Investigation of antifungal and antioxidant properties of Capparis ovata methanolic extracts

Year 2018, Volume: 6 Issue: 2, 60 - 66, 30.12.2018

Hamit Uslu , Dinçer Erdağ Gözde Atila , Kemal Metiner , Baran Çelik , Asım Kart , Fatma Esin Kırık Oktay Ozkan

https://doi.org/10.24998/maeusabed.460081

Cited By: 1

Abstract

Caper plant belonging to the genus Capparis (family Capparaceae) is a plant used in traditional medicine to cure
various illnesses since ancient times. Studies have shown significant medicinal
properties of various Capparis
species. This study was designed to examine in
vitro antifungal and antioxidant activity of methanolic extracts of Capparis ovata buds. It was determined
that Capparis ovata inhibited the NO
radical in a dose-dependent manner and exhibited reducing power activity.
According to the standard pyrocatechol graph, 1 mg of Capparis ovata contains 19.64 µg of phenolic equivalent of
pyrocatechol. In vitro antifungal
susceptibilty testing of Capparis
ovata methanolic extract against eight different fungal strains were determined by broth macrodilution
method. According to MIC values of in vitro antifungal activity testing Capparis ovata has moderate antifungal
activity.  In conclusion, Capparis ovata was found to have a significant antifungal and
antioxidant potential. Hence, this plant could have the potential to be used
against fungal and oxidative stress 
related many disease conditions. 

