ktd Kocatepe Tıp Dergisi 3061-9904 Afyonkarahisar Sağlık Bilimleri Üniversitesi 10.18229/kocatepetip.522966 Clinical Sciences Klinik Tıp Bilimleri ANTİBİOTİC ASSOCİATED DRESS SYNDROME: A RARE CASE ANTİBİYOTİK İLİŞKİLİ DRESS SENDROMU:NADİR BİR OLGU https://orcid.org/0000-0001-8782-478X Kurt Alper Emre TIP FAKÜLTESİ https://orcid.org/0000-0002-5735-4200 Solakoğlu Tevfik AFYONKARAHİSAR SAĞLIK BİLİMLERİ ÜNİVERSİTESİ https://orcid.org/0000-0002-4632-9501 Araz Murat NECMETTİN ERBAKAN ÜNİVERSİTESİ, MERAM TIP FAKÜLTESİ 01 16 2020 21 1 59 63 02 06 2019 05 24 2019 Copyright © 1999, Kocatepe Tıp Dergisi 1999 Kocatepe Tıp Dergisi

DRESS (Drug Reaction with Eosinophilia and systemic symptoms) syndrome is thought to be a cause severe organ dysfunction syndrome. It is due to insufficient detoxification of drugs. When DRESS cases are screened, it is usually seen to be linked to antiepileptic drugs. Antibiotics can make DRESS syndrome even more rarely. We showed that with this case, DRESS may develop due to all drugs.

DRESS (Drug Reaction With Eosinophilia And Systemic Symptoms) sendromunun ciddi organ işlev bozukluklarına yol açan bir sendrom olduğu düşünülmektedir. İlaçların yetersiz detoksifikasyonuna bağlıdır. DRESS vakaları tarandığında genellikle antiepileptik ilaçlara bağlı olduğu görülmektedir. Antibiyotikler ise daha nadir de olsa DRESS sendromu yapabilir. Biz bu vaka ile tüm ilaçlara bağlı DRESS gelişebileceğini göstermek istedik.

 DRESS sendromu antibiyotik karaciğer yetmezliği DRESS Syndrome Antibiotic Liver Failure [1] S. L. Saltzstein and L. V. Ackerman, “Lymphadenopathy induced by anticonvulsant drugs and mimicking clinically and pathologically malignant lymphomas,” Cancer, vol. 12, no. 1, pp. 164–182, 1959. [2] P. Cacoub, P. Musette, V. Descamps et al., “The DRESS syndrome: A literature review,” American Journal of Medicine, vol. 124, no. 7. pp. 588–597, 2011. [3] S. Emre, G. Akoğlu, A. Metin, D. D. Demirseren, and G. Kurtoğlu, “DRESS sendromlu 11 olgunun klinik özelliklerinin incelenmesi,” Turkderm, vol. 47, no. 2, pp. 218–222, 2013. [4] V. Descamps and S. Ranger-Rogez, “DRESS syndrome,” Jt. Bone Spine, vol. 81, no. 1, pp. 15–21, 2014. [5] H. Bocquet, M. Bagot, and J. C. Roujeau, “Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS),” Seminars in Cutaneous Medicine and Surgery, vol. 15, no. 4. pp. 250–257, 1996. [6] I. A. Engell and G. Authried, “Drug reaction with eosinophilia and systemic symptoms (DRESS) induced by allopurinol: A case report,” Eur. Geriatr. Med., vol. 4, no. 2, pp. 99–101, 2013. [7] L. L. Oelze and M. T. Pillow, “Phenytoin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: A case report from the emergency department,” J. Emerg. Med., vol. 44, no. 1, pp. 75–78, 2013. [8] M. Ben m’rad, S. Leclerc-Mercier, P. Blanche et al., “Drug-induced hypersensitivity syndrome: clinical and biologic disease patterns in 24 patients.,” Medicine (Baltimore)., vol. 88, no. 3, pp. 131–140, 2009. [9] L. F. F. Botelho, V. S. Higashi, M. H. V. D. Q. Padilha, M. M. S. e S. Enokihara, and A. M. Porro, “DRESS: clinicopathological features of 10 cases from an University Hospital in São Paulo.,” An. Bras. Dermatol., vol. 87, no. 5, pp. 703–707, 2012. [10] Y.-C. Chen, H.-C. Chiu, and C.-Y. Chu, “Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases.,” Arch. Dermatol., vol. 146, no. 12, pp. 1373–9, 2010. [11] S. Yaylaci, M. V. Demir, T. Temiz, A. Tamer, and M. I. Uslan, “Allopurinol-induced DRESS syndrome.,” Indian J. Pharmacol., vol. 44, no. 3, pp. 412–414, May 2012. [12] E. A. Yilmaz, S. Özmen, N. Tuygun, T. Gİnİş, and G. Tanir, “Lamotrijin İlişkili Dress Sendromu : Bir Vaka Sunumu,” vol. 9, no. 3, pp. 142–146, 2009. [13] Y. CANITEZ, H. POYRAZ EFE, and N. SAPAN, “Carbamazepine-Related Dress Syndrome; A Rarely Seen Drug Hypersensitivity Reaction,” Turkish J. Pediatr. Dis., 2014. [14] R. Atalay, A. Demirezer Bolat, F. Ebru Ekın, T. Solakoğlu et al., “Karaciğer Enzim Yüksekliği ile Seyreden Dress Sendromu,” Türkiye Klin. …, vol. 19, no. 1, pp. 43–46, 2012. [15] P. L. Mpharm “Case Report Co-Trimoxazole-Induced DRESS Syndrome : A Case Report,” vol. 99, pp. 227–230, 2016. [16] Z. Ben-Ari, H. Vaknin, and R. Tur-Kaspa, “N-acetylcysteine in acute hepatic failure (non-paracetamol-induced).,” Hepatogastroenterology., vol. 47, no. 33, pp. 786–789, 2000.