Late presentations among HIV-infected patients
Abstract
Objective: The late diagnosis of human immunodeficiency virus (HIV) infection and, therefore, initiation of antiretroviral therapy (ART) in the advanced stages of the disease is still a significant problem in many countries. This study aimed to define the prevalence of late presentation and advanced HIV disease among newly diagnosed HIV infected patients.
Patients and Methods: The medical records of HIV-infected patients aged 18 and over, diagnosed between January 2011 and December 2019, were analysed retrospectively. The patients were grouped into three-year periods according to the date of diagnosis.
Results: Of the 280 patients with HIV infection, 44 (15.7%) were female and 236 (84.3%) were male. It was found that 50.7% of the patients were late presenters, and 28.5% had advanced diseases. There was no statistical difference in the prevalence of late presentation and advanced HIV disease between the three-year periods. While there was no relationship between gender and late presentation, a statistically significant relationship was found between advanced age and late presentation.
Conclusion: Despite advances in the diagnosis and treatment of HIV infection, the frequency of late presentation is still quite high, in Turkey. This situation highlights the importance of broad-based HIV screening programs to control the disease more effectively.
Keywords
References
- [1] European Centre for Disease Prevention and Control [ECDC]. HIV/AIDS surveillance in Europe 2019 – 2018 data. https://www.ecdc.europa.eu/sites/default/files/documents/ hiv-surveillance-report-2019.pdf. Accessed:10 February 2020.
- [2] Jeong SJ, Italiano C, Chaiwarith R et al. Late presentation into care of HIV disease and its associated factors in Asia: results of TAHOD. AIDS Res Hum Retroviruses 2016;32:255-61. doi: 10.1089/AID.2015.0058.
- [3] Panos G, Samonis G, Alexiou VG, Kavarnou GA, Charatsis G, Falagas ME. Mortality and morbidity of HIV infected patients receiving HAART: a cohort study. Curr HIV Res 2008;6:257- 60. doi:10.2174/157.016.208784324976.
- [4] Sobrino-Vegas P, Moreno S, Rubio R et al. Impact of late presentation of HIV infection on short-, mid-and longterm mortality and causes of death in a multicenter national cohort: 2004-2013. J Infect 2016;72:587-96. doi: 10.1016/j. jinf.2016.01.017.
- [5] Jevtović D, Vanovac V, Veselinović M, Salemović D, Ranin J, Stefanova E. The incidence of and risk factors for HIVassociated cognitive–motor complex among patients on HAART. Biomed Pharmacother 2009;63:561-5. doi: 10.1016/j. biopha.2008.09.015.
- [6] Marks G, Crepaz N, Janssen RS. Estimating sexual transmission of HIV from persons aware and unaware that they are infected with the virus in the USA. AIDS 2006;20:1447-50. doi: 10.1097/01.aids.000.023.3579.79714.8d.
- [7] Antinori A, Coenen T, Costagiola D et al. Late presentation of HIV infection: a consensus definition. HIV Med 2011;12:61- 4. doi: 10.1111/j.1468-1293.2010.00857.x.
- [8] Turkey, Ministry of Health. Statistics of HIV-AIDS. Https:// hsgm.saglik.gov.tr/tr/bulasici-hastaliklar/hiv-aids/hiv-aidsliste/ hıv-aids-istatislik.html. Accessed:10 February 2020.
Details
Primary Language
English
Subjects
Clinical Sciences
Journal Section
Research Article
Authors
Heval Can Bılek
*
This is me
0000-0002-4330-3293
Türkiye
Aydin Devecı
This is me
0000-0001-8057-6445
Türkiye
Esra Tanyel
This is me
0000-0002-3151-371X
Türkiye
Publication Date
May 30, 2022
Submission Date
September 30, 2021
Acceptance Date
-
Published in Issue
Year 2022 Volume: 35 Number: 2