tetracycline group in two broiler meat samples exceeded the maximum residue limits, and could pose a risk
for public health.

References

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  • 2. Colborn T, Clement C. Advances in modern environmental toxicology: chemically-induced alterations in sexual and functional development. 21th ed. Princeton Scientific Publishing, Princeton, NJ; 1992.
  • 3. Turnipseed SB, Andersen WC, Picó Y, eds. Food Contaminants and Residue Analysis: Comprehensive Analytical Chemistry. 1th ed. 307, Elsevier, Amsterdam; 2008.
  • 4. Martinez-Navarro JF. Food poisoning related to the consumption of illicit β-agonists in liver. Lancet. 1990;336(8726):1311.
  • 5. Pulce C, Lamaison D, Keck G, Bostvironnois C, Nicolas J, Descotes J. Collective human food poisonings by clenbuterol residues in veal liver. Vet Hum Toxicol. 1991;33(5):480-481.
  • 6. Maistro S, Chiesa E, Angeletti R, Brambilla G. Beta blockers to prevent clenbuterol poisoning. Lancet. 1995;346(8968):180.
  • 7. Garay JB, Jime´nez JFH, Jime´nez ML et al. Intoxicacio ´n por clenbuterol: Datos clı´nicos y analı´ticos de un brote epide´mico en Mo´stoles. Rev Clin Esp. Cayci et al. 2019 1997;197:92–95.
  • 8. Brambilla G, Cenci T, Franconi F et al. Clinical and pharmacological profile in a clenbuterol epidemic poisoning of contaminated beef meat in Italy. Toxicol Lett. 2000;114(1-3):47–53.
  • 9. Barbosa J, Cruz C, Martinis J et al. Food poisoning by clenbuterol in Portugal. Food Addit Contam. 2005;22(6):563-566.
  • 10. Reig M, Toldra´ F. Veterinary drug residues in meat: Concerns and rapid methods for detection. Meat Sci. 2008;78(1-2):60–67.
  • 11. Oruç HH, Rumbeiha WK, Ensley S, Olsen C, Schrunk DE. Simultaneous Detection of Six Different Groups of Antimicrobial Drugs in Porcine Oral Fluids Using A Biochip Array-Based Immunoassay. Kafkas Univ Vet Fak Derg. 2013;19(3):407-412.
  • 12. Oruç HH, Rumbeiha WK, Ensley S, Schrunk DE. Simultaneous Detection of Six Different Groups of Antimicrobial Drugs in Milk, Meat, Urine, and Feed Matrices. Uludag Univ J Fac Vet Med. 2013;31(2):29-33.
  • 13. Codex Alimentarius Commission: Maximum Residue Limits (MRLs) and Risk Management Recommendations (RMRs) for Residues of Veterinary Drugs in Foods. 2017;1-43,2-2017.
  • 14. Council Regulation: (EC) No. 37/2010. Laying down a community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin. Off J Eur Commun. 2010;L15,1.
  • 15. Council Directive: 96/22/EC of 29 April 1996. Concerning the prohibition on the use in stock farming of certain substances having a hormonal or thyrostatic action and of beta-agonists, and repealing Directives 81/602/EEC, 88/146/EEC and 88/299/EEC. Off J Eur Union. 1996; L125,3.
  • 16. Turkish Food Codex Regulation. Regulation for certain substances having hormonal and similar acting which prohibited and limited on the use of food-producing animals, Regulation No: 2003/18. (Gıda Değeri Olan Hayvanlara Uygulanması Yasaklanan ve Belli Şartlara Bağlanan Hormon ve Benzeri Maddeler Hakkında Tebliğ), (Tebliğ No): 2003/18.
  • 17. Xu CL, Chu XG, Peng CF, Jin ZY, Wang LY. Development of a faster determination of 10 anabolic steroids residues in animal muscle tissues by liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal. 2006;41(2):616-621.
  • 18. Randox Manual, EV 3726. Growth Promoter Multiple Matrix Screen, 2016.
  • 19. Randox Manual, EV 3524. Antimicrobial Array II, 2016.
  • 20. Salleras L, Dominguez A, Mata E, Taberner JL, Moro I, Salvà P. Epidemiologic of an outbreak of clenbuterol poisoning in Catalonia. Public Health Rep. 1995;110(3):338-342.
  • 21. Brambilla G, Loizzo A, Fontana L, Strozzi M, Guarino A, Soprano V. Food poisoning following consumption of clenbuterol-treated veal in Italy. JAMA. 1997;278(8):635.
  • 22. Shiu TC, Chong WH. A cluster of clenbuterol poisoning associated with pork and pig offal in Hong Kong. Public Health Epidem Bull. 2001;10-14-17.
  • 23. Kuiper HA, Noordam MY, van Dooren-Flipsen MM, Schilt R, Roos AH. Illegal use of beta-adrenergic agonists: European Community. J Anim Sci. 1998;76(1):195-207.
  • 24. Akkaya R, Akıllı A, Gürel Y et al. Türkiye’de yetiştirilen etlik piliçlerin et ve diğer organlarının anabolik hormonlar, beta-agonistler ve pestisidler ile kirlenme durumunun incelenmesi. Etlik Vet Mikrobiyol Derg. 2004;15(1-2):37-38.
  • 25. Oruç HH, Cengiz M, Bağdaş D, Uzunoğlu I. Sığır etlerinde zeranol, dietilstilbestrol, klenbuterol, 17 β-östradiol ve testosteron kalıntıları. Uludag Univ J Fac Vet Med. 2007;26(1-2):11-15.
  • 26. Erdoğdu AT, Koçyiğit Y, Özdemir G, Coşkun Y. Tüketime sunulan sığır ve koyun etlerinde tetrasiklin türevi antibiyotiklerin kalıntılarının belirlenmesi. Bornova Vet Kont Araşt Enst Derg. 2009;31(45):29-33.
  • 27. Cetinkaya F, Yibar A, Soyutemiz GE, Okutan B, Ozcan A, Karaca MY. Determination of tetracycline residues in chicken meat by liquid chromatography-tandem mass spectrometry. Food Addit Contam Part B. 2012;5(1):45–49.
  • 28. Mor F, Şahindokuyucu F, Kav K, Köker A. Sığırların doku örneklerinde zeranol ve trenbolon kalıntılarının belirlenmesi. Eurasian J Vet Sci. 2011;27(4):235-239.
  • 29. Sever E, Okumuş B, İnce S. Erzurum yöresinde satışa sunulan kırmızı etlerde 17 β-östradiol, dietilstilbestrol ve zeranol kalıntılarının araştırılması. Kafkas Univ Vet Fak Derg. 2012;18(2):267-272.
  • 30. Oruç HH, Cengiz M, Bağdaş D, Uzunoğlu I. Sığır etlerinde streptomisin ve sulfametazin (sulfadimidin) kalıntıları. Uludag Univ J Fac Vet Med. 2007;26(1- 2):17-20.
  • 31. Er B, Onurdağ FK, Demirhan B, Ozgacar SÖ, Oktem AB, Abbasoglu U. Screening of quinolone antibiotic residues in chicken meat and beef sold in the markets of Ankara, Turkey. Poult Sci. 2013;92(8):2212-2215.
  • 32. Kadım IT, Mahgoub O, Al-Marzooqi W, Al-Maqbaly R, Annamalı K, Khalaf SK. Enzyme-linked immunosorbent assay for screening antibiotic and hormone residues in broiler chicken meat in the Sultanate of Oman. J Muscle Foods. 2008;21(2):243-254.
  • 33. Sattar S, Hassan MM, Azizul Islam SKM et al. Antibiotic residues in broiler and layer meat in Chittagong district of Bangladesh. Vet World. 2014;7(9):738-743.
Year 2019, , 52 - 58, 18.07.2019
https://doi.org/10.30782/uluvfd.439782

