The effect of selenium on cadmium-induced neurotoxicity model in rats: The role of TRPM2 cation channel

Hamza Avci; Kenan Yıldızhan

doi:10.66235/kumj.1887610

The effect of selenium on cadmium-induced neurotoxicity model in rats: The role of TRPM2 cation channel

Abstract

Aims: Neurotoxicity is characterized by structural and functional neuronal disorders resulting from exposure to toxic substances in the central and peripheral nervous systems. Cadmium (Cd), a toxic heavy metal with widespread industrial uses, is known to have significant neurotoxic effects on the nervous system. This study investigated the protective effect of selenium (Se) against CdCl₂-induced neurotoxicity in rat brain tissue and evaluated the possible involvement of the Transient Receptor Potential Melastatin-2 (TRPM2) channel in this process.

Methods: In the study, 40 male Wistar Albino rats were randomly divided into five groups (n=8): Control, CdCl₂, CdCl₂+Se, CdCl₂+2-APB, and CdCl₂+Se+2-APB. For five days, CdCl₂ (25 mg/kg) was administered intragastrically, and Se (0.5 mg/kg) and the TRPM2 inhibitor 2-Aminoethoxydiphenyl Borate (2-APB; 3 mg/kg) were administered intraperitoneally.

Results: Total antioxidant levels (TAS), total oxidant levels (TOS), reactive oxygen species (ROS), poly (ADP-ribose) polymerase-1 (PARP-1), and TRPM2 levels in brain tissues were analyzed using "ELISA kits". In the CdCl₂ group, TOS, ROS, PARP-1, and TRPM2 levels were significantly increased compared to the control group, while TAS levels were significantly decreased (p<0.05). Se and 2-APB administrations significantly reversed these changes; the most significant improvement was observed in the CdCl₂+Se+2-APB group (p<0.05).

Conclusion: The present findings suggest that CdCl₂ exposure is associated with increased oxidative stress-related markers and TRPM2 levels in rat brain tissue, whereas Se and 2-APB treatment partially attenuate these alterations.

Keywords

Supporting Institution

Van Yuzuncu Yil University Scientific Research Projects (BAP)

Project Number

TYL-2024-11059

Ethical Statement

Van Yüzüncü Yıl University Local Ethics Committee for Animal Experiments (decision no: 2023/14-11, date: 28.12.2023).

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Details

Primary Language

English

Subjects

Neurosciences (Other)

Journal Section

Research Article

Authors

Hamza Avci
0009-0006-2580-9035
Türkiye

Kenan Yıldızhan ^*
0000-0002-6585-4010
Türkiye

Publication Date

June 16, 2026

Submission Date

February 12, 2026

Acceptance Date

April 23, 2026

Published in Issue

Year 2026 Volume: 6 Number: 2

DOI

https://doi.org/10.66235/kumj.1887610

IZ

https://izlik.org/JA54ML42TD

Cite

RIS / Bibtex

APA

Avci, H., & Yıldızhan, K. (2026). The effect of selenium on cadmium-induced neurotoxicity model in rats: The role of TRPM2 cation channel. Kastamonu Medical Journal, 6(2), 169-175. https://doi.org/10.66235/kumj.1887610

AMA

1.Avci H, Yıldızhan K. The effect of selenium on cadmium-induced neurotoxicity model in rats: The role of TRPM2 cation channel. Kastamonu Medical Journal. 2026;6(2):169-175. doi:10.66235/kumj.1887610

Chicago

Avci, Hamza, and Kenan Yıldızhan. 2026. “The Effect of Selenium on Cadmium-Induced Neurotoxicity Model in Rats: The Role of TRPM2 Cation Channel”. Kastamonu Medical Journal 6 (2): 169-75. https://doi.org/10.66235/kumj.1887610.

EndNote

Avci H, Yıldızhan K (June 1, 2026) The effect of selenium on cadmium-induced neurotoxicity model in rats: The role of TRPM2 cation channel. Kastamonu Medical Journal 6 2 169–175.

IEEE

[1]H. Avci and K. Yıldızhan, “The effect of selenium on cadmium-induced neurotoxicity model in rats: The role of TRPM2 cation channel”, Kastamonu Medical Journal, vol. 6, no. 2, pp. 169–175, June 2026, doi: 10.66235/kumj.1887610.

ISNAD

Avci, Hamza - Yıldızhan, Kenan. “The Effect of Selenium on Cadmium-Induced Neurotoxicity Model in Rats: The Role of TRPM2 Cation Channel”. Kastamonu Medical Journal 6/2 (June 1, 2026): 169-175. https://doi.org/10.66235/kumj.1887610.

JAMA

1.Avci H, Yıldızhan K. The effect of selenium on cadmium-induced neurotoxicity model in rats: The role of TRPM2 cation channel. Kastamonu Medical Journal. 2026;6:169–175.

MLA

Avci, Hamza, and Kenan Yıldızhan. “The Effect of Selenium on Cadmium-Induced Neurotoxicity Model in Rats: The Role of TRPM2 Cation Channel”. Kastamonu Medical Journal, vol. 6, no. 2, June 2026, pp. 169-75, doi:10.66235/kumj.1887610.

Vancouver

1.Hamza Avci, Kenan Yıldızhan. The effect of selenium on cadmium-induced neurotoxicity model in rats: The role of TRPM2 cation channel. Kastamonu Medical Journal. 2026 Jun. 1;6(2):169-75. doi:10.66235/kumj.1887610