How to Change Ceruloplasmin Levels in Heart Disease?

Yıl 2018, Cilt: 21 Sayı: 1, 61 - 64, 01.04.2018

Hatice Sezen Yusuf Sezen

Öz

Ceruloplasmin
(CP) is a blue serum protein found in human serum; it carries approximately 95%
of the total circulating copper (Cu) in healthy individuals. The relationship
of CP with OS, inflammation, and DNA damage is known. Oxidative stress (OS),
inflammation, and DNA damage are the main causes underlying atherosclerotic
heart disease. Several studies have indicated a close association between high
serum CP and several types of heart disease. However, the CP levels are still unknown
in many heart diseases. To gather the studies of CP in heart disease and to
prepare the ground for new studies for researchers, we designed this review.

Anahtar Kelimeler

Ceruloplasmin, oxidative stress, heart disease

Kalp Hastalıklarında Seruloplazmin Değerleri Nasıl Değişir?

Öz

Kanda
yaygın olarak bulunan ve mavi protein olarak adlandırılan seruloplazmin (CP)
sağlıklı kişilerde kanda bakırın %95’ini taşır. Oksidatif stres, inflamasyon ve
DNA hasarı ile ilişkisinin varlığı bilinmektedir. Oksidatif stres, inflamasyon
ve DNA hasarı, başta koroner arter hastalığı olmak üzere pek çok kalp hastalığı
etyolojisinde de suçlanmaktadır. Çok sayıda çalışma kalp hastalıklarında CP’nin
yerini ortaya koymuştur. Ancak çoğu kalp hastalığında halen CP seviyelerinin
nasıl değiştiği bilinmemektedir. Literatürdeki CP ile yapılmış kalp
hastalıklarındaki çalışmaları bir araya getirmek ve yapılacak yeni çalışmalara
zemin hazırlamak için bu derlemeyi yaptık.

Anahtar Kelimeler

Seruloplazmin, oksidatif stres, kalp hastalıkları

Kaynakça

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