Abstract

References

  • 1. Henderson BE, Ross R, Bernstein L. Estrogens as a cause of human cancer: the richard and hinda rosenthal foundation award lecture. Cancer Res. 1988;48(2):246- 253.
  • 2. Colborn T, Clement C. Advances in modern environmental toxicology: chemically-induced alterations in sexual and functional development. 21th ed. Princeton Scientific Publishing, Princeton, NJ; 1992.
  • 3. Turnipseed SB, Andersen WC, Picó Y, eds. Food Contaminants and Residue Analysis: Comprehensive Analytical Chemistry. 1th ed. 307, Elsevier, Amsterdam; 2008.
  • 4. Martinez-Navarro JF. Food poisoning related to the consumption of illicit β-agonists in liver. Lancet. 1990;336(8726):1311.
  • 5. Pulce C, Lamaison D, Keck G, Bostvironnois C, Nicolas J, Descotes J. Collective human food poisonings by clenbuterol residues in veal liver. Vet Hum Toxicol. 1991;33(5):480-481.
  • 6. Maistro S, Chiesa E, Angeletti R, Brambilla G. Beta blockers to prevent clenbuterol poisoning. Lancet. 1995;346(8968):180.
  • 7. Garay JB, Jime´nez JFH, Jime´nez ML et al. Intoxicacio ´n por clenbuterol: Datos clı´nicos y analı´ticos de un brote epide´mico en Mo´stoles. Rev Clin Esp. Cayci et al. 2019 1997;197:92–95.
  • 8. Brambilla G, Cenci T, Franconi F et al. Clinical and pharmacological profile in a clenbuterol epidemic poisoning of contaminated beef meat in Italy. Toxicol Lett. 2000;114(1-3):47–53.
  • 9. Barbosa J, Cruz C, Martinis J et al. Food poisoning by clenbuterol in Portugal. Food Addit Contam. 2005;22(6):563-566.
  • 10. Reig M, Toldra´ F. Veterinary drug residues in meat: Concerns and rapid methods for detection. Meat Sci. 2008;78(1-2):60–67.
  • 11. Oruç HH, Rumbeiha WK, Ensley S, Olsen C, Schrunk DE. Simultaneous Detection of Six Different Groups of Antimicrobial Drugs in Porcine Oral Fluids Using A Biochip Array-Based Immunoassay. Kafkas Univ Vet Fak Derg. 2013;19(3):407-412.
  • 12. Oruç HH, Rumbeiha WK, Ensley S, Schrunk DE. Simultaneous Detection of Six Different Groups of Antimicrobial Drugs in Milk, Meat, Urine, and Feed Matrices. Uludag Univ J Fac Vet Med. 2013;31(2):29-33.
  • 13. Codex Alimentarius Commission: Maximum Residue Limits (MRLs) and Risk Management Recommendations (RMRs) for Residues of Veterinary Drugs in Foods. 2017;1-43,2-2017.
  • 14. Council Regulation: (EC) No. 37/2010. Laying down a community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin. Off J Eur Commun. 2010;L15,1.
  • 15. Council Directive: 96/22/EC of 29 April 1996. Concerning the prohibition on the use in stock farming of certain substances having a hormonal or thyrostatic action and of beta-agonists, and repealing Directives 81/602/EEC, 88/146/EEC and 88/299/EEC. Off J Eur Union. 1996; L125,3.
  • 16. Turkish Food Codex Regulation. Regulation for certain substances having hormonal and similar acting which prohibited and limited on the use of food-producing animals, Regulation No: 2003/18. (Gıda Değeri Olan Hayvanlara Uygulanması Yasaklanan ve Belli Şartlara Bağlanan Hormon ve Benzeri Maddeler Hakkında Tebliğ), (Tebliğ No): 2003/18.
