Clinical and radiological findings in relation to histopathological results of pulmonary nodule resections

Shahab Ghivi; Sehnaz Olgun; Caner Çınar; Cansu Yıldız; Derya Kocakaya; Nezih Onur Ermerak; Emine Bozkurtlar; Özlem Demircioğlu; Hüseyin Arıkan; Feyza Şen; Özlem Ercelep; Cagatay Çimşit; Emel Eryüksel; Sait Karakurt; Bedrettin Yıldızeli

doi:10.5472/marumj.1708833

Clinical and radiological findings in relation to histopathological results of pulmonary nodule resections

Abstract

Objective: Despite technological advances and well-defined clinical scoring, pulmonary nodule management still remains a controversial issue. Due to conflicting situations, many patients are referred to reference centers for evaluation. The aim of this study is to reveal the relationship between clinical, radiological, and histopathological findings of patients with surgically resected pulmonary nodules who were followed-up by a multicisciplinary team at a 3rd level reference center. Patients and Methods: Patients, who were followed-up by the multidisciplinary team and underwent surgical resection per the multidisciplinary team’s recommendations between October, 2018 and December, 2021, were included in the study. Results: A total 209 eligible patients were identified. 133 (63.6%) patients had solitary pulmonary nodules, 61 (29.3%) patients had 2-4 nodules and 15 (7.2%) patients had 5 nodules, 29 (13.9%) of patients had the largest nodule less than 1 cm diameter. According to nodule nature, solid nodules were detected in 154 (73.7%), subsolid in 43 (25.6%) and ground glass in 12 (5.7%) patients and malignant histopathology was detected in 107 (69.5%), 37 (86%) and in 8 (66.6%) respectively. Among twenty-nine (13.9%) patients with subcentimetric nodules, 16 (61.5%) patients were diagnosed with malignancy. Thirty-three (15.8%) patients showed no avidity in PET-CT scan of whom 4 (12.1%) were diagnosed with adenocarcinoma metastasis. Totally, 185 (88.5%) surgical procedures were performed by video assisted thoracic surgery (VATS), 24 (11.5%) patients needed thoracotomy without mortality. Multivariate analysis showed that previous malignancy history (p<0.019), diameter of a nodule (>1 cm) (p<0.027), emphysema in lung parenchyma (p<0.003), high Brock risk score (p<0.011), high Herder risk score (p<0.001), increased avidity of PET scan (p<0.001) were risk factors for malignancy. Conclusion: Clinical scoring, radiological findings and patient history are important factors in the prediction of malignancy, but multidisciplinary follow-up, especially, in conflicting cases plays a critical role in terms of detecting malignancy. VATS is a safe surgical method that can be used for definitive diagnosis in these patients.

Keywords

References

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Details

Primary Language

English

Subjects

Surgery (Other)

