ktd

Kocatepe Tıp Dergisi

3061-9904

Afyonkarahisar Sağlık Bilimleri Üniversitesi

10.18229/kocatepetip.1617128

Organic Chemical Synthesis

Organik Kimyasal Sentez

SÜBSTİTÜE BENZİMİDAZOL LİGANDLARI TAŞIYAN BAZI YENİ PLATİN (II) KOMPLEKSLERİNİN SENTEZİ VE ANTİKANSER AKTİVİTESİ

SYNTHESIS AND ANTICANCER ACTIVITY OF SOME NEW PLATINUM (II) COMPLEXES BEARING SUBSTITUTED BENZIMIDAZOLE LIGANDS

https://orcid.org/0000-0002-8783-6139

Akdağ

Mevlüt

Afyonkarahisar Sağlık Bilimleri Üniversitesi

https://orcid.org/0000-0002-9741-0641

Sarper

Meral

https://orcid.org/0000-0002-3160-5753

Özçelik

Azime Berna

GAZİ ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ

https://orcid.org/0000-0003-3181-9134

Utku

Semra

MERSİN ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ

04 16 2026

27 2 163 167 01 10 2025 05 27 2025

1999

Kocatepe Tıp Dergisi

AMAÇ: Platin bazlı bileşikler, çeşitli kanser türlerinin tedavisinde önemli terapötik ilaçlar olarak rol alırlar. Sisplatinin (cis-[Pt(NH3)2Cl2]) tedaviye sunulması platini ve diğer metalleri baz alan bileşiklerin kanser tedavisinde potansiyel tedaviler olarak kullanılmasında önemli bir gelişme olmuştur. Karboplatin ve oksaliplatin dünya çapında biliniyorken birkaç ilaç sadece belli bölgelerde onay almıştır. Yeni antikanser terapilerin geliştirilmesine acil ihtiyaç vardır çünkü mevcut ilaçların toksisitesi çok yüksektir ve bu da kullanımlarını kısıtlayan en önemli faktörlerden biridir. Bu çalışma antikanser aktiviteye sahip yeni platin kompleksleri bulmayı hedeflemektedir.GEREÇ VE YÖNTEM: Yeni platin türevlerinin geliştirilmesine yönelik bir strateji ayrılmayan grupların modifikasyonudur. Bu çalışmada 2-(2 or 4- triflorometil)fenil benzimidazol taşıyıcı ligandlarını içeren platin (II) kompleksleri sentezlenmiş ve MCF-7 hücrelerine karşı değerlendirilmiştir.BULGULAR: Sonuçlarımız kompleks 1 ve 2’nin MCF-7 hücrelerine karşı sırasıyla 141.57 μM ve 125.59 μM IC50 değeriyle inhibitör aktivite gösterdiğini ortaya koymuştur.SONUÇ: Bu kompleksler ileriki çalışmalar için lider bileşikler olarak değerlendirilebilir. Çeşitli modifikasyonlarla oluşturulan yeni serilerden in vitro aktivitesi daha yüksek ajanlar geliştirilebilir.

OBJECTIVE: Platinum-based compounds serve as crucial therapeutic remedies for treating various types of cancer. The introduction of cisplatin, or cis-[Pt(NH3)2Cl2], marked a significant breakthrough in harnessing platinum and other metal-based compounds as potential treatments for cancer. While carboplatin and oxaliplatin have secured global recognition, a few drugs have obtained approval in only specific regions. There is an urgent need of new anticancer therapies, since the available drugs are so toxic which is one of the main reasons restricting the application of these drugs. This study aims to find new platinum complexes endowed with anticancer activity.MATERIAL AND METHODS: One strategy to develop novel platinum derivatives involves modifying the non-leaving groups. In this research, platinum (II) complexes bearing 2-(2 or 4-trifloromethyl)phenyl benzimidazole carrier ligands were synthesized and evaluated against MCF-7 cells.RESULTS: Our results showed that complex 1 and 2 showed inhibitory activity against MCF-7 cells with IC50 values 141.57 μM and 125.59 μM respectively.CONCLUSIONS: These complexes can be evaluated as lead compounds for further studies. New series created with various modifications may yield agents with higher in vitro activity.

Platinum Synthesis Cancer Complex Pharmaceutical chemistry.

Platin Sentez Kanser Kompleks Farmasötik kimya.

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Compounds IC50 values (μM) Complex 1 141.57 Complex 2 125.59 Cis-platin 40.84

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