Sığırlarda viral nedenli abort olgularının etiyopatogenezi

Yıl 2017, Cilt: 5 Sayı: 1, 66 - 77, 06.11.2017

Fırat Doğan Seval Bilge Dağalp

https://doi.org/10.24998/maeusabed.310964

Cited By: 3

Öz

Ruminant
işletmelerinde öncelikli hedef yüksek et ve süt veriminin yanı sıra sağlıklı
yavru elde edilmesi ve bu şekilde karlılık oranının arttırılmasıdır.
Sığırlarda erken embriyonik ölümler, abortlar, fötal mumifikasyon ve anomalili
yavru doğumları sonucunda önemli ekonomik kayıplarla karşılaşılmaktadır. Bu
olgulara neden olan etkenler arasında viruslar önemli bir paya sahiptir. Viral
enfeksiyonlarda tedavi şansının az olması, hastalığın kısa sürede birçok
hayvana yayılmasından dolayı primer olarak aborta neden olan viral etkenlerin
belirlenmesi oldukça önemlidir.  Viruslar
uterusa kan-plasenta yoluyla, tohumlama-çiftleşme esnasında enfekte semen
yoluyla geçebilir. Bu etkenlerin en yaygın görülenleri ve sığırlarda
primer abort etkenleri Bovine herpes virus-1 (BoHV-1), Bovine viral Diarrhea
Virus (BVDV), Bovine herpes virus-4 (BoHV-4), Mavidil, Akabane ve son yıllarda
ülkemizde de tespit edilen Schmallenberg virus (SBV) enfeksiyonlarıdır. Bu
virusların yanı sıra sığırlarda abort etkeni olarak Rift
Valley Fever (RVFV), Epizootic hemorajik disease virus (EHDV), Aino Virus,
Wesselborn Virus, Lumpy skin disease (LSD), Bovine parvovirus da
sayılabilmektedir. Bu derlemede,
sığırlarda primer olarak aborta neden olan viruslar ve abort olgularının
oluşumundaki rolleri ile söz konusu viruslara karşı kontrol/eradikasyon
yöntemleri irdelenmiştir.