  • 17. Xu CL, Chu XG, Peng CF, Jin ZY, Wang LY. Development of a faster determination of 10 anabolic steroids residues in animal muscle tissues by liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal. 2006;41(2):616-621.
  • 18. Randox Manual, EV 3726. Growth Promoter Multiple Matrix Screen, 2016.
  • 19. Randox Manual, EV 3524. Antimicrobial Array II, 2016.
  • 20. Salleras L, Dominguez A, Mata E, Taberner JL, Moro I, Salvà P. Epidemiologic of an outbreak of clenbuterol poisoning in Catalonia. Public Health Rep. 1995;110(3):338-342.
  • 21. Brambilla G, Loizzo A, Fontana L, Strozzi M, Guarino A, Soprano V. Food poisoning following consumption of clenbuterol-treated veal in Italy. JAMA. 1997;278(8):635.
  • 22. Shiu TC, Chong WH. A cluster of clenbuterol poisoning associated with pork and pig offal in Hong Kong. Public Health Epidem Bull. 2001;10-14-17.
  • 23. Kuiper HA, Noordam MY, van Dooren-Flipsen MM, Schilt R, Roos AH. Illegal use of beta-adrenergic agonists: European Community. J Anim Sci. 1998;76(1):195-207.
  • 24. Akkaya R, Akıllı A, Gürel Y et al. Türkiye’de yetiştirilen etlik piliçlerin et ve diğer organlarının anabolik hormonlar, beta-agonistler ve pestisidler ile kirlenme durumunun incelenmesi. Etlik Vet Mikrobiyol Derg. 2004;15(1-2):37-38.
  • 25. Oruç HH, Cengiz M, Bağdaş D, Uzunoğlu I. Sığır etlerinde zeranol, dietilstilbestrol, klenbuterol, 17 β-östradiol ve testosteron kalıntıları. Uludag Univ J Fac Vet Med. 2007;26(1-2):11-15.
  • 26. Erdoğdu AT, Koçyiğit Y, Özdemir G, Coşkun Y. Tüketime sunulan sığır ve koyun etlerinde tetrasiklin türevi antibiyotiklerin kalıntılarının belirlenmesi. Bornova Vet Kont Araşt Enst Derg. 2009;31(45):29-33.
  • 27. Cetinkaya F, Yibar A, Soyutemiz GE, Okutan B, Ozcan A, Karaca MY. Determination of tetracycline residues in chicken meat by liquid chromatography-tandem mass spectrometry. Food Addit Contam Part B. 2012;5(1):45–49.
  • 28. Mor F, Şahindokuyucu F, Kav K, Köker A. Sığırların doku örneklerinde zeranol ve trenbolon kalıntılarının belirlenmesi. Eurasian J Vet Sci. 2011;27(4):235-239.
  • 29. Sever E, Okumuş B, İnce S. Erzurum yöresinde satışa sunulan kırmızı etlerde 17 β-östradiol, dietilstilbestrol ve zeranol kalıntılarının araştırılması. Kafkas Univ Vet Fak Derg. 2012;18(2):267-272.
  • 30. Oruç HH, Cengiz M, Bağdaş D, Uzunoğlu I. Sığır etlerinde streptomisin ve sulfametazin (sulfadimidin) kalıntıları. Uludag Univ J Fac Vet Med. 2007;26(1- 2):17-20.
  • 31. Er B, Onurdağ FK, Demirhan B, Ozgacar SÖ, Oktem AB, Abbasoglu U. Screening of quinolone antibiotic residues in chicken meat and beef sold in the markets of Ankara, Turkey. Poult Sci. 2013;92(8):2212-2215.
  • 32. Kadım IT, Mahgoub O, Al-Marzooqi W, Al-Maqbaly R, Annamalı K, Khalaf SK. Enzyme-linked immunosorbent assay for screening antibiotic and hormone residues in broiler chicken meat in the Sultanate of Oman. J Muscle Foods. 2008;21(2):243-254.
  • 33. Sattar S, Hassan MM, Azizul Islam SKM et al. Antibiotic residues in broiler and layer meat in Chittagong district of Bangladesh. Vet World. 2014;7(9):738-743.
There are 33 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Research Articles
Authors

