Histopathologic and Immunohistochemical Approach to a Case of Invasive Cribriform Carcinoma in Mammary Tissue of Sprague Dawley Rat
Yıl 2024,
, 11 - 13, 30.06.2024
Metin Kiliçlioğlu
,
Berrah Gözegir
,
İsmail Bolat
,
Yavuz Sağlam
,
Serkan Yıldırım
Öz
Breast cancer is a neoplastic disease that originates in the breast tissue and can metastasize to other tissues and organs, especially the lung and liver. It is one of the most common cancers in dogs and cats, especially in humans. Breast cancers exhibit striking genetic and phenotypic diversity and have a highly complex mechanism. There are many subtypes of mammary cancer with different biological and pathologic features and different clinical course. In this case report; the mass detected in the abdominal region of the rat was removed under general anesthesia. The mass was examined macroscopically, histopathologically and immunohistochemically. As a result of the examinations, mammary tissue . Invasive Cribriform Carcinoma was diagnosed. In immunohistochemical analysis, Ki67 and α-SMA expressions were detected in the mass. In this case report, we contributed to the literature by determining the histopathologic findings of Invasive Cribriform Carcinoma in mammary tissue of rats and the expression levels of Ki67 and α-SMA in these carcinomas.
Kaynakça
- 1. Cabadak H. Hücre siklusu ve kanser. ADÜ Tıp Fak Derg. 2018;9(3):51-61.
- 2. Quesenberry KE, Donnelly TM, Hillyer EV. Biology, husbandry, and clinical techniques of guinea pigs and chinchillas. In: Quesenberry KE, Carpenter JW (eds) Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 2nd edn, Elsevier/Saunders, St Louis. 2004: 232–327.
- 3. Davis RK, Stevenson GR, Busch KA. Tumor incidence in normal Sprague-Dawley female rats. Can Res. 1956;16:194-197.
- 4. Durbin PW, Williams MH, Jeung N, Arnold JS. Development of spontaneous mammary tumors over the life-span of the female Charles River (Sprague-Dawley) rat: The influence of ovariectomy, thyroidectomy and adrenalectomy-ovariectomy. Can Res. 1966;26:400-411.
- 5. Solleveld HA, Haseman JK, McConnell EE. Natural history of body weight gain, survival and neoplasia in the F344 rat. J Natl Can Inst. 1984;72:929-940.
- 6. Curtis MR, Bullock FD, Dunning WF. A statistical study of the occurrence of spontaneous tumors in a large colony of rats. Am J Can. 1931;15:67-121.
- 7. Wright AW, Klinck GHJ, Wolfe JM. The pathology and pathogenesis of mammary tumors occurring spontaneously in the Albany strain of rats. Am J Pathol. 1940;16:817-834.
- 8. Komitowski D, Sass B, Lamb W. Rat mammary tumor classification; Notes on comparative aspects. J Natl Can Inst. 1982;68:147-156.
- 9. Venable JG, Schwartz AM, Silverberg SG. Infiltrating cribriform carcinoma of the breast: a distinctive clinicopathologic entity. Hum. Pathol. 1990;21(3):333-338.
- 10. Buchsbaum RJ, Oh SY. Breast cancer-associated fibroblasts: where we are and where we need to go. Cancers. 2016;8(2):19.
- 11. Kadthur JC, Suguna Rao SR, Sonnahallipura BM, Thimmanahalli DS, Laxmikanth SM. Prognostic value of Ki 67 proliferation antigen in canine malignant mammary gland tumours. Braz. J Vet. Pathol. 2011:36-40.
Yıl 2024,
, 11 - 13, 30.06.2024
Metin Kiliçlioğlu
,
Berrah Gözegir
,
İsmail Bolat
,
Yavuz Sağlam
,
Serkan Yıldırım
Kaynakça
- 1. Cabadak H. Hücre siklusu ve kanser. ADÜ Tıp Fak Derg. 2018;9(3):51-61.
- 2. Quesenberry KE, Donnelly TM, Hillyer EV. Biology, husbandry, and clinical techniques of guinea pigs and chinchillas. In: Quesenberry KE, Carpenter JW (eds) Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 2nd edn, Elsevier/Saunders, St Louis. 2004: 232–327.
- 3. Davis RK, Stevenson GR, Busch KA. Tumor incidence in normal Sprague-Dawley female rats. Can Res. 1956;16:194-197.
- 4. Durbin PW, Williams MH, Jeung N, Arnold JS. Development of spontaneous mammary tumors over the life-span of the female Charles River (Sprague-Dawley) rat: The influence of ovariectomy, thyroidectomy and adrenalectomy-ovariectomy. Can Res. 1966;26:400-411.
- 5. Solleveld HA, Haseman JK, McConnell EE. Natural history of body weight gain, survival and neoplasia in the F344 rat. J Natl Can Inst. 1984;72:929-940.
- 6. Curtis MR, Bullock FD, Dunning WF. A statistical study of the occurrence of spontaneous tumors in a large colony of rats. Am J Can. 1931;15:67-121.
- 7. Wright AW, Klinck GHJ, Wolfe JM. The pathology and pathogenesis of mammary tumors occurring spontaneously in the Albany strain of rats. Am J Pathol. 1940;16:817-834.
- 8. Komitowski D, Sass B, Lamb W. Rat mammary tumor classification; Notes on comparative aspects. J Natl Can Inst. 1982;68:147-156.
- 9. Venable JG, Schwartz AM, Silverberg SG. Infiltrating cribriform carcinoma of the breast: a distinctive clinicopathologic entity. Hum. Pathol. 1990;21(3):333-338.
- 10. Buchsbaum RJ, Oh SY. Breast cancer-associated fibroblasts: where we are and where we need to go. Cancers. 2016;8(2):19.
- 11. Kadthur JC, Suguna Rao SR, Sonnahallipura BM, Thimmanahalli DS, Laxmikanth SM. Prognostic value of Ki 67 proliferation antigen in canine malignant mammary gland tumours. Braz. J Vet. Pathol. 2011:36-40.