Sepsisli Neonatal Buzağılarda Bazı Hematolojik ve Biyokimyasal Parametrelerin Araştırılması

Abstract

Öz: Çalışmanın amacı sepsisli neonatal buzağılarda hematolojik ve biyokimyasal değişimlerin araştırılmasıdır. Çalışmada, 20 adet sepsisli ve klinik olarak sağlıklı 10 adet neonatal buzağı kullanıldı. Bütün buzağıların rutin klinik muayenesi yapıldı ve monitörize edilerek sistolik kan basıncı (SKB), diyastolik kan basıncı (DKB) ve ortalama arteriyel kan basıncı (MAP) belirlendi. Ayrıca tüm hayvanların pulse oksimetre ile oksijen satürasyonları (SpO₂) ölçüldü. Çalışmada yer alan tüm buzağıların hematolojik ve biyokimyasal analizleri yapıldı. Çalışmada sepsisli buzağıların vücut ısısı (p<0.001) ve SpO₂ (p<0.01) değerleri düşük, solunum sayılarının (p<0.01) ise kontrol grubuna göre yüksek olduğu belirlendi. Hematolojik analizlerde sepsisli buzağıların total lökosit (WBC, p<0.001), monosit (MID, p<0.001), granülosit (GRA, p<0.01), ortalama korpuskuler volüm (MCV, p<0.01), ortalama korpuskuler hemoglobin (MCH, p<0.001) ve ortalama korpuskuler hemoglobin konsantrasyonu (MCHC, p<0.01) düzeyleri kontrol grubu değerlerine göre yüksek bulundu. Çalışmada yapılan biyokimyasal analizlerde ise sepsisli buzağıların total bilirubin (T.BİL, p<0.01), direkt bilirubin (D.BİL, p<0.001), üre (ÜRE, p<0.001), kreatinin (KREA, p<0.001), aspartat aminotrasferaz (AST, p<0.01) ve laktat dehidrojenaz, p<0.001) değerlerinde kontrol grubuna göre anlamlı artışlar saptanırken total protein (TP, p<0.01), albümin (ALB, p<0.001) ve immunoglobulin (Ig, p<0.001) düzeylerinde ise önemli düzeyde düşüşler belirlendi. Yatar pozisyonda olan sepsisli (şiddetli) grupta ayakta olan (orta derecede) sepsisli buzağılara göre daha çok sayıda buzağıda hematolojik ve biyokimyasal parametrelerde değişimler belirlendi. Elde edilen TP ve Ig sonuçları sepsisli buzağılarda yetersiz kolostrum alındığını ve pasif immun transfer yetmezliğinin geliştiğini göstermektedir. Sonuç olarak sepsis neonatal buzağılarda önemli hematolojik ve biyokimyasal değişimlere neden olmakta ve kalp, karaciğer ve böbrekler gibi organların fonksiyonlarını negatif yönde etkilemektedir. Elde edilen bu sonuçların sepsisli buzağıların tanısı, tedavisinin yönlendirilmesi ve prognozunun belirlenmesinde yararlı olacağı kanısındayız.

Anahtar Kelimeler: Biyokimya, Buzağı, Hematoloji, Monitörizasyon, Sepsis.

Keywords

• Biyokimya,Buzağı,Hematoloji,Monitörizasyon

References

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