Meltem Caycı 0000-0002-3401-9186

Ayşe Sena Kılıç 0000-0001-6430-5629

Hasan Huseyin Oruc This is me 0000-0002-5399-2395

Rashad Sarıyev This is me 0000-0002-1129-4118

Publication Date July 18, 2019
Published in Issue Year 2019

Cite

APA Caycı, M., Kılıç, A. S., Oruc, H. H., Sarıyev, R. (2019). Screening of Veterinary Growth-Promoting Agent and Antibacterial Residues in Beef Cattle and Broiler Meats Consumed in Bursa, Turkey. Journal of Research in Veterinary Medicine, 38(1), 52-58. https://doi.org/10.30782/uluvfd.439782
AMA Caycı M, Kılıç AS, Oruc HH, Sarıyev R. Screening of Veterinary Growth-Promoting Agent and Antibacterial Residues in Beef Cattle and Broiler Meats Consumed in Bursa, Turkey. J Res Vet Med. July 2019;38(1):52-58. doi:10.30782/uluvfd.439782
Chicago Caycı, Meltem, Ayşe Sena Kılıç, Hasan Huseyin Oruc, and Rashad Sarıyev. “Screening of Veterinary Growth-Promoting Agent and Antibacterial Residues in Beef Cattle and Broiler Meats Consumed in Bursa, Turkey”. Journal of Research in Veterinary Medicine 38, no. 1 (July 2019): 52-58. https://doi.org/10.30782/uluvfd.439782.
EndNote Caycı M, Kılıç AS, Oruc HH, Sarıyev R (July 1, 2019) Screening of Veterinary Growth-Promoting Agent and Antibacterial Residues in Beef Cattle and Broiler Meats Consumed in Bursa, Turkey. Journal of Research in Veterinary Medicine 38 1 52–58.
IEEE M. Caycı, A. S. Kılıç, H. H. Oruc, and R. Sarıyev, “Screening of Veterinary Growth-Promoting Agent and Antibacterial Residues in Beef Cattle and Broiler Meats Consumed in Bursa, Turkey”, J Res Vet Med, vol. 38, no. 1, pp. 52–58, 2019, doi: 10.30782/uluvfd.439782.
ISNAD Caycı, Meltem et al. “Screening of Veterinary Growth-Promoting Agent and Antibacterial Residues in Beef Cattle and Broiler Meats Consumed in Bursa, Turkey”. Journal of Research in Veterinary Medicine 38/1 (July 2019), 52-58. https://doi.org/10.30782/uluvfd.439782.
JAMA Caycı M, Kılıç AS, Oruc HH, Sarıyev R. Screening of Veterinary Growth-Promoting Agent and Antibacterial Residues in Beef Cattle and Broiler Meats Consumed in Bursa, Turkey. J Res Vet Med. 2019;38:52–58.
MLA Caycı, Meltem et al. “Screening of Veterinary Growth-Promoting Agent and Antibacterial Residues in Beef Cattle and Broiler Meats Consumed in Bursa, Turkey”. Journal of Research in Veterinary Medicine, vol. 38, no. 1, 2019, pp. 52-58, doi:10.30782/uluvfd.439782.
Vancouver Caycı M, Kılıç AS, Oruc HH, Sarıyev R. Screening of Veterinary Growth-Promoting Agent and Antibacterial Residues in Beef Cattle and Broiler Meats Consumed in Bursa, Turkey. J Res Vet Med. 2019;38(1):52-8.