Yıl 2019, Cilt 9 , Sayı 2, Sayfalar 323 - 334 2019-12-15

Bazı Yeni Antipirin Karbo (tiyo) amid ve 1,2,4-Triazol Türevlerinin Sentezi ve Anti-tuberküler Aktivitelerinin Karşılaştırılması
Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities

Hacer BAYRAK [1] , Yıldız UYGUN CEBECİ [2]


Bu çalışmada antipirin (4-Aminoantipirin) başlangıç maddesi olarak seçilerek karbotiyoamit ve 1,2,4-triazoltürevi bileşikler gerçekleştirilerek anti-tuberküler aktiviteleri karşılaştırılmıştır. 4-aminoantipirin sırasıyla etilbromoasetat, hidrazinhidrat ve çeşitli izo(tiyo)siyanatlar ile muamelesi sonucu bazik ortamda reaksiyonu ile halkalaşma reaksiyonu gerçekleşmesi ile yapıya ikinci bir halka olan 1,2,4-triazol halkasının ilavesi gerçekleştirildi. Sentezlenen yeni antipirin türevi bileşiklerin yapıları IR, NMR ve kütle spektrofotometresi gibi spektroskopik yöntemlerle aydınlatıldı. Sentezlenen yeni bileşikler, Gram olmayan bakteriye karşı aktivite çalışmaları gerçekleştirilmiştir. 

In this study, antipyrine (4-aminoantipyrine) was selected as the starting material and anti-tubercular activities were compared by carrying out the antipyrine nucleated carbothioamide and 1,2,4-triazole derivatives. The treatment of 4-aminoantipyrine with ethylbromoacetate, hydrazinhydrate and various iso (thio) cyanates, respectively, followed by cyclic reaction by basic reaction resulted in the addition of a second ring of 1,2,4-triazole to the structure. The structures of the synthesized new antipyrine derivatives were determined by spectroscopic methods such as IR, NMR and mass spectrophotometry. For the new compounds synthesized, activity studies were performed against non-Gram bacteria.
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Orcid: 0000-0001-5843-8716
Yazar: Hacer BAYRAK (Sorumlu Yazar)
Kurum: KARADENİZ TEKNİK ÜNİVERSİTESİ, MAÇKA MESLEK YÜKSEKOKULU
Ülke: Turkey


Orcid: 0000-0001-7949-0329
Yazar: Yıldız UYGUN CEBECİ
Kurum: KARADENİZ TEKNİK ÜNİVERSİTESİ
Ülke: Turkey


Destekleyen Kurum Karadeniz Teknik Üniversitesi Bilimsel Araştırma Projesi (KTÜ-BAP)
Proje Numarası 5289
Teşekkür This work was supported by the Scientific research project of Karadeniz Technical University (KTU-BAP) [grant numbers 5289]. The author also thanks to Prof. Şengül Alpay Karaoğlu for the antitubercular activity studies.
Tarihler

Yayımlanma Tarihi : 15 Aralık 2019

Bibtex @araştırma makalesi { kfbd620635, journal = {Karadeniz Fen Bilimleri Dergisi}, issn = {1309-4726}, eissn = {2564-7377}, address = {Giresun Üniversitesi Fen Bilimleri Enstitüsü Güre Yerleşkesi 28200 / Giresun}, publisher = {Giresun Üniversitesi}, year = {2019}, volume = {9}, pages = {323 - 334}, doi = {10.31466/kfbd.620635}, title = {Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities}, key = {cite}, author = {Bayrak, Hacer and Uygun Cebeci̇, Yıldız} }
APA Bayrak, H , Uygun Cebeci̇, Y . (2019). Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities . Karadeniz Fen Bilimleri Dergisi , 9 (2) , 323-334 . DOI: 10.31466/kfbd.620635
MLA Bayrak, H , Uygun Cebeci̇, Y . "Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities" . Karadeniz Fen Bilimleri Dergisi 9 (2019 ): 323-334 <https://dergipark.org.tr/tr/pub/kfbd/issue/50311/620635>
Chicago Bayrak, H , Uygun Cebeci̇, Y . "Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities". Karadeniz Fen Bilimleri Dergisi 9 (2019 ): 323-334
RIS TY - JOUR T1 - Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities AU - Hacer Bayrak , Yıldız Uygun Cebeci̇ Y1 - 2019 PY - 2019 N1 - doi: 10.31466/kfbd.620635 DO - 10.31466/kfbd.620635 T2 - Karadeniz Fen Bilimleri Dergisi JF - Journal JO - JOR SP - 323 EP - 334 VL - 9 IS - 2 SN - 1309-4726-2564-7377 M3 - doi: 10.31466/kfbd.620635 UR - https://doi.org/10.31466/kfbd.620635 Y2 - 2019 ER -
EndNote %0 Karadeniz Fen Bilimleri Dergisi Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities %A Hacer Bayrak , Yıldız Uygun Cebeci̇ %T Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities %D 2019 %J Karadeniz Fen Bilimleri Dergisi %P 1309-4726-2564-7377 %V 9 %N 2 %R doi: 10.31466/kfbd.620635 %U 10.31466/kfbd.620635
ISNAD Bayrak, Hacer , Uygun Cebeci̇, Yıldız . "Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities". Karadeniz Fen Bilimleri Dergisi 9 / 2 (Aralık 2019): 323-334 . https://doi.org/10.31466/kfbd.620635
AMA Bayrak H , Uygun Cebeci̇ Y . Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities. KFBD. 2019; 9(2): 323-334.
Vancouver Bayrak H , Uygun Cebeci̇ Y . Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities. Karadeniz Fen Bilimleri Dergisi. 2019; 9(2): 323-334.