Research Article
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Year 2023, , 286 - 292, 31.12.2023
https://doi.org/10.24998/maeusabed.1347224

Abstract

Supporting Institution

Burdur Mehmet Akif Ersoy University Scientific Research Projects Commission- Burdur Mehmet Akif Ersoy Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü

Project Number

0762-YL-21

Thanks

Bu projenin desteklenmesi için Burdur Mehmet Akif Ersoy Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğüne Teşekkür Ederiz.

References

  • Appleton, D.J., Rand, J.S., & Sunvold, G.D., 2000. Plasma leptin concentrations in cats: reference range, effect of weight gain and relationship with adiposity as measuredby dual energy X-ray absorptiometry. Journal of Feline Medicine and Surgery 2, 191–199.
  • Auwerx, J., Staels, B., 1998. Leptin. Lancet 351, 737-742.
  • Backus, R.C., Havel, P.J., Gingerich, R.L., Rogers, Q.R., 2000. Relationship between serum leptin immunoreactivity and body fat mass as estimated by use of a novel gasphase Fourier transform infrared spectroscopy deuterium dilution method in cats. American Journal of Veterinary Research 61, 796–801.
  • Bang, A.S., Soule, S.G., Yandle, T.G., Mark Richards, A., Pemberton, C.J., 2007. Characterisation of proghrelin peptides in mammalian tissue and plasma. Journal of Endocrinology 192, 313-323.
  • Belotta, A.F.,Teixeira, C.R., Padovani, C.R., Rahal, S.C., Mayer, M.N., Mamprim, M.J., 2018. Sonographic evaluation of liver hemodynamic indices in overweight and obese dogs. Journal of Veterinary Internal Medicine 32, 181-187.
  • Crandall, D.L., Hausman, G.J., Kral, J.G., 1997. A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation 4, 211-232.
  • Engelmann, G., Hoffmann, G.F., Grulich-Henn, J., Teufel, U., 2014. Alanine aminotransferase elevation in obese infants and children: a marker of early onset non alcoholic fatty liver disease 14, 4.
  • Fried, S.K., Ricci, M.R., Russell, C.D., Laferrère, B., 2000. Regulation of Leptin Production in Humans. The Journal of Nutrition 130, 3127–3131.
  • Friedman, J.M., Halaas, J.L., 1998. Leptin and the regulation of body weight in mammals. Nature 395, 763-770.
  • German, A.J., 2006. The growing problem of obesity in dogs and cats. The Journal of Nutrition 136, 1940-1946.
  • Hamoui, N., Anthone, G., Crookes, P.F., 2004. Calcium metabolism in the morbidly obese. Obesity Surgery 14, 9-12.
  • Hoelmkjaer, K.M., Bjornvad, C.R., 2014. Management of obesity in cats. Veterinary medicine (Auckland, N.Z.) 5, 97-107.
  • Hoenig, M., Pach, N.,Thomaseth, K., DeVries, F., Ferguson, D.C., 2012. Evaluation of long-term glucose homeostasis in lean and obese cats by use of continuous glucose monitoring. American Journal of Veterinary Research 73, 7.
  • Hoenig, M., Thomaseth, K., Waldron, M., Ferguson, D.C., 2007. Insulin sensitivity,fat distribution, and adipocytokine response to different diets in lean and obese catsbefore and after weight loss. The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 292, 227–234.
  • Ikezaki, A., Hosoda, H., Ito, K., Iwama, S., Miura, N., Matsuoka, H., Kondo, C., Kojima, M., Kangawa, K., Sugihara, S., 2002. Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes 51, 3408-3411.
  • İlhan ,T., Erdost, H., 2009. Ghrelin. Uludag University Journal of the Faculty of Veterinary Medicine 28, 67-74.
  • Karima, Q.M., Kuroda, S., Izawa, T., Maeda, Y., Sato, M., Watanabe, K., Horiuchi, S., Tanaka, E., 2016. The Effectiveness of Human Parathyroid Hormone and Low-Intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones. Annals of Biomedical Engineering 44 ( 8), 2480–2488.
