Fare Blastosistlerinde Hücre Kaderinin Belirlenmesi

Yıl 2017, Cilt: 5 Sayı: 2, 219 - 227, 25.12.2017

Cennet Sinem Çoban Duygu Mutluay

https://doi.org/10.24998/maeusabed.352205

Öz

Farelerde preimplantasyon embriyo gelişimi blastosistin uterus
duvarına tutunması ile son bulur. Blastosist dönemi hem implantasyon hem de
gebelik için kritik bir süreçtir. E 3.5 dönemindeki fare blastosistleri
trofektoderm (TE) ve iç hücre kütlesi (ICM) olmak üzere iki hücre soyundan
oluşur. Daha sonradan plasentayı meydana getirecek olan TE hücreleri annenin
uterus ile bağlantı kurarken ICM hücreleri fetusu ve ekstra embriyonik dokuları
meydana getirir. E3.5 blastosist döneminden sonra ICM hücreleri pluripotent
epiblast (Epi) ve primitif endoderm (PrE) olmak üzere iki farklı embriyonik
soya farklılaşır. Bu üç hücre soyunun (TE, PrE, Epi) başarılı bir şekilde
oluşumu embriyo modellenmesi, implantasyon ve embriyonik gelişimin
sürdürülebilmesi bakımından kritik bir önem taşır.  Bu makalede 
fare embriyo gelişiminde erken soy belirlenmesinde rol oynayan hücresel
ve moleküler mekanizmalar hakkında bilgiler derlenmiştir. Bu süreçlerin
anlaşılması hem başarılı bir implantasyon ve fetal gelişimin sağlanması
amacıyla kullanılan yardımcı üreme tekniklerinin, aynı zaman da erken düşükler
ve gebelik patolojilerinin nedenlerinin ortaya konulması bakımından önemlidir.

Anahtar Kelimeler

blastosist, fare, hücre farklılaşması, hücre soyu, preimplantasyon gelişimİ

Kaynakça

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