Araştırma Makalesi
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Yıl 2018, Cilt: 2 Sayı: 2, 61 - 72, 01.05.2018

Öz

Kaynakça

  • REFERENCESAIMO,L., OTEIZA,P.I., 2006, Zinc Deficiency Increases the Susceptibility of Human Neuroblastoma Cells to Lead-Induced Activator Protein-1 Activation. Toxicol Sci, 91, 184–191. BIELARCZYK,H., TOMASZEWICZ,M., SZUTOWICZ,A., 1998, Effect of Aluminum on Acetyl-CoA and Acetylcholine Metabolism in Nerve Terminals. J Neurochem, 70(3), 1175–1181. CARR,B.R., BLACKWELL,R.E., 1998, Textbook of Reproductive Medicine, Stamford, CT, Appleton & Lange.CHEN,L., WANG Y., KAIRAITIS,L.K., ZHANG,B.H., HARRIS,D.C., 2001, Molecular Mechanisms by which Iron Induces Nitric Oxide Synthesis in Cultured Proximal Tubule Cells. Exp Nephrol, 9(3), 198-204. CHETTY,C.S., REDDY,G.R., MURTHY,K.S., JOHNSON,J., SAJWAN,K., DESAİAH D., 2001, Perinatal Lead Exposure Alters the Expression of Neuronal Nitric Oxide Synthase in Rat Brain. Int J Toxicol,20, 113–120. CORY-SLECHTA,D.A., POKORA,M.J., WIDZOWSKI,D.V., 1992, Postnatal Lead Exposure Induces Supersensitivity to the Stimulus Properties of a D2–D3 Agonist. Brain Res,598, 162–172. COSTAC.A., TRIVELATO G.C., PINTO A.M., BECHARA E.J., 1997, Correlation between Plasma 5 Aminolevulinic Acid Concentrations and Indicators of Oxidative Stress in Lead-Exposed Workers. Clin Chem, 43 (7), 1196–1202.CUI L., TAKAGI Y., WASA M., IIBOSHI Y., KHAN J., NEZU R., OKADA A., 1997, Induction of Nitric Oxide Synthase in Rat Intestine by Interleukin-1 Alpha May Explain Diarrhea Assciated with Zinc Deficiency. J Nutr,127, 1729-1736. CUZZOCREA S., PERSICHINI T., DUGO L., COLASANTI M., MUSCI G., 2003, CopperInduces Type II Nitric Oxide Synthase in Vitro. Free Radical Biol Med, 34(10), 1253-1262. DEMIR N.,GEZEN M.R., BALLI M., 2011, Çanakkale Boğazı’nın Karacaören Kıyısındaki Deniz Suyu ve Bazı Yumuşakçalarda (Bivalvia ve Gastropoda) Ağır Metal Düzeylerinin Araştırılması. Ekoloji Sempozyumu, Düzce, 177. DEVI C.B., REDDY G.H., PRASANTHI R.P., CHETTY C.S., REDDY G.R, 2005, DevelopmentalLead Exposure Alters Mitochondrial Monoamine Oxidase and Synaptosomal Catecholamine Levels in Rat Brain. Int J Dev Neurosci, 23, 375–381. DEVI S.S., BISWAS A.R., BISWAS R.A., VINAYAGAMOORTHY N., KRISHNAMURTHI K., SHINDE V.M., HENGSTLER J.G., HERMES M., CHAKRABARTI T., 2007, Heavy Metal Status and Oxidative Stress in Diesel Engine Tuning Workers of Central Indian Population. J Occup Environ Med,49(11): 1228-1234. DING Y., VAZIRI N.D., GONICK H.C.,1998, Lead-Induced Hypertension. II. Response to Sequential Infusions of L-Arginine, Superoxide Sismutase, and Sitroprusside. Environmental Research, 76(2), 107–113.DING Y., GONICK H.C., VAZIRI N.D., 2000, Lead Promotes Hydroxyl Radical Generation and Lipid Peroxidation in Cultured Aortic Endothelial Cells. The American Journal of Hypertension,13(5), 552–555. DUBAS T.C., HRDINA P.D., 1978, Behavioural and Neurochemical Consequences of Neonatal Exposure to Lead in Rats. J Environ Pathol Toxicol, 2, 471–484.FOWLER B.A., WHITTAKER M.H., LIPSKY M., WANG G., CHEN X.Q., 2004, Oxidative Stress Induced by Lead, Cadmium and Arsenic Mixtures: 30-day, 90-day, and 180-day Drinking Water Studies in Rats: AnOverview. BioMetals, 17(5), 567–568.

iNOS IMMUNOREACTIVITY IN THE OVARIES OF RATS FEEDING WITH MUSSEL (Mytilus galloprovincialis)

Yıl 2018, Cilt: 2 Sayı: 2, 61 - 72, 01.05.2018

Öz

The ovary is an endocrine and exocrine gland that plays primary role in female development and reproductive activities. The seamen are collecting a lot of heavy metals by serving as filters in the seas. Since the last decades of the nineteenth century and until today, the study of the consequences of human exposure to heavy metals has risen as a central research area in the toxicological field. Among the group of metals with proven human toxicity aluminium (Al) and lead (Pb) are known to be highly neurotoxic. The Mediterranean mussel (Mytilus galloprovincialis) is a species of bivalve, a marine mollusc in the family Mytilidae. In our previous researches, we found Al, zinc (Zn) and iron (Fe) values were higher in mussels taken from Çamburnu region of the Dardanelles. In many tumors, inducible nitric oxide synthase (iNOS) expression is high, however, the role of iNOS during tumor development is very complex and quite perplexing, with both promoting and inhibiting actions having been described. The purpose of the study is to demonstrate the iNOS immunoreactivity in the ovarian tissues of rats which are fed with mussels that are collected from the Çamburnu region of the Dardanelles. The mussels given as food to the rats were removed from the Çamburnu region of the Dardanelles. Average 100±10 g weight were selected.  After the beaks were overcooked, the meat broke off and the meat at 100 degrees was dried. Two groups of rats are included in the study, group 1 (n=6), control group fed with standard rat food, group 2 (n=6), 90%  mussels and 10% standard rat food daily. To detect iNOS localization in the tissues, the LAB-SA Detection System was used. iNOS immunoreactivity was detected in the interstitial cell cytoplasm of the ovaries of rats fed with mussel.  iNOS immunoreactivity was also observed in germ cell cytoplasm in some primordial follicles. There was statistically significant difference between the iNOS immunoreactivity of the interstitial cells in the ovarian parenchyma of the rats in the experimental and control groups (p> 0.05).