  • Kaya, F., Bozkurt, G., 2022. Metabolic evaluation on Sakiz ewes with still and live births without etiological diagnosis. Veterinary Journal of Mehmet Akif Ersoy University 7(1), 51-57.
  • Kojima, M., Kangawa, K., 2005. Ghrelin: structure and function, Physiological Reviews 85, 2, 495- 522.
  • Man, E., Cheung, P., Cheung, Y., 2017. Associations between arterial structure and function and serum levels of liver enzymes in obese adolescents. Journal of Paediatrics and Child Health 53, 691-697.
  • Martin, L.JM., Siliart, B., Lutz, T.A., Biourge, V., Nguyen, P., Dumon, H.J.W., 2010. Postprandial response of plasma insulin, amylin and acylated ghrelin to various test meals in lean and obese cats. British Journal of Nutrition 103, 1610–1619.
  • Montague, C.T., Farooqi, I.S., Whitehead, J.P., Soos, M.A., Rau, H., Wareham, N.J., Sewte,r C.P., Digby, J.E., Mohammed, S.N., Hurst, J.A., Cheetham, C.H., Earley, A.R.,Barnett, A.H., Prins, J.B., O'Rahilly, S., 1997. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903-908.
  • Moura, de Lima C., Boff, G.A., Pereira, S.B., Ferraz, A., Bruhn, F.R.P., Rondelli, M.C.H., Nobre, M.O., 2021. Feline obesity: risk factors and clinical and metabolic findings. Semina: Ciênc. Agrár. Londrina 42, 6, 3305-3320.
  • Müller, T.D., Nogueiras, R., Andermann, M.L., Andrews, Z.B., Anker, S.D., Argente, J., Batterham, R.L., Benoit, S.C., Bowers, C.Y., Broglio, F., Casanueva, F.F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P.A., Cowley, M., Cummings, D.E., Dagher, A., Diano, S., Dickson, S.L., Diéguez, C., Granata, R., Grill, H.J., Grove, K., Habegger, K.M., Heppner, K., Heiman, M.L., Holsen, L., Holst, B., Inui, A., Jansson, J.O., Kirchner, H., Korbonits, M., Laferrère, B., LeRoux, C.W., Lopez, M., Morin, S.,Nakazato, M., Nass, R., Perez-Tilve, D., Pfluger, P.T., Schwartz, T.W., Seeley, R.J., Sleeman, M., Sun, Y., Sussel, L., Tong, J., Thorner, M.O., van der Lely, A.J., van derPloeg, L.H.T., Zigman, J.M., Kojima, M., Kangawa, K., Smith, R.G., Horvath, T., Tschöp, M.H., 2015. Ghrelin: Molecular Metabolism, Minireview 437-460.
  • Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A.J., Gojobori, T., Isenovic, E.R., 2021. Leptin and obesity: role and clinical implication. Frontiers in Endocrinology 12.
  • Opitz, M., 1990. Stress hyperglycemia in cats. Berl Munch Tierarztl Wochenschr 103, 151–158.
  • Öztürk, A.S., Arpacı, A., 2018. Obezite ve ghrelin/leptin ilişkisi. Mustafa Kemal Üniversitesi Tıp Dergis 9, 136-151.
  • Shah, P., Chauhan, A.P., 2016. Impact of obesity on vitamin D and calcium status. International Journal of Medical Research and Review 4, 275-280.
  • Speakman, J.R., 2004. Obesity: the integrated roles of environment and genetics. The Journal of Nutrition 134, 2090-2105.
  • Tschop, M., Weyer, C., Tataranni, P.A., Devanarayan, V., Ravussin, E., Heiman, M.L., 2001. Circulating ghrelin levels are decreased in human obesity. Diabetes 50, 707- 709.
  • Wallace, A.M., 2000. Measurement of leptin and leptin binding in the human circulation. Annals of Clinical Biochemistry 37, 244-252.
  • Yalcin, E., Yilmaz, Z., Ozarda, Y., 2017. Serum leptin and ghrelin levels and their relationship with serum cortisol, thyroid hormones, lipids, homocysteine and folic acid in dogs with compulsive tail chasing. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 23 (2): 227-232.
  • Zoran, D.L., 2019. Feline obesity: clinical recognition and management. Compendium Continuing Education For Veterinarians 31, 284-293.

