Adipoz doku ve adipoz dokudan salgılanan bazı proteinler

Yıl 2017, Cilt: 5 Sayı: 2, 155 - 179, 25.12.2017

Şule Demirci Cennet Gün

https://doi.org/10.24998/maeusabed.338105

Cited By: 5

Öz

Gelişmiş ve gelişmekte olan ülkelerde
yaşam şartlarının değişmesi nedeniyle hareketsizlik ve aşırı yağlı gıdalarla
beslenme sonucu obezite yaygın olarak görülmektedir.
Yapılan çalışmalarda obezitenin aslında düşük seviyede seyreden kronik bir
adipoz doku yangısı olduğu ve bu durumun obezite ilişkili sistemik metabolik
fonksiyon bozukluklarına katkıda bulunduğu ortaya konmuştur.

 Adipoz dokudan salgılanan adipokinler, metabolik
ve/veya pro/antiinflamatuar etkilere sahip olan biyoaktif maddelerdir.
Obezitedeki adipoz doku disfonksiyonu nedeniyle bu adipokinlerin yapımı veya
salgılanmasının düzensizliği birçok hastalık komplikasyonları oluşturmakta,
yaşam koşullarının kalitesinin azalmasına ve mortalite oranının artmasına neden
olmaktadır. Bu derlemede, farklı adipoz doku yapıları, yapılarına göre değişen
fonksiyonları ve adipoz dokudan salgılanan pro/anti inflamatuar ve enerji
dengesinde etkili adipokinlerden bazıları hakkında bilgi verilmesi
amaçlanmıştır.

Anahtar Kelimeler

Adipoz doku, adipokin, sitokin, obezite

Kaynakça

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