Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities

Yıl 2019, Cilt: 9 Sayı: 2, 323 - 334, 15.12.2019

Hacer Bayrak Yıldız Uygun Cebeci

https://doi.org/10.31466/kfbd.620635

Öz

In this study, antipyrine (4-aminoantipyrine) was selected as the starting material and anti-tubercular activities were compared by carrying out the antipyrine nucleated carbothioamide and 1,2,4-triazole derivatives. The treatment of 4-aminoantipyrine with ethylbromoacetate, hydrazinhydrate and various iso (thio) cyanates, respectively, followed by cyclic reaction by basic reaction resulted in the addition of a second ring of 1,2,4-triazole to the structure. The structures of the synthesized new antipyrine derivatives were determined by spectroscopic methods such as IR, NMR and mass spectrophotometry. For the new compounds synthesized, activity studies were performed against non-Gram bacteria.

Anahtar Kelimeler

Antipyrine, 1 2 4-Triazole, Anti-tubercular Activity

Destekleyen Kurum

Karadeniz Teknik Üniversitesi Bilimsel Araştırma Projesi (KTÜ-BAP)

Proje Numarası

5289

Teşekkür

This work was supported by the Scientific research project of Karadeniz Technical University (KTU-BAP) [grant numbers 5289]. The author also thanks to Prof. Şengül Alpay Karaoğlu for the antitubercular activity studies.

Bazı Yeni Antipirin Karbo (tiyo) amid ve 1,2,4-Triazol Türevlerinin Sentezi ve Anti-tuberküler Aktivitelerinin Karşılaştırılması

Öz

Bu
çalışmada antipirin (4-Aminoantipirin) başlangıç maddesi olarak seçilerek
karbotiyoamit ve 1,2,4-triazoltürevi bileşikler gerçekleştirilerek anti-tuberküler
aktiviteleri karşılaştırılmıştır. 4-aminoantipirin sırasıyla etilbromoasetat,
hidrazinhidrat ve çeşitli izo(tiyo)siyanatlar ile muamelesi sonucu bazik
ortamda reaksiyonu ile halkalaşma reaksiyonu gerçekleşmesi ile yapıya ikinci
bir halka olan 1,2,4-triazol halkasının ilavesi gerçekleştirildi. Sentezlenen
yeni antipirin türevi bileşiklerin yapıları IR, NMR ve kütle spektrofotometresi
gibi spektroskopik yöntemlerle aydınlatıldı. Sentezlenen yeni bileşikler, Gram
olmayan bakteriye karşı aktivite çalışmaları gerçekleştirilmiştir. 

Anahtar Kelimeler

Antipirin, 1 2 4-Triazol, Anti-tuberküler Aktivite

Proje Numarası

5289

Kaynakça

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