Investigation of ghrelin and leptin value in obese and non-Obese cats

Year 2023, , 286 - 292, 31.12.2023
https://doi.org/10.24998/maeusabed.1347224

Abstract

Obesity is the deterioration of metabolic and physiological functions due to excessive accumulation of fat in the body. The main medical concern of obesity, an increasingly common problem in domestic cats, is that it is associated with many diseases that accompany abnormal fat deposition. Leptin and ghrelin are two hormones involved in energy balance. Ghrelin is an orexigenic hormone while leptin is an anorexigenic hormone. There is still not enough information about these two hormones and there is very little research investigating their connection with obesity. The animal material of this study consists of cats of different breeds, ages and genders, which were brought to clinically healthy routine controls and were healthy according to the results of physical examination, hemogram and blood biochemistry. In this study, 20 cats were evaluated with the body fat measurement system in cats. Those with body fat ratio above 30% were considered obese (n=10), those below 30% were considered as the control group (n=10). Leptin and ghrelin values were measured by ELISA method and their relations with each other were evaluated. Serum leptin (p=0.05) and ghrelin (p=0.001) values were determined in cats in both groups, and statistically significant differences were observed. As a result, it was determined that leptin and ghrelin hormones play an important role in obese cats and are related to each other.

Project Number

0762-YL-21

References

  • Appleton, D.J., Rand, J.S., & Sunvold, G.D., 2000. Plasma leptin concentrations in cats: reference range, effect of weight gain and relationship with adiposity as measuredby dual energy X-ray absorptiometry. Journal of Feline Medicine and Surgery 2, 191–199.
  • Auwerx, J., Staels, B., 1998. Leptin. Lancet 351, 737-742.
  • Backus, R.C., Havel, P.J., Gingerich, R.L., Rogers, Q.R., 2000. Relationship between serum leptin immunoreactivity and body fat mass as estimated by use of a novel gasphase Fourier transform infrared spectroscopy deuterium dilution method in cats. American Journal of Veterinary Research 61, 796–801.
  • Bang, A.S., Soule, S.G., Yandle, T.G., Mark Richards, A., Pemberton, C.J., 2007. Characterisation of proghrelin peptides in mammalian tissue and plasma. Journal of Endocrinology 192, 313-323.
  • Belotta, A.F.,Teixeira, C.R., Padovani, C.R., Rahal, S.C., Mayer, M.N., Mamprim, M.J., 2018. Sonographic evaluation of liver hemodynamic indices in overweight and obese dogs. Journal of Veterinary Internal Medicine 32, 181-187.
  • Crandall, D.L., Hausman, G.J., Kral, J.G., 1997. A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation 4, 211-232.
  • Engelmann, G., Hoffmann, G.F., Grulich-Henn, J., Teufel, U., 2014. Alanine aminotransferase elevation in obese infants and children: a marker of early onset non alcoholic fatty liver disease 14, 4.
  • Fried, S.K., Ricci, M.R., Russell, C.D., Laferrère, B., 2000. Regulation of Leptin Production in Humans. The Journal of Nutrition 130, 3127–3131.
  • Friedman, J.M., Halaas, J.L., 1998. Leptin and the regulation of body weight in mammals. Nature 395, 763-770.
  • German, A.J., 2006. The growing problem of obesity in dogs and cats. The Journal of Nutrition 136, 1940-1946.
  • Hamoui, N., Anthone, G., Crookes, P.F., 2004. Calcium metabolism in the morbidly obese. Obesity Surgery 14, 9-12.
  • Hoelmkjaer, K.M., Bjornvad, C.R., 2014. Management of obesity in cats. Veterinary medicine (Auckland, N.Z.) 5, 97-107.
  • Hoenig, M., Pach, N.,Thomaseth, K., DeVries, F., Ferguson, D.C., 2012. Evaluation of long-term glucose homeostasis in lean and obese cats by use of continuous glucose monitoring. American Journal of Veterinary Research 73, 7.
  • Hoenig, M., Thomaseth, K., Waldron, M., Ferguson, D.C., 2007. Insulin sensitivity,fat distribution, and adipocytokine response to different diets in lean and obese catsbefore and after weight loss. The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 292, 227–234.
