Investigation of the Relationship between IgG and Telomerase In Simental Cattle In Different Age Groups

Abstract

Preservation of telomere length suggests that it can play an active role in avoiding diseases that can be seen with aging and in avoiding cellular aging. Telomeres shorten slightly with each cell division. Telomerase enzyme is responsible for elongation of telomere sequences. Immunoglobulins can be thought of as the molecular structure of antibodies. IgG making up 75-80% of antibodies. The aim of this study is to evaluate the levels of IgG and telomerase enzyme, which have an important place in the immune system with aging. The research material consisted of a total of 46 animals of Simmental breed, 1-day-old 8 calves, 6-month-old 8calves, 1-year-old 8 calves, 4-year-old 12 and 6-year-old 10 cattle in various farms. After the blood samples taken from the animals were centrifuged, their serums were removed and telomerase enzyme levels and IgG levels were measured and compared by ELISA method. As a result, in this study, it was observed that telomerase enzyme activity decreases with aging. While IgG levels did not decrease in the first four groups, a positive correlation was found between IgG and telomerase values in 6-year-old animals. In addition, no significant difference was observed in animals in the same age groups.

Keywords

• age
• Cattle
• IgG
• telomerase

Investigation of the Relationship between IgG and Telomerase In Simental Cattle In Different Age Groups

Abstract

Preservation of telomere length suggests that it can play an active role in avoiding diseases that can be seen with aging and in avoiding cellular aging. Telomeres shorten slightly with each cell division. Telomerase enzyme is responsible for elongation of telomere sequences. Immunoglobulins can be thought of as the molecular structure of antibodies. IgG making up 75-80% of antibodies. The aim of this study is to evaluate the levels of IgG and telomerase enzyme, which have an important place in the immune system with aging. The research material consisted of a total of 46 animals of Simmental breed, 1-day-old 8 calves, 6-month-old 8calves, 1-year-old 8 calves, 4-year-old 12 and 6-year-old 10 cattle in various farms. After the blood samples taken from the animals were centrifuged, their serums were removed and telomerase enzyme levels and IgG levels were measured and compared by ELISA method. As a result, in this study, it was observed that telomerase enzyme activity decreases with aging. While IgG levels did not decrease in the first four groups, a positive correlation was found between IgG and telomerase values in 6-year-old animals. In addition, no significant difference was observed in animals in the same age groups.

Keywords

• Age
• Cattle
• IgG
• Telomerase

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