Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi

Elif Bahadır; Elif Bahadır; Muhammet Bulut; Beyza Kabayuka; Beyza Kabayuka; Ece Söylem Şenkal; Abdullah Avlaç; Meral Yüksel; Feriha Ercan; İnci Alican; İnci Alican

doi:10.5472/MMJoa.2901.01

Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi

Abstract

Amaç: Bu çalışmada sıçanlarda stres ile uyarılan mide ülserinde simvastatin’in (SİM) olası koruyucu etkisini değerlendirmek amaçlanmıştır. Gereç ve Yöntem: Sprague-Dawley sıçanlarda (250-300 gr) soğuk-kısıtlama stres uygulaması ile mide ülseri oluşturuldu. Stres öncesi 21 gün süreyle SİM (10 mg/kg/day; oral yolla) veya fizyolojik tuzlu su (1 ml; oral yolla) uygulandı. Bir grup sıçan 21. günde SİM öncesi selektif olmayan nitrik oksit sentaz (NOS) inhibitörü L-NAME (50 mg/kg; intraperitoneal) veya selektif olmayan siklooksijenaz (COX) inhibitörü indometazin (İndo; 5 mg/kg; subkutan) verildi. Mideler makroskopik ve mikroskopik olarak incelendi ve biyokimyasal analizler için saklandı. Bulgular: Stres grubunda lezyonların şiddeti SİM ile azaldı ancak L-NAME veya İndo ile anlamlı bir değişiklik göstermedi. Stres mide miyeloperoksidaz aktivitesini kontrol düzeyine kıyasla artırdı (p

Keywords

Ülser, Nitrik oksit sentaz, Siklooksijenaz, Sıçan, Stres

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Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Elif Bahadır This is me

Muhammet Bulut This is me

Beyza Kabayuka This is me

Ece Söylem Şenkal This is me

Abdullah Avlaç

Meral Yüksel This is me

Feriha Ercan This is me

İnci Alican

Publication Date

March 4, 2016

Submission Date

March 4, 2016

Acceptance Date

-

Published in Issue

Year 2016 Volume: 29 Number: 1

DOI

https://doi.org/10.5472/MMJoa.2901.01

IZ

https://izlik.org/JA34WX46TR

Cite

RIS / Bibtex

APA

Bahadır, E., Bahadır, E., Bulut, M., Kabayuka, B., Kabayuka, B., Şenkal, E. S., Avlaç, A., Yüksel, M., Ercan, F., Alican, İ., & Alican, İ. (2016). Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi. Marmara Medical Journal, 29(1), 1-7. https://doi.org/10.5472/MMJoa.2901.01

AMA

1.Bahadır E, Bahadır E, Bulut M, et al. Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi. Marmara Med J. 2016;29(1):1-7. doi:10.5472/MMJoa.2901.01

Chicago

Bahadır, Elif, Elif Bahadır, Muhammet Bulut, et al. 2016. “Sıçanda Stres Ile Uyarılan Mide ülserinde Simvastatin’in Etkisi”. Marmara Medical Journal 29 (1): 1-7. https://doi.org/10.5472/MMJoa.2901.01.

EndNote

Bahadır E, Bahadır E, Bulut M, Kabayuka B, Kabayuka B, Şenkal ES, Avlaç A, Yüksel M, Ercan F, Alican İ, Alican İ (March 1, 2016) Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi. Marmara Medical Journal 29 1 1–7.

IEEE

[1]E. Bahadır et al., “Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi”, Marmara Med J, vol. 29, no. 1, pp. 1–7, Mar. 2016, doi: 10.5472/MMJoa.2901.01.

ISNAD

Bahadır, Elif - Bahadır, Elif - Bulut, Muhammet - Kabayuka, Beyza - Kabayuka, Beyza - Şenkal, Ece Söylem - Avlaç, Abdullah et al. “Sıçanda Stres Ile Uyarılan Mide ülserinde Simvastatin’in Etkisi”. Marmara Medical Journal 29/1 (March 1, 2016): 1-7. https://doi.org/10.5472/MMJoa.2901.01.

JAMA

1.Bahadır E, Bahadır E, Bulut M, Kabayuka B, Kabayuka B, Şenkal ES, Avlaç A, Yüksel M, Ercan F, Alican İ, Alican İ. Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi. Marmara Med J. 2016;29:1–7.

MLA

Bahadır, Elif, et al. “Sıçanda Stres Ile Uyarılan Mide ülserinde Simvastatin’in Etkisi”. Marmara Medical Journal, vol. 29, no. 1, Mar. 2016, pp. 1-7, doi:10.5472/MMJoa.2901.01.

Vancouver

1.Elif Bahadır, Elif Bahadır, Muhammet Bulut, Beyza Kabayuka, Beyza Kabayuka, Ece Söylem Şenkal, Abdullah Avlaç, Meral Yüksel, Feriha Ercan, İnci Alican, İnci Alican. Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi. Marmara Med J. 2016 Mar. 1;29(1):1-7. doi:10.5472/MMJoa.2901.01