  • Ikezaki, A., Hosoda, H., Ito, K., Iwama, S., Miura, N., Matsuoka, H., Kondo, C., Kojima, M., Kangawa, K., Sugihara, S., 2002. Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes 51, 3408-3411.
  • İlhan ,T., Erdost, H., 2009. Ghrelin. Uludag University Journal of the Faculty of Veterinary Medicine 28, 67-74.
  • Karima, Q.M., Kuroda, S., Izawa, T., Maeda, Y., Sato, M., Watanabe, K., Horiuchi, S., Tanaka, E., 2016. The Effectiveness of Human Parathyroid Hormone and Low-Intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones. Annals of Biomedical Engineering 44 ( 8), 2480–2488.
  • Kaya, F., Bozkurt, G., 2022. Metabolic evaluation on Sakiz ewes with still and live births without etiological diagnosis. Veterinary Journal of Mehmet Akif Ersoy University 7(1), 51-57.
  • Kojima, M., Kangawa, K., 2005. Ghrelin: structure and function, Physiological Reviews 85, 2, 495- 522.
  • Man, E., Cheung, P., Cheung, Y., 2017. Associations between arterial structure and function and serum levels of liver enzymes in obese adolescents. Journal of Paediatrics and Child Health 53, 691-697.
  • Martin, L.JM., Siliart, B., Lutz, T.A., Biourge, V., Nguyen, P., Dumon, H.J.W., 2010. Postprandial response of plasma insulin, amylin and acylated ghrelin to various test meals in lean and obese cats. British Journal of Nutrition 103, 1610–1619.
  • Montague, C.T., Farooqi, I.S., Whitehead, J.P., Soos, M.A., Rau, H., Wareham, N.J., Sewte,r C.P., Digby, J.E., Mohammed, S.N., Hurst, J.A., Cheetham, C.H., Earley, A.R.,Barnett, A.H., Prins, J.B., O'Rahilly, S., 1997. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903-908.
  • Moura, de Lima C., Boff, G.A., Pereira, S.B., Ferraz, A., Bruhn, F.R.P., Rondelli, M.C.H., Nobre, M.O., 2021. Feline obesity: risk factors and clinical and metabolic findings. Semina: Ciênc. Agrár. Londrina 42, 6, 3305-3320.
  • Müller, T.D., Nogueiras, R., Andermann, M.L., Andrews, Z.B., Anker, S.D., Argente, J., Batterham, R.L., Benoit, S.C., Bowers, C.Y., Broglio, F., Casanueva, F.F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P.A., Cowley, M., Cummings, D.E., Dagher, A., Diano, S., Dickson, S.L., Diéguez, C., Granata, R., Grill, H.J., Grove, K., Habegger, K.M., Heppner, K., Heiman, M.L., Holsen, L., Holst, B., Inui, A., Jansson, J.O., Kirchner, H., Korbonits, M., Laferrère, B., LeRoux, C.W., Lopez, M., Morin, S.,Nakazato, M., Nass, R., Perez-Tilve, D., Pfluger, P.T., Schwartz, T.W., Seeley, R.J., Sleeman, M., Sun, Y., Sussel, L., Tong, J., Thorner, M.O., van der Lely, A.J., van derPloeg, L.H.T., Zigman, J.M., Kojima, M., Kangawa, K., Smith, R.G., Horvath, T., Tschöp, M.H., 2015. Ghrelin: Molecular Metabolism, Minireview 437-460.
  • Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A.J., Gojobori, T., Isenovic, E.R., 2021. Leptin and obesity: role and clinical implication. Frontiers in Endocrinology 12.
  • Opitz, M., 1990. Stress hyperglycemia in cats. Berl Munch Tierarztl Wochenschr 103, 151–158.
  • Öztürk, A.S., Arpacı, A., 2018. Obezite ve ghrelin/leptin ilişkisi. Mustafa Kemal Üniversitesi Tıp Dergis 9, 136-151.
  • Shah, P., Chauhan, A.P., 2016. Impact of obesity on vitamin D and calcium status. International Journal of Medical Research and Review 4, 275-280.
  • Speakman, J.R., 2004. Obesity: the integrated roles of environment and genetics. The Journal of Nutrition 134, 2090-2105.
  • Tschop, M., Weyer, C., Tataranni, P.A., Devanarayan, V., Ravussin, E., Heiman, M.L., 2001. Circulating ghrelin levels are decreased in human obesity. Diabetes 50, 707- 709.
  • Wallace, A.M., 2000. Measurement of leptin and leptin binding in the human circulation. Annals of Clinical Biochemistry 37, 244-252.
  • Yalcin, E., Yilmaz, Z., Ozarda, Y., 2017. Serum leptin and ghrelin levels and their relationship with serum cortisol, thyroid hormones, lipids, homocysteine and folic acid in dogs with compulsive tail chasing. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 23 (2): 227-232.
  • Zoran, D.L., 2019. Feline obesity: clinical recognition and management. Compendium Continuing Education For Veterinarians 31, 284-293.
There are 33 citations in total.