Kaynakça

  • REFERENCESAIMO,L., OTEIZA,P.I., 2006, Zinc Deficiency Increases the Susceptibility of Human Neuroblastoma Cells to Lead-Induced Activator Protein-1 Activation. Toxicol Sci, 91, 184–191. BIELARCZYK,H., TOMASZEWICZ,M., SZUTOWICZ,A., 1998, Effect of Aluminum on Acetyl-CoA and Acetylcholine Metabolism in Nerve Terminals. J Neurochem, 70(3), 1175–1181. CARR,B.R., BLACKWELL,R.E., 1998, Textbook of Reproductive Medicine, Stamford, CT, Appleton & Lange.CHEN,L., WANG Y., KAIRAITIS,L.K., ZHANG,B.H., HARRIS,D.C., 2001, Molecular Mechanisms by which Iron Induces Nitric Oxide Synthesis in Cultured Proximal Tubule Cells. Exp Nephrol, 9(3), 198-204. CHETTY,C.S., REDDY,G.R., MURTHY,K.S., JOHNSON,J., SAJWAN,K., DESAİAH D., 2001, Perinatal Lead Exposure Alters the Expression of Neuronal Nitric Oxide Synthase in Rat Brain. Int J Toxicol,20, 113–120. CORY-SLECHTA,D.A., POKORA,M.J., WIDZOWSKI,D.V., 1992, Postnatal Lead Exposure Induces Supersensitivity to the Stimulus Properties of a D2–D3 Agonist. Brain Res,598, 162–172. COSTAC.A., TRIVELATO G.C., PINTO A.M., BECHARA E.J., 1997, Correlation between Plasma 5 Aminolevulinic Acid Concentrations and Indicators of Oxidative Stress in Lead-Exposed Workers. Clin Chem, 43 (7), 1196–1202.CUI L., TAKAGI Y., WASA M., IIBOSHI Y., KHAN J., NEZU R., OKADA A., 1997, Induction of Nitric Oxide Synthase in Rat Intestine by Interleukin-1 Alpha May Explain Diarrhea Assciated with Zinc Deficiency. J Nutr,127, 1729-1736. CUZZOCREA S., PERSICHINI T., DUGO L., COLASANTI M., MUSCI G., 2003, CopperInduces Type II Nitric Oxide Synthase in Vitro. Free Radical Biol Med, 34(10), 1253-1262. DEMIR N.,GEZEN M.R., BALLI M., 2011, Çanakkale Boğazı’nın Karacaören Kıyısındaki Deniz Suyu ve Bazı Yumuşakçalarda (Bivalvia ve Gastropoda) Ağır Metal Düzeylerinin Araştırılması. Ekoloji Sempozyumu, Düzce, 177. DEVI C.B., REDDY G.H., PRASANTHI R.P., CHETTY C.S., REDDY G.R, 2005, DevelopmentalLead Exposure Alters Mitochondrial Monoamine Oxidase and Synaptosomal Catecholamine Levels in Rat Brain. Int J Dev Neurosci, 23, 375–381. DEVI S.S., BISWAS A.R., BISWAS R.A., VINAYAGAMOORTHY N., KRISHNAMURTHI K., SHINDE V.M., HENGSTLER J.G., HERMES M., CHAKRABARTI T., 2007, Heavy Metal Status and Oxidative Stress in Diesel Engine Tuning Workers of Central Indian Population. J Occup Environ Med,49(11): 1228-1234. DING Y., VAZIRI N.D., GONICK H.C.,1998, Lead-Induced Hypertension. II. Response to Sequential Infusions of L-Arginine, Superoxide Sismutase, and Sitroprusside. Environmental Research, 76(2), 107–113.DING Y., GONICK H.C., VAZIRI N.D., 2000, Lead Promotes Hydroxyl Radical Generation and Lipid Peroxidation in Cultured Aortic Endothelial Cells. The American Journal of Hypertension,13(5), 552–555. DUBAS T.C., HRDINA P.D., 1978, Behavioural and Neurochemical Consequences of Neonatal Exposure to Lead in Rats. J Environ Pathol Toxicol, 2, 471–484.FOWLER B.A., WHITTAKER M.H., LIPSKY M., WANG G., CHEN X.Q., 2004, Oxidative Stress Induced by Lead, Cadmium and Arsenic Mixtures: 30-day, 90-day, and 180-day Drinking Water Studies in Rats: AnOverview. BioMetals, 17(5), 567–568.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Health Sciences
Yazarlar

Mehmet Rıza Gezen

Yayımlanma Tarihi 1 Mayıs 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 2 Sayı: 2

Kaynak Göster

APA Gezen, M. R. (2018). iNOS IMMUNOREACTIVITY IN THE OVARIES OF RATS FEEDING WITH MUSSEL (Mytilus galloprovincialis). Journal of Scientific Perspectives, 2(2), 61-72.