Keywords

Capparis ovata, Antifungal, Antioxidant

References

• 1. Duman, E., Özcan, M.M., 2014. Physicochemical properties of seeds of Capparis species growing wild in Turkey. Environmental Monitoring and Assessment 186(4), 2393-2398.2. Belviranlı, B., Özcan, M. M., Özcan, M.M., 2016. Chemical and microbiological properties of pickling of caper (Capparis ovata Desf. var. canescens) fruits. Journal of Agroalimentary Processes and Technologies 22(2), 95-1013. 3. Lansky, E. P., Paavilainen, H. M., Lansky, S., 2013. Caper: the genus Capparis. CRC Press. Taylor & Francis Group, Newyork, 345s.4. Arslan, R., Bektas, N., Ozturk, Y., 2010. Antinociceptive activity of methanol extract of fruits of Capparis ovata in mice. Journal of Ethnopharmacology 131(1), 28-32.5. Haciseferoğullarİ, H., Özcan, M. M., Duman, E., 2011. Biochemical and technological properties of seeds and oils of Capparis spinosa and Capparis ovata plants growing wild in Turkey. Journal of Food Processing and Technology 2(6), 1000129.6. Tlili, N., Elfalleh, W., Saadaoui, E., Khaldi, A., Triki, S., Nasri, N., 2011. The caper (Capparis L.): Ethnopharmacology, phytochemical and pharmacological properties. Fitoterapia 82(2), 93-101.7. Kondawar M.S., Kamble K.G., Khandare M.M., Maharshl K.H., Awale V.B., 2011. Evaluation of the locomotor and diuretic activities of ethanolic extract of leaves of Capparis divaricata lam. (capparidaceae). International Journal of Pharmacy and Pharmaceutical Sciences 3(4), 265-267. 8. Zia-Ul-Haq M., Ćavar S., Qayum M., Imran I., Feo V.D., 2011. Compositional Studies: Antioxidant and Antidiabetic Activities of Capparis decidua (Forsk.) Edgew. International Journal of Molecular Sciences 12, 8846-8861.9. Mishra S.N., Tomar P.C., Lakra N., 2007. Medicinal and food value of Capparis a hersh terrain plant. Indian Journal of Traditional Knowledge 6(1), 230-238.10. Aqil, F., Zahin, M., Ahmad, I., Owais, M., Khan, M. S. A., Bansal, S. S., Farooq, S., 2010. Antifungal activity of medicinal plant extracts and phytocompounds: A review. In Combating Fungal Infections.Springer, Berlin, Heidelberg. 449-484.11. Ali, S. S., Kasoju, N., Luthra, A., Singh, A., Sharanabasava, H., Sahu, A., Bora, U., 2008. Indian medicinal herbs as sources of antioxidants. Food Research International 41(1), 1-15.12. Krishnaiah, D., Sarbatly, R., Nithyanandam, R., 2011. A review of the antioxidant potential of medicinal plant species. Food and Bioproducts Processing 89(3), 217–233.13. Özkan O., Gül S., Kart A., Çiçek B.A., Kılıç K., 2013. In Vitro Antimutagenicity of Allium Tuncelianum Ethanol Extract Against Induction of Chromosome Aberration by Mutagenic Agent Mitomycine C. Kafkas Universitesi Veteriner Fakültesi Dergisi 19 (2), 259-262.14. CLSI, 2008a. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; Approved standard CLSI document M38-A2. Clinical and Laboratory Standards Institute, Wayne, PA, USA.15. CLSI, 2008b. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved. Standard, Third Edition. CLSI document M27-A3. Clinical and Laboratory Standards Institute, Wayne, PA, USA.16. Badami S., Gupta M.K., Suresh B., 2003. Antioxidant activity of the ethanolic extract of Striga orobanchioides. Journal of Ethnopharmacology 85,227–30.17. Kumar R.S., Sivakumar T., Sunderam R.S., Gupta M., Mazumdar U.K., Gomathi P., Rajeshwar Y., Saravanan S., Kumar M.S., Murugesh K., Kumar K.A., 2005. Antioxidant and antimicrobial activities of Bauhinia racemosa L. stem bark. Brazilian Journal of Medical and Biological Research 38,1015–24.18. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., Tannenbaum S.R., 1982. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids, Anals of Biochemistry 126,131–8.19. Oyaizu M., 1986. Studies of products browning reaction: antioxidative activity of products of browning reaction prepared from glucosamine. Japanese Journal of Nutrition 44:307–15.20. Slinkard K., Singleton V.L., 1977. Total phenol analysis: automation and comparison with manual methods. The American Journal of Enology and Viticulture 28,49–55.21. El-Ghorab, A., Shibamoto, T., Özcan M.M., 2007. Chemical composition and antioxidant activities of buds and leaves of capers (Capparis ovata Desf. var. canescens) cultivated in Turkey. Journal of Essential Oil Research 19(1), 72-77.22. Nazıroğlu, M., Akay, M. B., Çelik, Ö., Yıldırım, M. İ., Balcı, E., & Yürekli, V.A., 2013. Capparis ovata modulates brain oxidative toxicity and epileptic seizures in pentylentetrazol-induced epileptic rats. Neurochemical Research 38(4), 780-788.23. Unver, A., Arslan, D., Ozcan, M. M., & Akbulut, M., 2009. Phenolic content and antioxidant activity of some spices. World Applied Sciences Journal 6(3), 373-377.24. Duman, H., Canatan, D., Alanoglu, G., Sutcu, R., Nayir, T., 2013. The antioxidant effects of Capparis ovata and deferasirox in patients with thalassemia major. Journal of Blood Disorders & Transfusion 4(3), 325. Nazıroğlı M., 2011. Capparis ovata modulates ovariectomize induced-oxidative toxicity in brain, kidney and liver of aged mice. Cell Membranes and Free Radical Research 3(2), 186-193.26. Zia-Ul-Haq M., Ćavar S. , Qayum M., Imran I., Feo W., 2011. Compositional Studies: Antioxidant and Antidiabetic Activities of Capparis decidua (Forsk.) Edgew. International Journal of Molecular Sciences 12(12), 8846-8861.27. El-Ghorab A., Shibamoto T., Özcan M.M., 2007. Chemical Composition and Antioxidant Activities of Buds and Leaves of Capers (Capparis ovata Desf. var. canescens) Cultivated in Turkey. Journal of Essential Oil Research 19, 72–77.28. Yang T., Wang C., Liu H., Chou G., Cheng X., Wang Z., 2010. A new antioxidant compound from Capparis spinosa. Journal Pharmaceutical Biology 48, (5). 589-594 .29. Aslam, A. Q. S. A., Naz, F., Arshad, M., Qureshi, R., Rauf, C.A., 2010. In vitro antifungal activity of selected medicinal plant diffusates against Alternaria solani, Rhizoctonia solani and Macrophomina phaseolina. Pakistan Journal of Botany 42(4), 2911-2919.30. Sharma, B., Kumar, P., 2009. In vitro antifungal potency of some plant extracts against Fusarium oxysporum. International Journal of Green Pharmacy 3(1), 63.31. Keymanesh, K., Hamedi, J., Moradi, S., Mohammadipanah, F., Sardari, S. 2009. Antibacterial, antifungal and toxicity of rare Iranian plants. International Journal of Pharmacology 5, 82-85.32. Malabadi, R. B., Vijay Kumar, S., 2007. Assessment of antifungal activity of some medicinal plants. International Journal of Pharmacology 3(6), 499-504.33. Buwa, L. V., Van Staden, J., 2006. Antibacterial and antifungal activity of traditional medicinal plants used against venereal diseases in South Africa. Journal of Ethnopharmacology 103(1), 139-142.34. Anywar, G., Oryem-Origa, H., Kamatenesi-Mugisha, M., 2014. Antibacterial and Antifungal Properties of Some Wild Nutraceutical Plant Species from Nebbi District, Uganda. British Journal of Pharmaceutical Research 4(14), 1753-1761.35. Rathee, S., Rathee, P., Rathee, D., Rathee, D., 2013. Antimicrobial Activity of Oleiyl Glucoside Isolated from the Traditional Medicinal Plant, Capparis decidua. The Natural Products Journal 3(1), 52-59.36. Lam SK., Ng TB., 2009. A protein with antiproliferative, antifungal and HIV-1 reverse transcriptase inhibitory activities from caper (Capparis spinosa) seeds. Phytomedicine 16 (5), 444-450.