Anahtar Kelimeler

Abort, kontrol/eradikasyon, patogenez, sığır, virus

Kaynakça

• Ackermann M, Engels M, 2006. Pro and contra IBR-eradication.Veterinary microbiology, 113(3), 293-302.
• Albayrak H, Özan E, 2010. Orta karadeniz bölgesinde ruminant ve tek tırnaklılarda kan emici sineklerle nakledilen bazı arboviral enfeksiyonların seroprevalansı. Kafkas Universitesi Veteriner Fakultesi Dergisi, 16, 33-36.
• Alkan F, Özkul A, Bılge-Dagalp S, Yesılbag K, Oguzoglu T, Akça, Y, 2000. Virological and serological studies on the role of PI-3 [parainfluenza 3] virus, BRSV [bovine respiratory syncytial virus], BVDV [bovine viral diarrhoea virus] and BHV-1 [bovine herpesvirus 1] on respiratory infections of cattle. I. The detection of etiological agents by direct immunofluorescence technique.Deutsche Tierärztliche Wochenschrift, 107(5), 193-195.
• Anonim 1980. Epizootiology diagnosis and control of bluetongue in Turkey. Bull.off.ent.Epiz.92(7-8):567-564.
• Avcı O, Yavru S, 2013. Investigation of Bovine Herpesvirus-1, Bovine Viral Diarrhea Virus and Bovine Herpesvirus-4 in a dairy herd with naturally infected in Konya. Eurasian Journal of Veterinary Sciences, 29(2), 82-86.
• Azkur A. K, Albayrak H, Risvanli A, Pestil Z, Ozan E, Yılmaz O, Tonbak S, Cavunt A, Kadı H, Macun H.C, Acar D, Özenç E, Alparslan S, Bulut H, 2013. Antibodies to Schmallenberg virus in domestic livestock in Turkey. Tropical animal health and production, 45(8), 1825-1828.
• Bagley C.V, 1999. Abortion in cattle. Animal healty fact sheet, A/H beef/36.
• Bilge S, 1996. Kan ve süt serumu örneklerinde IBR-IPV antikorlarının nötralizasyon testi ile saptanması ve süt örneklerinden virus izolasyonu. Doktora Tezi, AÜ Sağlık Bilimleri Enstitüsü.
• Bilge Dagalp S, Demir A. B, Gungor E, Alkan F, 2007. The seroprevalence of Bovine Herpes Virus Type 4 (BHV4) infection in dairy herds in Turkey and possible interaction with reproductive disorders. Revue de médecine vétérinaire, 158(4), 201.
• Bilge Dağalp S, Oğuzoğlu T.C, Faraji A, Timurkan M.Ö, 2011. The investigation of BVDV, BoHV-4 and BoHV-1 as a possible aetiological agents in abortion and neonatal death cases in cattle. 8. ESVV Pestivirus Sempozyumu,25-28 Eylül 2011, Hannover-Almanya.
• Bilk S, Schulze C, Fischer M, Beer M, Hlinak A, Hoffmann B, 2012. Organ distribution of Schmallenberg virus RNA in malformed newborns. Veterinary microbiology, 159(1), 236-238.
• Blanchard P. C, Ridpath J. F, Walker J. B, Hietala S. K, 2010. An outbreak of late-term abortions, premature births, and congenital deformities associated with a bovine viral diarrhea virus 1 subtype b that induces thrombocytopenia. Journal of veterinary diagnostic investigation, 22(1), 128-131.
• Brock, K. V, McCarty, K, Chase, C. C. L, Harland, R. 2006. Protection against fetal infection with either bovine viral diarrhea virus type 1 or type 2 using a noncytopathic type 1 modified-live virus vaccine. Veterinary Therapeutics, 7(1), 27.
• Brownlie J, Hooper L. B, Thompson I, Collins M. E, 1998. Maternal recognition of foetal infection with bovine virus diarrhoea virus (BVDV)—the bovine pestivirus. Clinical and diagnostic virology, 10(2), 141-150.
• Burgu İ, Alkan F, Özkul A, Yeşilbağ K, Karaoğlu M.T, Güngör B, 2003. Türkiye'de süt sığırcılığı işletmelerinde bovine viral diarrhoea virus (BVDV) enfeksiyonunun epidemiyolojisi ve kontrolü. Ankara Üniv. Vet. Fak. Derg, 50, 127-133.
• Castrucci G, Frigeri F, Ferrari M, Pedini B, Aldrovandi V, Cill, V, Gatti R, 1987. Reactivation in calves of latent infection by Bovid herpesvirus-4. Microbiologica, 10(1),37-45.
• Chaignat V, Worwa G, Scherrer N, Hilbe M, Ehrensperger F, Batten C, Hofmann M, Thuer B, 2009. Toggenburg Orbivirus, a new bluetongue virus: initial detection, first observations in field and experimental infection of goats and sheep. Veterinary microbiology, 138(1), 11-19.
• Czaplicki G, Thiry E, 1998. An association exists between bovine herpesvirus-4 seropositivity and abortion in cows. Preventive veterinary medicine, 33(1), 235-240.
• Çabalar M, ve Akca Y, 1994. Fertilite problemli ineklerde enfeksiyöz bovine rhinotracheitis infeksiyöz pustular vulvovaginitis (IBR-IPV) virus izolasyonu ve seroepidemiyolojisi. Ankara Üniv Vet Fak Derg, 41(3-4), 337-349.
