kırıkkale üni tıp derg The Journal of Kırıkkale University Faculty of Medicine 2148-9645 Kırıkkale Üniversitesi 10.24938/kutfd.1775040 Health Services and Systems (Other) Sağlık Hizmetleri ve Sistemleri (Diğer) 1–6 Yaş Arası Çocuklarda Akut Gastroenterit Nedeniyle Oral Ondansetron Kullanımının Yeniden Başvuru ve Hastane Yatışlarına Etkisi: Retrospektif Kohort Çalışması EFFECTIVENESS OF ORAL ONDANSETRON ON REVISITS AND HOSPITAL ADMISSIONS IN CHILDREN AGED 1–6 YEARS WITH ACUTE GASTROENTERITIİS: A RETROSPECTIVE COHORT STUDY https://orcid.org/0000-0002-5357-9015 Çelik Aydın Department of Pediatrics, Al Sadd Health Center, Primary Health Care Corporation (PHCC), Doha, Qatar https://orcid.org/0000-0002-5739-6902 Tuluce Mahmut Esat Department of Pediatrics, Umm Salal Health Center, Primary Health Care Corporation (PHCC), Doha, Qatar https://orcid.org/0009-0007-3995-6121 Celebi Nihat Cem Department of Pediatrics, Acıbadem Maslak Hospital, Istanbul, Türkiye 04 27 2026 28 1 44 48 09 01 2025 01 12 2026 Copyright © 1999, Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 1999 Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

Amaç: Akut gastroenterit, özellikle çocukluk çağında dünya genelinde önemli bir halk sağlığı sorunu olmaya devam etmektedir ve sağlık sistemleri üzerinde klinik ve ekonomik bir yük oluşturmaktadır. Ondansetron, seçici bir serotonin 5-HT3 reseptör antagonisti olup başlangıçta kemoterapiye bağlı bulantı ve kusmanın önlenmesi amacıyla geliştirilmiştir. Son yıllarda, oral ondansetronun çocuklarda akut gastroenterit semptomlarının kontrolünde kullanılabileceğine dair çalışmalar mevcuttur. Bu çalışmanın amacı, 1–6 yaş arası akut gastroenteritli çocuklarda oral ondansetron kullanımının acil servise yeniden başvuru ve hastaneye yatış oranları ile ilişkisini değerlendirmektir.Gereç ve Yöntemler: Bu retrospektif kohort çalışması, Ocak 2022–Kasım 2024 tarihleri arasında Acıbadem Maslak Hastanesi Çocuk Acil Servisi’ne akut gastroenterit bulguları ile başvuran 339 hastayı kapsamaktadır. Hastalar, oral ondansetron tedavisi alan (n=162) ve antiemetik tedavi almayan kontrol grubu (n=177) olmak üzere iki gruba ayrılmıştır. Demografik ve klinik veriler elektronik hasta kayıtlarından elde edilmiştir. Acil servise yeniden başvuru, hastaneye yatış ve intravenöz sıvı gereksinimi oranları karşılaştırılmıştır.Bulgular: Oral ondansetron uygulanan grupta acil servise yedi gün içinde yeniden başvuru oranı %14 iken, kontrol grubunda bu oran %21 olarak saptanmıştır (p=0,036). Hastaneye yatış oranı ondansetron grubunda %2, kontrol grubunda %10 olarak bulunmuştur (p

Objective: Acute gastroenteritis remains an important public health problem worldwide, particularly in childhood, and continues to impose a clinical and economic burden on healthcare systems. Ondansetron is a selective serotonin 5-HT3 receptor antagonist that was initially developed for the prevention of chemotherapy-induced nausea and vomiting. In recent years, oral ondansetron has been increasingly used in children with acute gastroenteritis. The aim of this study was to evaluate the association between oral ondansetron use and emergency department revisit and hospital admission rates in children aged 1–6 years with acute gastroenteritis.Material and Methods:This retrospective cohort study included 339 children aged 1–6 years who presented with symptoms of acute gastroenteritis to the Pediatric Emergency Department of Acibadem Maslak Hospital between January 2022 and November 2024. Patients were divided into two groups: those who received oral ondansetron (n=162) and those who did not receive any antiemetic treatment (control group, n=177). Demographic and clinical data were obtained from electronic medical records. Rates of emergency department revisits, hospital admissions, and intravenous fluid requirement were compared between the groups.Results:The rate of emergency department revisit within 7 days was 14% in the ondansetron group and 21% in the control group (p=0.036). Hospital admission rates were lower in the ondansetron group compared with the control group (2% vs. 10%, p

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