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            <front>

                <journal-meta>
                                                                <journal-id>makufebed</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Mehmet Akif Ersoy Üniversitesi Fen Bilimleri Enstitüsü Dergisi</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">1309-2243</issn>
                                                                                            <publisher>
                    <publisher-name>Burdur Mehmet Akif Ersoy Üniversitesi</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id/>
                                                                                                                                                                                            <title-group>
                                                                                                                        <article-title>Developmental disorders caused by Verbascum speciosum Schrad. Extracts in Drosophila melanogaster (Diptera: Drosophilidae)</article-title>
                                                                                                                                                                                                <trans-title-group xml:lang="tr">
                                    <trans-title>Developmental disorders caused by Verbascum speciosum Schrad.  Extracts in Drosophila melanogaster (Diptera: Drosophilidae)</trans-title>
                                </trans-title-group>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                <name>
                                    <surname>Uysal</surname>
                                    <given-names>Hasan</given-names>
                                </name>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Aksakal</surname>
                                    <given-names>Özkan</given-names>
                                </name>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Askın</surname>
                                    <given-names>Hakan</given-names>
                                </name>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20151221">
                    <day>12</day>
                    <month>21</month>
                    <year>2015</year>
                </pub-date>
                                        <volume>3</volume>
                                        <issue>2</issue>
                                        <fpage>7</fpage>
                                        <lpage>11</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20151222">
                        <day>12</day>
                        <month>22</month>
                        <year>2015</year>
                    </date>
                                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2010, Mehmet Akif Ersoy Üniversitesi Fen Bilimleri Enstitüsü Dergisi</copyright-statement>
                    <copyright-year>2010</copyright-year>
                    <copyright-holder>Mehmet Akif Ersoy Üniversitesi Fen Bilimleri Enstitüsü Dergisi</copyright-holder>
                </permissions>
            
                                                                                                <abstract><p>The effect of aqueous seed extracts of Verbascum speciosum on the development biology of Drosophilamelanogaster was determined. Various doses of boiled and unboiled extracts (2, 4, 6, 8 and 10 mg/100 mL standardDrosophila medium (SDM)) were added to the standard medium of D. melanogaster. The use of the seed extractssignificantly increased the mortality of the F1 generation. Emerged individuals belonging to F1 decreased with anincrease in dose (P&amp;lt;0.05). In addition, severe malformations were observed belonging to different extremities in thenewly-emerged flies of F1 progeny. The results showed that unboiled seed extracts of V. speciosum are more toxic toD. melanogaster than their boiled counterpart (Vsb&amp;lt;Vsub).Keywords: Drosophila melanogaster, Verbascum speciosum, developmental biology, mortality</p></abstract>
                                                                                                                                    <trans-abstract xml:lang="tr">
                            <p>Bu çalışmada, Drosophila melanogaster’in gelişim biyolojisi üzerine Verbascum speciosum’a ait tohumların su ekstraktlarının etkileri araştırılmıştır. Bu amaçla, kaynatılmış ve kaynatılmamış tohum ekstraktlarının farklı dozları (2, 4, 6, 8 ve 10 mg/100 mL SDB) D. melanogater’in standart besiyerine ilave edilmiştir. Bu ekstraktların kullanılmasıyla F1 neslinde ölüm oranının önemli bir ölçüde arttığı gözlenmiştir. Doz artışına bağlı olarak F1 nesline ait birey sayısı azalmıştır (P</p></trans-abstract>
                                                            
            
                                                            <kwd-group>
                                                    <kwd>-</kwd>
                                            </kwd-group>
                                                        