• Fabian K, Makrai L, Sachse K, Szeredi L, Egyed L, 2008. An investigation of the aetiological role of bovine herpesvirus 4 in bovine endometritis. The Veterinary Journal, 177(2), 289-292.
• Frazier K. S, Baldwin C. A, Pence M, West J, Bernard J, Liggett A, Hines, M. E, 2002. Seroprevalence and comparison of isolates of endometriotropic bovine herpesvirus-4. Journal of Veterinary Diagnostic Investigation, 14(6), 457-462.
• Gençay A, Dağalp S. B, Şahna K. C, Pınar D, Başaran Z, 2009. Kayseri Bölgesindeki Sığırlarda Bovine Herpesvirus Tip 1 (BHV-1) Enfeksiyonunun Seroprevalansı. F.Ü.Sağ.Bil.Vet.Derg. 2009: 23 (1): 47 - 52
• Givens M. D, Marley M. S. D, 2008. Infectious causes of embryonic and fetal mortality. Theriogenology, 70(3), 270-285.
• Graham D. A, McNeill G. J, Calvert V, Mawhinney K, Curran W, Ball N. W, Todd D, 2005. Virological and serological evidence of bovine herpesvirus type 4 in cattle in Northern Ireland. Veterinary record, 157(18), 539.
• Gür S, 2008. A serologic investigation of blue tongue virus (BTV) in cattle, sheep and gazella subgutturosa subgutturosa in southeastern Turkey. Tropical animal health and production, 40(3), 217-221.
• Gür S, Doğan N, 2010. The possible role of bovine herpesvirus type‐4 infection in cow infertility. Animal science journal, 81(3), 304-308.
• Gürçay M, İssi M, Gül Y, 2013. Investigation of bovine viral diarrhoea virus in dairy cattle premises where aborts occur. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 10(2).
• Hofmann M. A, Renzullo S, Mader M, Chaignat V, Worwa G, Thuer B, 2008. Genetic characterization of toggenburg orbivirus, a new bluetongue virus, from goats. Switzerland. Emerging infectious diseases, 14(12), 1855.
• Hoffmann B, Beer M, 2009. Bluetongue disease in Germany (2007–2008): monitoring of entomological aspects. Parasitology research, 105(2), 313-319.
• Hoffmann B, Scheuch M, Höper D, Jungblut R, Holsteg M, Schirrmeier H, Eschbaumer M, Goller K.V, Wernike K, Fischer M, Breithaupt A, Mettenleiter T.C, Beer M, 2012. Novel orthobunyavirus in cattle, Europe, 2011. Emerg Infect Dis, 18(3), 469-472.
• Homan E. J, Easterday B. C, 1980. Isolation of bovine herpesvirus-1 from trigeminal ganglia of clinically normal cattle. American journal of veterinary research, 41(8), 1212.
• Kale M, Ata A, Kocamüftüoglu M, Hasircioglu S, 2011. Bovine herpesvirus type 4 (BHV-4) infection in relation to fertility in repeat breeder dairy cows. Acta veterinaria, 61(1), 13-19.
• Karaoğlu M.T, Özgünlük I, Demir A, Özkul A, Burgu I, 2007. Seroprevalence of culicoides-borne disease in cattle in European Turkey. Ankara Üniv Vet Fak Derg, 54, 121-125.
• Kirkbride C. A, 1990. Infectious bovine rhinotracheitis (bovine herpesvirus group 1) viral abortion. KIRKBRIDE, CA (Ed.) Laboratory diagnosis of livestock abortion, 3, 91-97.
• Maan S, Maan N. S, Nomikou K, Batten C, Antony F, Belaganahalli M. N, Samy A.M, Reda A.A, Al-Rashid S.A, El-Batel M, Oura, C. A, Mertens P.C, 2011. Novel bluetongue virus serotype from Kuwait.Emerg Infect Dis, 17(5), 886.
• Maclachlan N. J, 2010. Global implications of the recent emergence of bluetongue virus in Europe. Veterinary Clinics of North America: Food Animal Practice, 26(1), 163-171.
• Mehlhorn H, Walldorf V, Klimpel S, Schaub G, Kiel E, Focke R, Liebisch G, Liebisch a., Werner D, Bauer C, Clausen H, Bauer B, Geier M, Hörbrand T, Bätza H.J, Conraths F.J, Mellor P. S, Wittmann E. J, 2002. Bluetongue virus in the Mediterranean Basin 1998–2001. The Veterinary Journal, 164(1), 20-37.
• Menzies F. D, McCullough S. J, McKeown I. M, Forster J. L, Jess S, Batten C, Murchie A.K, Gloster J, Fallows J.G, Pelgrim W, Mellor P. S, 2008. Evidence for transplacental and contact transmission of bluetongue virus in cattle. The Veterinary Record, 163(7), 203.
• Miller J. M, Whetstone C. A, Van der Maaten M. J, 1991. Abortifacient property of bovine herpesvirus type 1 isolates that represent three subtypes determined by restriction endonuclease analysis of viral DNA. American journal of veterinary research, 52(3), 458-461.
