Autopsy report of Dandy-Walker malformation: A rare anomaly of the brain

Year 2026, Volume: 39 Issue: 1, 80 - 84, 28.01.2026

Nikita Patil , Manasi Gosavi Ashwini Ratnakar

https://doi.org/10.5472/marumj.1873584

Abstract

Dandy-Walker malformation is a rare congenital anomaly of the posterior fossa of the skull and cerebellum. The pathology includes
hypoplasia or agenesis of the vermis of the cerebellum, cystically dilated fourth ventricle, and an enlarged posterior fossa of the skull.
This anomaly of the cerebellum can lead to a wide spectrum of clinical presentations ranging from mild developmental delay to severe
hydrocephalus, seizures, and fatality. It is usually diagnosed prenatally using anomaly scans. A detailed study of morphological and
microscopic findings is necessary for a better understanding of the etiopathogenesis of this anomaly.
Autopsy is considered the gold standard for confirmation of findings associated with this anomaly. It can also help to explore other
associated anomalies which can further help in genetic studies and patient counseling.
Herein, we present an autopsy report of a 20-week-old male fetus with Dandy-Walker malformation diagnosed prenatally and sent for
autopsy with informed consent after medical termination of pregnancy. Gross and microscopic findings were studied and compared
with those of previous studies done in the past.

Keywords

Dandy-Walker , Vermis , Ventricle , Cerebellum

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