A CASE OF SEVERE PROTEINURIA DUE TO GLOMERULONEPHRITIS IN A CAT

Yıl 2024, , 1 - 6, 30.06.2024

Murat İlgün Sümeyye Baysal Emre Eren

https://doi.org/10.5281/zenodo.12571027

Öz

Glomerulonephritis is characterized by inflammation of the glomeruli. It is rare in cats and its etiology is not fully understood, although it can occur in many diseases such as feline leukemia virus (FeLV). Glomerulonephritis in cats presents with clinical signs such as proteinuria, hypoalbuminemia, ascites, among others. In this case presentation, detailed evaluation of glomerulonephritis was aimed in a 7-year-old neutered male tabby cat presenting with complaints of ascites, peripheral edema, loss of appetite, and weakness, and diagnosed based on clinical, laboratory and ultrasonography findings. Consequently, in cats exhibiting symptoms like proteinuria and ascites, glomerulonephritis should be thoroughly assessed.

Anahtar Kelimeler

Ascites, Glomerulonephritis, Cat, Proteinuria

Kaynakça

• 1. Grant DC, Forrester SD. Glomerulonephritis in dogs and cats: glomerular function, pathophysiology, and clinical signs. Compendium on Continuing Education for the Practising Veterinarian-North American Edition. 2001;23(8):739-747.
• 2. Syme HM, Markwell PJ, Pfeiffer DU, Elliott J. Survival of cats with naturally occurring chronic renal failure is related to severity of proteinuria. J. Vet. Intern. Med. 2006;20(3):528.
• 3. Kuwahar Y, Nishii N, Takasu M, Ohba Y, Maeda S, Kitagawa H. Use of urine albumin/creatinine ratio for estimation of proteinuria in cats and dogs. J Vet Med Sci. 2008;70(8): 865-867.
• 4. Rayhel LH, Quimby JM, Cianciolo RE, Cléroux A, McLeland S, Fränken T. Clinicopathologic and pathologic characteristics of feline proteinuric kidney disease. J Feline Med Surg. 2020;22(12):1219-1229.
• 5. Vaden SL. Glomerular disease. Top. Companion Anim. Med. 2011;26(3):128-134.
• 6. Cook AK, Cowgill LD. Clinical and pathological features of protein-losing glomerular disease in the dog: A review of 137 cases (1985–1992). J Am Anim Hosp Assoc. 1996;32:313–322.
• 7. Cianciolo RE, Mohr FC, Aresu L, et al. World small animal veterinary association renal pathology initiative: classification of glomerular diseases in dogs. Vet. Pathol. 2016;53(1):113-135.
• 8. Grauer GF, DiBartola SP. Glomerular disease, in Ettinger SJ, Feldman EC (eds): Textbook of Veterinary Internal Medicine. Diseases of the Dog and Cat. Philadelphia, WB Saunders Co, 2000; pp:1662–1678.
• 9. Gross C, Cianciolo RE, Lees GE, Brown CA, Foster JD. Proliferative, necrotizing and crescentic immune complex-mediated glomerulonephritis in a cat. J. Feline Med. Surg. Open Rep. 2015;1(2):2055116915603995.
• 10. Nash AS, Wright NG, Spencer AJ, Thompson H, Fisher EW. Membranous nephropathy in the cat: a clinical and pathological study. Vet. Rec. 1979;105(4):71-77.
• 11. Rossi F, Aresu L, Martini V, et al. Immune-complex glomerulonephritis in cats: a retrospective study based on clinico-pathological data, histopathology and ultrastructural features. BMC Vet. Res. 2019;15(1):1-9.
• 12. Thornburg LP, Kinden D, Digilio K. Immune glomerulitis in a cat. Vet. Pathol. 1979;16(5):604-606.
• 13. Reinacher M. Diseases associated with spontaneous feline leukemia virus (FeLV) infection in cats. Vet. Immunol. Immunopathol. 1989;21(1):85-95.
• 14. Arthur JE, Lucke VM, Newby TJ, Bourne FJ. The long-term prognosis of feline idiopathic membranous glomerulonephropathy. J Am Anim Hosp Assoc. 1986;22:731-737.
• 15. Lucke VM. Glomerulonephritis in the cat. Vet. Annu. 1982;22:270-278.
• 16. Asano T, Tsukamoto A, Ohno K, Ogihara K, Kamiie J, Shirota K. Membranoproliferative glomerulonephritis in a young cat. J Vet Med Sci. 2008;70(12):1373-1375.
• 17. Casado Bregón D, Cianciolo RE, Smith VA. The use of telmisartan in combination therapy in the management of nephrotic syndrome due to non‐immune‐mediated glomerulonephropathy in a young cat. Vet. Rec. Case Rep. 2021;9(4):e210.
• 18. Ranjbar R, Shafiee M, Hesari A, Ferns GA, Ghasemi F, Rezayi M. The potential therapeutic use of renin–angiotensin system inhibitors in the treatment of inflammatory diseases. J. Cell. Physiol. 2018;234(3):2277-2295.
• 19. Han W, Zhao H, Jiang B, Liu F. Epa and dha increased pparγ expression and deceased integrin-linked kinase and integrin β1 expression in rat glomerular mesangial cells treated with lipopolysaccharide. Biosci. Trends. 2014;8(2):120-125.
• 20. Hirahashi J, Hanafusa N, Wada T, et al. Aspirin and eicosapentaenoic acid may arrest progressive iga nephropathy: a potential alternative to immunosuppression. J. Intern. Med. 2015;54(18):2377-2382.
• 21. Buob S, Johnston AN, Webster CRL. Portal hypertension: pathophysiology, diagnosis, and treatment. J. Vet. Intern. Med. 2011;25(2):169-186.
• 22. Cavana P, Capucchio MT, Bovero A, et al. Noncongophilic fibrillary glomerulonephritis in a cat. Vet. Pathol. 2008;45(3):347-351.
• 23. Brown CA, Elliott J, Schmiedt CW, Brown SA. Chronic kidney disease in aged cats. Vet. Pathol. 2016;53(2):309-326.
• 24. Kuwahara Y, Ohba Y, Kitoh K, Kuwahara N, Kitagawa H. Association of laboratory data and death within one month in cats with chronic renal failure. J Small Anim Pract. 2006;47(8):446-450.
• 25. DeClue AE, Delgado C, Chang CH, Sharp CR. Clinical and immunologic assessment of sepsis and the systemic inflammatory response syndrome in cats. J Am Vet Med Assoc. 2011;238(7):890-897.
• 26. Muzumdar H. Pleural effusion. Pediatr Rev. 2012;33(1):45-47.
• 27. Bijsmans E, Jepson R, Chang Y, Syme HM, Elliott J. Changes in systolic blood pressure over time in healthy cats and cats with chronic kidney disease. J. Vet. Intern. Med. 2015;29(3):855-861.
• 28. Brown SA, Brown CA, Jacobs G, Stiles J, Hendi RS, Wilson S. Effects of the angiotensin converting enzyme inhibitor benazepril in cats with induced renal insufficiency. Am. J. Vet. Res. 2001;62(3):375-383.
• 29. Grant DC, Forrester SD. Glomerulonephritis in dogs and cats.Diagnosis and treatment. Compendium on Continuing Education for the Practising Veterinarian. 2011;23.
• 30. Brown CA, Jeong KS, Poppenga RH, et al. Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007. J. Vet. Diagn. Invest. 2007;19(5):525-531.