Effect of Long-Term Centrally Injected Histamine and Its Receptors Antagonist on The Hypothalamic Cyclooxygenase and Lipoxygenase Enzymes in Rats

Year 2019, , 10 - 16, 18.12.2019

Aysenur Baş , Gokcen Guvenc Bayram Burcin Altinbas , Ebru Ozyurt , Ebru Yalcin , Burcu Erbaykent Tepedelen Figen Ersoy , Murat Yalçın

https://doi.org/10.30782/jrvm.606895

Abstract

The current study was designed to determine the effect of centrally chronic-administrated
histamine and histaminergic receptors antagonist on the hypothalamic
cyclooxygenase (COX) and lipoxygenase (LOX) enzymes amount.

Studies were performed in male Sprague–Dawley rats. Histamine (100 nmol),
histaminergic H1 receptor antagonist chlorpheniramine (100 nmol), histaminergic
H2 receptor antagonist ranitidine (100 nmol) or histaminergic H3/H4 receptor
antagonist thioperamide (100 nmol) was injected intracerebroventricularly for 7
days. Central chronic histamine treatment caused an increase in all three
enzymes amount in the hypothalamus. Histaminergic receptors antagonist chronic-treatments
with chlorpheniramine, ranitidine and thioperamide produced to decrease in
hypothalamic COX-1 amount and to increase in hypothalamic COX-2 and LOX
amounts.

In conclusion, our findings show that the central histaminergic
system has a potential for effect the central COX and LOX pathways. This could
be interpreted that central histaminergic and central COX and LOX pathways have
an interaction to regulate in many central nervous system functions.

Keywords

Histamine, Histaminergic receptors, Hypothalamus, Cyclooxygenase, Lipoxygenase, Intracerebroventricular, Western blot

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