The utility of biomarkers to predict steroid response in idiopathic nephrotic syndrome

Abstract

Objective: The most common form of nephrotic syndrome (NS) is minimal change disease (MCD) in children and focal segmental glomerulosclerosis (FSGS) following it. As, it is important to predict corticosteroid (CS) response at the beginning of the disease, we aimed to evaluate the efficacy of some biomarkers in terms of predicting steroid response in patients with NS. Patients and Methods: Twenty patients who met the inclusion criteria for the study were divided into 3 groups and 6 healthy control participants were included in the analysis as the 4th group. Group-1 included 10 patients at the first episode of idiopathic NS (INS), group-2 included the same 10 patients in remission, group-3 included 10 patients with steroid resistant NS (SRNS) diagnosed as FSGS by renal biopsy, and group-4 included six healthy children as controls. Urinary and serum cluster of differentiation (CD) CD80, IL-17, IL-23, IL-10, TGF-β, CD86, CD28, CTLA-4 levels were measured for all groups. Results: Urinary CD80 level in INS-relapse group was significantly higher than the levels of the INS-remission, FSGS and control groups (p<0.001). Urinary CD28 and uIL-10 were significantly increased in INS-remission group than INS-relapse (p<0.05, p<0.001). Serum IL-17 was significantly higher in INS-relapse group than in INS-remission group (p<0.01). There was no difference in IL- 23,TGF-β,CD86 parameters between groups. Conclusion: In our study, urinary CD80 levels were significantly higher in the relapse group compared to the other groups. When supported by more

Keywords

• Biomarkers
• CD80
• Nephrotic syndrome
• Steroid response

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