2-AMİNOBENZİMİDAZOLÜN METAL KOMPLEKSLERİ ve BİYOLOJİK ÖZELLİKLERİ

Yıl 2021, Sayı: 004, 19 - 28, 30.12.2021

Halil İlkimen Sabiha Gözde Salün Birsel İlkimen

Öz

2-Aminobenzimidazol ve türevlerin, antibakteriyel, antikanser, antiviral, antiinflamatuvar, antiproliferatif, antifungal, antelmintik ve antihistaminik özelliklere sahip olduğu çalışmalar literatürde bulunmaktadır. 2-Aminobenzimidazol ve türevleri yapısında üç adet azot atomlarından dolayı metal iyonlarına bir ve iki dişli olarak bağlanmaktadır. 2-Aminobenzimidazol ve türevlerinin basit metal kompleksleri sentezlenmiştir. Ayrıca trimesik asit, tereftalik asit, isoftalik asit, glutarik asit, 2,6-piridindikarboksilik asit, 4-hidroksi-2,6-piridindikarboksilik asit, krotonik asit, okzalik asit, pirazin-2-karboksilik asit, p-simen, sakarin, disiyanamit, N-salisiliden-2-hidroksianilin, asetoasetanilit, o-asetoasetotoluidit, o-asetoasetanisidit, dehidroasetik asit, 4,4’-bipiridin, bis-(salisilaldehit)fenilendiimin, N-(dehidroasetik asit)-tiyosemikarbazit, N-(dehidroasetik asit)-4-metil-3-tiyosemikarbazit, 4,5-dimetil-N,N-bis(piridin-2-yil-metilen)benzen-1,2-diimin, N-(dehidroasetik asit)-4- fenilsemikarbazit ve N-(dehidroasetik asit)-4-fenil-3-tiyosemikarbazit ile karışık ligandlı geçiş metal kompleksleri sentezlenmiş ve bazılarının biyolojik aktiviteleri incelenmiştir. 2-Aminobenzimidazol ve türevlerinden elde edilen proton transfer tuzu ve metal komplekslerinin de benzer biyolojik özellik gösterebileceği aşikardır.

Anahtar Kelimeler

2-Aminobenzimidazol, Metal kompleksi, Biyolojik aktivite

METAL COMPLEXES and BIOLOGICAL PROPERTIES of 2-AMINOBENZIMIDAZOLE

Öz

There are studies in the literature that 2-aminobenzimidazole and its derivatives have antibacterial, anticancer, antiviral, anti-inflammatory, antiproliferative, antifungal, anthelmintic and antihistamine properties. 2-Aminobenzimidazole and its derivatives are bonded to metal ions with one and two teeth due to three nitrogen atoms in their structure. Simple metal complexes of 2-aminobenzimidazole and its derivatives were synthesized. In addition, mixed ligand metal complexes of between 2-aminobenzimidazole and other ligands {trimesic acid, terephthalic acid, isophthalic acid, glutaric acid, 2,6-pyridinedicarboxylic acid, 4-hydroxy-2,6-pyridinedicarboxylic acid, crotonic acid, oxalic acid,pyrazine-2-carboxylic acid, p-cymene, saccharin, dicyanamide, N-salicylidene-2-hydroxyaniline, acetoacetanilide, o-acetoacetoluidide, o-acetoacetanisidide, dehydroacetic acid, N-(dehydroacetic acid)-4-methyl-3-thiosemicarbazide, 4,4'-bipyridine, bis-(salicylaldehyde)phenylenimine, N- (dehydroacetic acid)-thiosemicarbazide, 4,5-dimethyl-N,N-bis(pyridine-2-yl-methylene)benzene-1,2- diimine, N-(dehydroacetic acid)-4-phenylsemicarbazide and N-(dehydroacetic acid)-4-phenyl-3- thiosemicarbazide} were synthesized and the biological activities of some of them were investigated. It is obvious that proton transfer salt and metal complexes obtained from 2-aminobenzimidazole and its derivatives can also exhibit similar biological properties.

Anahtar Kelimeler

2-Aminobenzimidazole, Metal complex, Biological activity

Kaynakça

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