Üre-Tiyoüre Temelli Şekerlerin Sentezi ve Enantiyoseçici Michael Katılmasında Organokatalitik Etkilerinin İncelenmesi

Yıl 2024, Cilt: 14 Sayı: 1, 38 - 49, 15.03.2024

Özer Işılar , Adnan Bulut

https://doi.org/10.31466/kfbd.1336183

Öz

Glukofuranoz amin ve galaktopiranoz aminden üre ve tiyoüre temelli yeni organokatalizörlerin (7-10) sentezi ve karakterizasyonu yapılmıştır. Bu bileşikler, farklı diketonlara trans-ß-nitrostiren’e enantiyoseçici Michael katılmasında organokatalizör olarak test edilmiştir. Sıcaklık, çözücü ve katkı maddeleri gibi parametreler ile yapılan optimizasyon sonucunda organokatalizörlerin %99 verim ve %11 enantiyomerik aşırılık ile katalizlediği tespit edilmiştir.

Anahtar Kelimeler

Enantiyoseçici sentez, Üre, Tiyoüre, Şeker, Organokatalizör

Destekleyen Kurum

Kırıkkale Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Proje Numarası

2017/060

Teşekkür

Bu çalışma Kırıkkale Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından 2017/060 numaralı araştırma projesiyle desteklenmiştir.

Synthesis of Urea-Thiourea Based Sugars and Investigation of Organocatalytic Effects in Enantioselective Michael Addition

Öz

Synthesis and characterization of urea and thiourea based novel organocatalysts (7-10) from glucofuranose amine and galactopyranose amine were obtained. These compounds were tested as organocatalyst for the enantioselective Michael addition of various diketones to trans-ß-nitrostyrene. As a result of optimization parameters such as temperature, solvent and additives, the organocatalysts were catalyzed with 99% yield and 11% enantiomeric excess.

Anahtar Kelimeler

Enantioselective synthesis, Urea, Thiourea, Sugar, Organocatalyst

Proje Numarası

2017/060

Kaynakça

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