MIXTURES of PHARMACEUTICALS and PERSONAL CARE PRODUCTS (PPCPs) EFFECT PLANT STRESS MARKERS and NUTRIENT UPTAKE in WHEAT and BARLEY

Yıl 2022, Sayı: 048, 1 - 13, 31.03.2022

Müjgan Elveren Etem Osma

Öz

Common drug active substances (gemfibrozil, β-estradiol, caffeine, and ciprofloxacin) were combined in simple mixtures and applied to soil containing wheat or barley. Mixtures in water (50 μg/mL) were applied twice during the growing period. Harvested plant samples were extracted and antioxidant enzyme activities, as indicated by CAT, POD, and SOD were compared in exposed and control plants. Lipid peroxidation markers were also determined. Finally, mineral element uptake in exposed and control plants was determined. The data indicated differences in several, if not all, of the plant biomarkers between control plants and those treated with simple mixtures of pharmaceutical substances; many were directly related to oxidative damage. It was determined that there were statistically significant differences in the element intake of 8 nutrients (magnesium, potassium, phosphorus, calcium, zinc, mangan, copper, and iron) in control plants compared with plants treated with PPCPs; we observed both increases and decreases in plant nutrients depending on the particular nutrient, pharmaceutical treatment, and plant species.

Anahtar Kelimeler

Antioxidiant Enzymes, Barley, Mineral Element, PPCPs, Wheat

Proje Numarası

FBA-2017-404.

