Kuru Göz Sendromlu Hastaların Tedavisinde %0.05 Siklosporin A’nın Etkinliği

Abstract

Kuru göz, yaşlı popülasyonda en sık görülen oküler hastalıklardan biridir ve önemi giderek artmaktadır. Yaşlanma, azalmış hormonlar ve sistemik otoimmünite kuru göz hastalığının yaygın nedenleri arasındadır. Kuru göz etiyolojisi değişebilse de ana nedenin hem lakrimal bezlerde hem de oküler yüzeylerde inflamasyon olduğu bilinmektedir. Kuru gözün tedavisinde immün modülatör bir ajan olan topikal siklosporin A (CsA) % 0,05'in etkinliğini değerlendirmek için toplam 51 kuru göz sendromu hastası çalışmaya dahil edildi. Hastaların 41'i kadın, 5'i erkekti. Hastaların ortalama ilaç kullanım süresi 8.72 ± 3.59 ay (6-16 ay) idi. Tedavi öncesi Schirmer skorları ile Sjögren ve Sjögren olmayan grupların 1., 6. ve son kontrollerinde bulunan Schirmer skorları arasında istatistiksel olarak anlamlı bir fark gözlendi (p<0.05). Sjögren ve Non- Sjögren grupları arasında ise anlamlı fark yoktu (p> 0.05). Sonuç olarak hem Sjögren hem de Sjögren olmayan grupların Schirmer ve floresein TBUT skorlarında ve gözyaşı menisküs yüksekliğinde anlamlı bir artış olduğu bulundu.

Keywords

• Kuru göz
• Siklosporin A
• Sjögren sendromu

Efficacy of Cyclosporine A 0.05% in the Treatment of Patients with Dry Eye Syndrome

Abstract

Dry eye is one of the most common ocular diseases in the elderly population and has increasing importance. Aging, decreased hormones and systemic autoimmunity are among the common causes of dry eye disease. Although the etiology of dry eye can change, it is known that the main cause is the inflammation in both lacrimal glands and ocular surfaces. To evaluate the effectiveness of topical cyclosporine A (CsA) 0.05% which is an immune-modulatory agent in the treatment of dry eyes, total of 51 patients with dry eye syndrome were included in our study. Forty-six of the patients were female while 5 patients were male. The mean duration of medication use of the patients was 8.72 ± 3.59 months (6-16 months). There was a statistically significant difference between the pre-treatment Schirmer scores and Schirmer scores found in 1st, 6 th and last month controls of Sjögren and Non-Sjögren groups (p<0.05) while there was no statistically significant difference between Sjögren and Non-Sjögren groups (p>0.05). In conclusion, it was found that there was a significant increase in Schirmer and fluorescein TBUT scores and tear meniscus height of both Sjögren and and Non- Sjögren groups.

Keywords

• Dry eye
• Cyclosporin A
• Sjögren syndrome

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