Araştırma Makalesi
BibTex RIS Kaynak Göster

The effect of aspirin on tissue malondialdehyde level in azoxymethane-induced colon carcinogenesis

Yıl 2020, Cilt: 13 Sayı: 1, 16 - 21, 01.01.2020

Öz

It has been demonstrated that nonsteroidal anti-inflammatory drug (NSAID)’s releasing prostaglandin inhibition, created some degree of suppression in the carcinogenesis of the colon. Many recent studies have been directed to underline the mechanism of the preventive effect of NSAID’s and especially aspirin in colonic carcinogenesis. The most frequent subject among these studies is the mutagenic effect of arachidonic acid metabolites. Malondialdehyde (MDA) is the product of arachidonic acid metabolism whose mutagenic effect has been shown, and MDA production can be prevented by cyclooxygenase inhibition.
We performed an experimental study to demonstrate the effect of aspirin on the tissue MDA in colonic carcinogenesis. The study is built into four groups, consisting of ten rats each. Group 1: Control group; serum physiologic group, equal volumes to azoxymethane (AOM) is given two weeks subcutaneously, once every week. Group 2: AOM group; 15 mg/kg/week AOM is given subcutaneously for two weeks. Group 3: AOM + 1.4 mg/kg/day aspirin group; following the last dose of AOM, 1.4 mg/kg/day aspirin added to daily fluid doses. Group 4: AOM +5 mg/kg/day Aspirin group; following the last dose of AOM 5 mg/kg/day aspirin is added to the daily fluid doses. Fifty-two weeks after the last AOM dose laparotomy was performed on all the rats. The number, location, and dimension of all two moral masses in all groups were examined. Tumor volumes were calculated. The histopathologic examinations were done and both of the tumor and normal mucosa MDA measures were studied.
According to the results, mucosa MDA measures were significantly higher in the other groups than group 1 (p<0.05). On the other hand, there was a significant difference between groups 2-4 (p=0.03) whether there wasn’t a significant difference between groups 2 and 3. When tumor MDA measures have been studied, there wasn’t a difference between 2 and 3, but the measures which have been established for group 4 were lower than either in group 2 or group 3 (p=0.02, p=0.001). Tumor volumes in group 2 were significantly higher than both of group 3 and group 4 (p=0.0009, p=0.0012).
These results demonstrate that NSAIDs and aspirin have prevention effects on colonic carcinogenesis. However, there is no agreement about how the drugs affect the carcinogenesis. In this study, decreasing mutagenic activity which is linked to MDA, is one of the mechanisms that has been proved. Furthermore, it has been showed that this effect happens at anti analgesic doses

Yıl 2020, Cilt: 13 Sayı: 1, 16 - 21, 01.01.2020

Öz

Toplam 0 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi
Bölüm Araştırma Makalesi
Yazarlar

Emine Özlem Gür Bu kişi benim

Atilla Çökmez Bu kişi benim

Akif Serhat Gür Bu kişi benim

Cüneyt Akaoğlu Bu kişi benim

Ercüment Tarcan Bu kişi benim

Sümer Deniz Bu kişi benim

Yayımlanma Tarihi 1 Ocak 2020
Gönderilme Tarihi 17 Nisan 2019
Yayımlandığı Sayı Yıl 2020 Cilt: 13 Sayı: 1

Kaynak Göster

Vancouver Gür EÖ, Çökmez A, Gür AS, Akaoğlu C, Tarcan E, Deniz S. The effect of aspirin on tissue malondialdehyde level in azoxymethane-induced colon carcinogenesis. JSurgArts. 2020;13(1):16-21.

Journal of Surgical Arts (Cerrahi Sanatlar Dergisi, ISSN:1308-0709) is indexed with, or included in, the following;  OJS, DOAJ, CROSSREF, EBSCO Host, Google Scholar, CiteFactor, MIAR Index, EuroPub Database, CABELLS, Dergipark (TUBİTAK), Türkiye Citation Index, Sobiad, Asos Index, İdeal Index, and Akademik Index.

Note: The Journal of Surgical Arts is within the scope of the journals scanned by the international indexes (EBSCO, DOAJ,..) defined by "Interuniversity Board" (YÖK, Türkiye).

Submission: When submitting an article, you will be directed to DergiPark (Journal of Surgical Arts » Home (dergipark.org.tr), which is a Hosting and Manuscript tracking service provider. You will be able to log in easily with the username and password you set.