Kaynakça

• [1] Daughton, C.G., Ternes, T.A., (1999), Pharmaceuticals and personal care products in the environment: agents of subtle change, Environmental Health Perspectives, 107, 907-938.
• [2] Wang, J., Wang, S., (2016), Removal of pharmaceuticals and personal care products (PPCPs) from wastewater: a review, Journal of Environment Management, 182, 620-640.
• [3] Bartrons, M, Peñuelas, J., (2017), Pharmaceuticals and personal-care products in plants, Trends in Plant Science, 22(3), 194-203.
• [4] Anonymous,(2018), http://www.ieis.org.tr/ieis/assets/media/Raporlar/TR_Sektor_raporu_2016.pdf
• [5] Verlicchi, P., Al Aukidy, M., Jelic, A., Petrović, M., Barceló, D., (2014), Comparison of measured and predicted concentrations of selected pharmaceuticals in wastewater and surface water: a case study of a catchment area in the Po Valley (Italy), Science Total Environment, 470-471, 844-854.
• [6] Wu, X., Conkle, J.L., Gan, J., (2012), Multi-residue determination of pharmaceutical and personal care products in vegetables, Journal of Chromatography A., 1254, 78-86.
• [7] Dolliver, H., Kumar, K., Gupta, S., (2007), Sulfamethazine uptake by plants from manure-amended soil, Journal of Environmental Quality, 36, 1224-1230.
• [8] Chitescu, C.L., Nicolau, A.I., Stolker, A.A.M., (2013), Uptake of oxytetracycline, sulfamethoxazole and ketoconazole from fertilised soils by plants, Food Additives & Contaminants: Part A., 30, 1138-1146.
• [9] Ahmed, M.B.M., Rajapaksha, A.U., Lim, J.E., Vu, N.T., Kim, I.S., Kang, H.M., Lee, S.S., Ok, Y.S., (2015), Distribution and accumulative pattern of tetracyclines and sulfonamides in edible vegetables of cucumber, tomato, and lettuce, Journal of Agricultural and Food Chemistry, 63, 398-405.
• [10] Azanu, D., Mortey, C., Darko, G., Weisser, J.J., Styrishave, B., Abaidoo, R.C., (2016), Uptake of antibiotics from irrigation water by plants, Chemosphere, 157, 107-114.
• [11] Mittler, R., (2002), Oxidative stress, antioxidants and stress tolerance, Trends in Plant Science, 7, 405-410.
• [12] Sun, C., Dudley, S., Trumble, J., Gan, J., (2018), Pharmaceutical and personal care products-induced stress symptoms and detoxification mechanisms in cucumber plants, Environmental Pollution, 234, 39-47.
• [13] Osma, E., Cigir, Y., Karnjanapiboonwong, A., Anderson, T.A., (2018), Evaluation of selected pharmaceuticals on plant stress markers in wheat, International Journal of Environmental Research, 12(2), 179-188.
• [14] Winker, M., Clemens, J., Reich, M., Gulyas, H., Otterpohl, R., (2010), Ryegrass uptake of carbamazepine and ibuprofen applied by urine fertilization, Science Total Environment, 408, 1902-1908.
• [15] Carvalho, P.N., Basto, M.C.P., Almeida, C.M.R., Brix, H., (2014), A review of plant–pharmaceutical interactions: from uptake and effects in crop plants to phytoremediation in constructed wetlands, Environmental Science and Pollution Research, 21, 11729-11763.
• [16] Peñuelas, J., Terradas, J., (2014), The foliar microbiome, Trends in Plant Science, 19, 278-280.
• [17] Peñuelas, J., Farré-Armengol, G., Llusia, J., Gargallo-Garriga, A., Rico, L., Sardans, J., Terradas, J., Filella, I., (2014), Removal of floral microbiota reduces floral terpene emissions, Scientific Reports, 4, 6727.
• [18] Ananieva, E.A., Alexieva, V.S., Popova, LP., (2002), Treatment with salicylic acid decreases the effects of paraquat on photosynthesis, Journal of Plant Physiology, 159(7), 685-693.
• [19] Griffith, M., Ala, P., Yang, D.S.C., Hon, W.C., Moffatt, B.A., (1992), Antifreeze protein produced endogenously in winter rye leaves, Plant Physiology, 100, 593-596.
• [20] Türkoğlu, E., Osma, E., Elveren, M., (2019), Effects of acetaminophen (paracetamol) and gemfibrozil on seed development and antioxidant enzyme activities in different wheat varieties, Iranian Journal of Science and Technology, Transactions A: Science, 43, 2075–2082.
• [21] Upadhyaya, A., Sankhla, D., Davis, N., Sankhla, N., Smith, B.N., (1985), Effect of paclobutrazol on the activities of some enzymes of activated oxygen metabolism and lipid peroxidation in senescing soybean leaves, Journal of Plant Physiology, 121, 453-461.
• [22] Demirezen, D., Aksoy, A., (2006), Heavy metal levels in vegetables in Turkey is within safe limits for Cu, Zn, Ni and exceeded for Cd and Pb, Journal of Food Quality, 29, 252-265.
• [23] Osma, E., İlhan, V., Yalçın, İ.E., (2014), Heavy metals accumulation causes toxicological effects in aquatic Typha domingensis Pers., Brazilian Journal of Botany, 37(4), 461-467.
• [24] Tai, Y., Luo, X., Mo, C., Li, Y., Wu, X., Liu, X., (2011), Occurrence of quinolone and sulfonamide antibiotics in swine and cattle manures from large-scale feeding operations of Guangdong province, Huanjing Kexue, 32, 1188–1193.
• [25] Awad, Y.M., Kim, S.C., Abd El-Azeem, S.A.M., Kim, K.H., Kim, K.R., Kim, K., Jeon, C., Lee, S.S., Ok, Y.S., (2014), Veterinary antibiotics contamination in water, sediment, and soil near a swine manure composting facility, Environmental Earth Sciences, 71, 1433–1440.
• [26] Sura, S., Degenhardt, D., Cessna, A.J., Larney, F.J., Olson, A.F., McAllister, T.A., (2014), Dissipation of three veterinary antimicrobials in beef cattle feedlot manure stockpiled over winter, Journal of Environmental Quality, 43, 1061–1070.
• [27] Dodgen, L.K., Li, J., Parker, D., Gan, J.J., (2013), Uptake and accumulation of four PPCP/EDCs in two leafy vegetables, Environmental Pollution, 182, 150-156.
• [28] An, J., Zhoua, Q., Suna, F., Zhanga, L., (2009), Ecotoxicological effects of paracetamol on seed germination and seedling development of wheat (Triticum aestivum L.), Journal of Hazardous Materials, 169, 751–757.
• [29] Kummerova M, Zezuka S, Babula P, Triska J., (2016), Possible ecologial risk of two pharmaceuticals diclofenac and paracetamol demonstrated on a model plant Lemma minor, Journal of Hazardous Materials, 302, 351–361.
• [30] Pietrini, F., Baccioa, D.D., Acena,˜ J., Pérez, S., Barceló, D., Zacchini, M., (2015), Ibuprofen exposure in Lemna gibba L.: Evaluation of growth and phytotoxic indicators, detection of ibuprofen and identification of its metabolites in plant and in the medium, Journal of Hazardous Materials, 300, 189–193.
• [31] Christou, A., Antoniou, C., Christodoulou, C., Hapeshi, E., Stavrou, J., Michael, C., Fatta-Kassinos, D., Fotopoulos, V., (2016), Stress-related phenomena and detoxification mechanisms induced bycommon pharmaceuticals in alfalfa (Medicago sativa L.) plants, Science Total Environment, 557–558, 652–664.
• [32] Geiger, E., Hornek-Gausterer, R., Saçan, M.T., (2016), Single and mixture toxicity of pharmaceuticals and chlorophenols to fresh water algae Chlorella vulgaris, Ecotoxicology and Environmental Safety, 129, 189–198.