Details

Primary Language English
Subjects Veterinary Sciences (Other)
Journal Section Research Article
Authors

Şefika Akgün 0009-0002-8615-1020

Şima Şahinduran 0000-0002-7718-2020

Project Number 0762-YL-21
Early Pub Date December 20, 2023
Publication Date December 31, 2023
Submission Date August 21, 2023
Published in Issue Year 2023

Cite

APA Akgün, Ş., & Şahinduran, Ş. (2023). Investigation of ghrelin and leptin value in obese and non-Obese cats. Mehmet Akif Ersoy University Journal of Health Sciences Institute, 11(3), 286-292. https://doi.org/10.24998/maeusabed.1347224
AMA Akgün Ş, Şahinduran Ş. Investigation of ghrelin and leptin value in obese and non-Obese cats. Mehmet Akif Ersoy University Journal of Health Sciences Institute. December 2023;11(3):286-292. doi:10.24998/maeusabed.1347224
Chicago Akgün, Şefika, and Şima Şahinduran. “Investigation of Ghrelin and Leptin Value in Obese and Non-Obese Cats”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 11, no. 3 (December 2023): 286-92. https://doi.org/10.24998/maeusabed.1347224.
EndNote Akgün Ş, Şahinduran Ş (December 1, 2023) Investigation of ghrelin and leptin value in obese and non-Obese cats. Mehmet Akif Ersoy University Journal of Health Sciences Institute 11 3 286–292.
IEEE Ş. Akgün and Ş. Şahinduran, “Investigation of ghrelin and leptin value in obese and non-Obese cats”, Mehmet Akif Ersoy University Journal of Health Sciences Institute, vol. 11, no. 3, pp. 286–292, 2023, doi: 10.24998/maeusabed.1347224.
ISNAD Akgün, Şefika - Şahinduran, Şima. “Investigation of Ghrelin and Leptin Value in Obese and Non-Obese Cats”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 11/3 (December 2023), 286-292. https://doi.org/10.24998/maeusabed.1347224.
JAMA Akgün Ş, Şahinduran Ş. Investigation of ghrelin and leptin value in obese and non-Obese cats. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2023;11:286–292.
MLA Akgün, Şefika and Şima Şahinduran. “Investigation of Ghrelin and Leptin Value in Obese and Non-Obese Cats”. Mehmet Akif Ersoy University Journal of Health Sciences Institute, vol. 11, no. 3, 2023, pp. 286-92, doi:10.24998/maeusabed.1347224.
Vancouver Akgün Ş, Şahinduran Ş. Investigation of ghrelin and leptin value in obese and non-Obese cats. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2023;11(3):286-92.