                                                                            <kwd-group xml:lang="tr">
                                                    <kwd>Verbascum speciosum</kwd>
                                                    <kwd>   Drosophila melanogaster</kwd>
                                                    <kwd>   gelişim biyolojisi</kwd>
                                                    <kwd>   mortalite</kwd>
                                            </kwd-group>
                                                                                                            </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">Ahmed, B., Al-Rehaily, A.J., Al-Howiriny, T.A., El-Sayed, K.A., Ahmad, M.S. (2003). Scropolioside-D2 and harpagoside -B: two new iridoid glycosides from Scrophularia deserti and their antidiabetic and anti-inflammatory activity. Biol Pharm Bull, 26, 462–467.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">Akdemir, Z.S., Tatli, I.I., Bedir, E., Khan, I.A. (2005). Two new iridoid glycosides from Verbascum salviifolium, Boiss. Zeitschrift fur Naturforschung B, 60, 113–117.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">Baytop, T. (1999). Therapy with Medicinal Plants in Turkey (Past and Present), Nobel Tıp Kitabevleri Ltd., İstanbul, pp. 334.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">Beard, R.L, Walton, G.S. (1971). Insecticidal mycotoxins produced by Aspergillus flavus var. colunaris. Bull Conn Agr Exp Sta, 725, 1-26.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">Dulger, B., Kirmizi, S., Arslan, H., Güleryüz, G. (2007). Antimicrobial Verbascum species. Pharm Biol, 40, 587–589. of three endemic</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">Elgindi, M.R., Mabry, T.J. (2000). Phenyletanoid glycosides from Verbascum siniaticum. Asian J Chem, 12, 127–130.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">Giner, R.M., Villalba, M.L., Recio, M.C., Manez, S., Cerda-Nicolas, M., Rios, J.L. (2000). Anti- inflammatory glycoterpenoids from Scrophularia auriculata. Eur J Pharm, 389, 243–252.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">Graf, U., Würgler, F.E., Katz, A.J., Frei, H., Juon, H., Hall, C.B., Kale, P.G. (1984). Somatic mutation and melanogaster. Environ Mutagen, 6 (2), 153-188. test in Drosophila</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">Hartleb, I., Seifert, K. (1994). Sangarosaponin-D a triterpenoid saponin from Verbacsum songaricu. Phytochem, 35, 1009–1011.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">Huber-Morath, A. (1978). Verbascum in Flora of Turkey and The East Aegean Islands, Vol. 6, Ed: Davis, P.H., University Press, Edinburgh, pp. 461-603.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">Jeyabalan, D., Arul, N., Thangamathi, P. (2003). Studies on effects of Plargonium citrosa leaf extracts on malarial vector, Anopheles stephensi Liston. Bioresour Technol, 89, 185-189.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">Khoshnoud, H., Khayamy, M. (2008). Insecticidal effects of cheiranthifolium Boiss. against two stored-product insect pests species. J Biol Sci, 8(1), 191-195.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">Khoshnoud, H., Ghiyasi, M., Amirnia, R., Fard, SS. (2008). The potential of using insecticidal properties of medicinal plants against insect pest. Pak J Biol Sci, 11(10), 1380-1384.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">Klimek, B. (1996). Hidroxycinnamoyl ester glycosides and saponins from flowers of Verbascum phlomoides. Phytochem, 43, 1281–1284.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">Konoshima, T., Takasaki, M., Tokuda, H., Nishimo, H. (2000). Cancer chemopreventive activity of an iridoid glycoside, 8-acetylharpagide from Ajuga decumbens. Cancer Lett, 157, 87–92.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">Kupeli, E., Tatli, I.I., Akdemir, Z.S., Yesilada, E. (2007). Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoterpenoids from the flowers of Verbascum lasianthum Boiss. ex Bentham. J Ethnopharmacol, 110, 444-450.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">Mostafa, T.Y., Mahgoub, S.M., Ahmed, M.S. (1996). The efficiency of certain plant powders against cowpea weevil Callosobruchus maculates (F.) (Coleoptera: Bruchidae). Egypt J Agric Res, 74, 307-319.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">Paszkiewicz-Gadek, A., Grochowska, K., Galasinski, W. (1990). Effect of the aqueous extract and saponin fraction from the flowers of Verbascum thapsiforme on protein biosynthesis in a rat liver ribosomal system. Phytother Res, 4 (5), 177–181.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">Sadek, M.M. (2003). Antifeedant and toxicity of Adhatoda vasica leaf extract against Spodoptera littoralis (Lep., Noctuidae). J. Applied Entomol, 127, 396-404.</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">Schmutterer, H. (1995). The neem tree Azadirachta indica A. juss and other malicious plant sources of unique natural products of integrated pest management medicine, industry and other purposes,VCH, Veinheim, Federal Republic of Germany.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">Skaltsounis, A.L., Tsitsa-Tzardis, E., Demetzos, C., Harvala, C. (1996). Unduloside, a new iridoid glycoside from Verbascum undulatum. J Nat Prod, 59, 673–675.</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">Stevenson, P.C., Simmonds, M.S.J., Sampson, J., Houghton, P.J., Grice, P. (2002). Wound healing activity of acylated iridoid glycosides from Scrophularia nodosa. Phytother Res, 16, 33–35.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">Tatli, I.I., Akdemir, Z.S., Bedir, E. (2003). 6-O-l- Rhamnopyranosylcatalpol derivative iridoids from Verbascum cilicicum. Turk J Chem, 27, 765–772.</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">Tatli, I.I., Akdemir, Z.S. Bedir, E. (2004). Saponin, iridoid, glycosides from Verbascum pterocalycinum var. mutense. Turk J Chem, 28, 111–122.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">Turker, A.U., Gurel, E. (2005). Common Mullein (Verbascum thapsus L.) Recent Advances in Research, Phytother Res, 19, 7-13.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">Uysal, H., Kaya, Y. (2004). Toxicity of Euphorbia canariensis latex to some developmental stages of Drosophilidae). Bull Environ Contam Toxicol, 72, 45-53. Diptera:</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">Vijayavitthal, T.M., Kanwal, R., Amiya, P.B., Ragini, S., Anju, P., Lalit, M.T., Vishwa, M.L.S. (1998). Studies on the profile of immunostimulant activities of modified iridoid glycosides. Bioorg Med Chem, 6, 605–611.</mixed-citation>
                    </ref>
                                    <ref id="ref28">
                        <label>28</label>
                        <mixed-citation publication-type="journal">Youhnovski, N., Dandarov, K., Guggisberg, A., Hesse, M. (1999). Macrocyclic spermine alcholoids from Verbascum Isolation, structure elucidation and synthesis of the (E/Z)-isomeric pairs(S)- verbasikrine/(S)- verbamekrine/(S)-isoverbamekrine, Helv Chim Acta, 82, 1185–1194. and (S)</mixed-citation>
                    </ref>
                                    <ref id="ref29">
                        <label>29</label>
                        <mixed-citation publication-type="journal">Zhong, G.H., Hu, M.Y., Weng, A.Q. (2001). Laboratory and Rhododendron molle flowers as insect growth regulator to imported cabbage worm, Pieris rapae L. (Lepidoptera:Pieridae). J Appl Entomol, 125, 563-596.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