• Monge A, Elvira L, Gonzalez J. V, Astiz S, Wellenberg G. J, 2006. Bovine herpesvirus 4-associated postpartum metritis in a Spanish dairy herd. Research in veterinary science, 80(1), 120-125.
• Murphy F. A, Gibbs E. P. J, Horzinek M. C, Studdert M. J, 1999. Veterinary virology 3th edition. Academic press. United State of America.
• Oğuzoğlu T. Ç, Toplu N, Koç B. T, Doğan F, Epikmen E. T, İpek E, Akkoç A. N, 2015. First molecular detection and characterization of Akabane virus in small ruminants in Turkey. Archives of virology, 160(10), 2623-2627.
• Osorio F.A, Reed D.E, 1983. Experimental inoculation of cattle with BHV4 evidence for a lymhoid associated persistent infection. Am J Vet Res, 44, 975-980.
• Otter A, de B Welchman D, Sandvik T, Cranwell M. P, Holliman A, Millar M. F, Scholes S. F. E, 2009: Congenital tremor and hypomyelination associated with bovine viral diarrhoea virus in 23 British cattle herds. Veterinary Record: Journal of the British Veterinary Association,164(25).
• Özgünlük İ, Yıldırım Y, Gür S, Tan M. T, 2013. Aydın Yöresindeki Sığırlarda Akabane Virus (AKAV) ve İbaraki Virus (IBAV) Enfeksiyonlarının Seroprevalansı. Harran Üniv Vet Fak Derg, 2(1) 36-41;2013.
• Öztürk D, Kale M, Pehlivanoğlu F, Hasırcıoğlu S, Türütoğlu H, 2012. Evaluation for some bacterial and viral abortions of dairy cattle farms in Burdur district of Turkey. Kafkas Univ Vet Fak Derg 18 (2): 255-258,
• Rodger S. M, Murray J, Underwood C, Buxton D, 2007. Microscopical lesions and antigen distribution in bovine fetal tissues and placentae following experimental infection with bovine herpesvirus-1 during pregnancy. Journal of comparative pathology, 137(2), 94-101.
• Roizmann B, Desrosiers R. C, Fleckenstein B, Lopez C, Minson A. C, Studdert M. J, 1992. The familyHerpesviridae: an update. Archives of virology, 123(3-4), 425-449.
• Schlafer D. H, Miller R. B, 2007. Pathology of the gravid uterus, placenta, and fetus. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals, Maxie MG, ed, 3, 474-564.
• Smith K. C, 1997. Herpesviral abortion in domestic animals. The Veterinary Journal, 153(3), 253-268.
• Sperlova A, Zendulkova D, 2011. Bluetongue: a review. Vet Med-Czech,56(9), 430-452.
• Tan M. T, Karaoğlu M. T, Erol N, Yildirim Y, 2006. Serological and virological investigations of bovine viral diarrhoea virus (BVDV) infection in dairy cattle herds in Aydın province. Turkish Journal of Veterinary and Animal Sciences, 30(3), 299-304.
• Uchida K, Murakami T, Sueyoshi M, Tsuda T, Inai K, Acorda,J. A, Yamaguchi S, Tateyama, S, 2000. Detection of Akabane viral antigens in spontaneous lymphohistiocytic encephalomyelitis in cattle. Journal of veterinary diagnostic investigation, 12(6), 518-524.
• Varela M, Schnettler E, Caporale M, Murgia C, Barry G, McFarlane M, McGregor E, Piras I.M, Shaw A, Janowicz, A, Beer M, Glass M, Herder V, Hahn K, Baumgärtner W, Kuhl A, Palmarini M, 2013. Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host. PLoS Pathog, 9(1), e1003133.
• Waldvogel A. S, Anderson G. A, Phillips D. L, Osburn B. I, 1992. Association of virulent and avirulent strains of bluetongue virus serotype 11 with premature births of late-term bovine fetuses. Journal of comparative pathology, 106(4), 333-340.
• Wellemans G, Van Opdenbosch E, Mammerickx M, 1985. Experimental inoculation of bovine herpesvirus 4 (strain LVR 140) in pregnant and nonpregnant cows. Annales de recherches veterinaires. Annals of veterinary research, 17(1), 89-94.
• Wellenberg G. J, Van der Poel W. H. M, Van Der Vorst T. J. K, Van Valkengoed P. H. R, Schukken Y. H, Wagenaar F, Van Oirschot J. T, 2000. Bovine herpesvirus 4 in bovine clinical mastitis. Veterinary Record,147(8), 222-225.
• Yildirim Y, Yilmaz V, Kalaycioglu A. T, Dagalp S. B, Majarashin A. R. F, Celebi O, Akca D, 2011. An investigation of a possible involvement of BVDV, BHV-1 and BHV-4 infections in abortion of dairy cattle in Kars district of Turkey. Kafkas Univ. Vet. Fak. Derg, 17, 879-883.
• Yonguc A. D, Taylor W. P, Csontos L, Worrall E, 1982. Bluetongue in western Turkey. The Veterinary record, 111(7), 144-146.