Journal Section

Research Article

Authors

Shahab Ghivi This is me
3201-8202-1209-1336
Türkiye

Sehnaz Olgun
0000-0002-3236-3995
Türkiye

Caner Çınar ^*
0000-0003-3284-3945
Türkiye

Cansu Yıldız This is me
0000-0003-2522-5321
Türkiye

Derya Kocakaya
0000-0003-2910-6813
Türkiye

Nezih Onur Ermerak This is me
0000-0003-1939-3222
Türkiye

Emine Bozkurtlar
0000-0002-1034-9236
Türkiye

Özlem Demircioğlu
0000-0002-2408-7660
Türkiye

Hüseyin Arıkan
0000-0001-8837-2527
Türkiye

Feyza Şen
0000-0001-9451-4587
Türkiye

Özlem Ercelep
0000-0001-5892-3519
Türkiye

Cagatay Çimşit
0000-0003-4735-4140
Türkiye

Emel Eryüksel
0000-0002-2194-8066
Türkiye

Sait Karakurt
0000-0002-6699-5798
Türkiye

Bedrettin Yıldızeli
0000-0002-1316-4552
Türkiye

Publication Date

May 30, 2025

Submission Date

March 26, 2025

Acceptance Date

April 24, 2025

Published in Issue

Year 2025 Volume: 38 Number: 2

DOI

https://doi.org/10.5472/marumj.1708833

IZ

https://izlik.org/JA34EE69CA

Cite

RIS / Bibtex

APA

Ghivi, S., Olgun, S., Çınar, C., Yıldız, C., Kocakaya, D., Ermerak, N. O., Bozkurtlar, E., Demircioğlu, Ö., Arıkan, H., Şen, F., Ercelep, Ö., Çimşit, C., Eryüksel, E., Karakurt, S., & Yıldızeli, B. (2025). Clinical and radiological findings in relation to histopathological results of pulmonary nodule resections. Marmara Medical Journal, 38(2), 121-128. https://doi.org/10.5472/marumj.1708833

AMA

1.Ghivi S, Olgun S, Çınar C, et al. Clinical and radiological findings in relation to histopathological results of pulmonary nodule resections. Marmara Med J. 2025;38(2):121-128. doi:10.5472/marumj.1708833

Chicago

Ghivi, Shahab, Sehnaz Olgun, Caner Çınar, et al. 2025. “Clinical and Radiological Findings in Relation to Histopathological Results of Pulmonary Nodule Resections”. Marmara Medical Journal 38 (2): 121-28. https://doi.org/10.5472/marumj.1708833.

EndNote

Ghivi S, Olgun S, Çınar C, Yıldız C, Kocakaya D, Ermerak NO, Bozkurtlar E, Demircioğlu Ö, Arıkan H, Şen F, Ercelep Ö, Çimşit C, Eryüksel E, Karakurt S, Yıldızeli B (May 1, 2025) Clinical and radiological findings in relation to histopathological results of pulmonary nodule resections. Marmara Medical Journal 38 2 121–128.

IEEE

[1]S. Ghivi et al., “Clinical and radiological findings in relation to histopathological results of pulmonary nodule resections”, Marmara Med J, vol. 38, no. 2, pp. 121–128, May 2025, doi: 10.5472/marumj.1708833.

ISNAD

Ghivi, Shahab - Olgun, Sehnaz - Çınar, Caner - Yıldız, Cansu - Kocakaya, Derya - Ermerak, Nezih Onur - Bozkurtlar, Emine et al. “Clinical and Radiological Findings in Relation to Histopathological Results of Pulmonary Nodule Resections”. Marmara Medical Journal 38/2 (May 1, 2025): 121-128. https://doi.org/10.5472/marumj.1708833.

JAMA

1.Ghivi S, Olgun S, Çınar C, Yıldız C, Kocakaya D, Ermerak NO, Bozkurtlar E, Demircioğlu Ö, Arıkan H, Şen F, Ercelep Ö, Çimşit C, Eryüksel E, Karakurt S, Yıldızeli B. Clinical and radiological findings in relation to histopathological results of pulmonary nodule resections. Marmara Med J. 2025;38:121–128.

MLA

Ghivi, Shahab, et al. “Clinical and Radiological Findings in Relation to Histopathological Results of Pulmonary Nodule Resections”. Marmara Medical Journal, vol. 38, no. 2, May 2025, pp. 121-8, doi:10.5472/marumj.1708833.

Vancouver

1.Shahab Ghivi, Sehnaz Olgun, Caner Çınar, Cansu Yıldız, Derya Kocakaya, Nezih Onur Ermerak, Emine Bozkurtlar, Özlem Demircioğlu, Hüseyin Arıkan, Feyza Şen, Özlem Ercelep, Cagatay Çimşit, Emel Eryüksel, Sait Karakurt, Bedrettin Yıldızeli. Clinical and radiological findings in relation to histopathological results of pulmonary nodule resections. Marmara Med J. 2025 May 1;38(2):121-8. doi:10.5472/marumj.1708833