Araştırma Makalesi
BibTex RIS Kaynak Göster

Seton drainage combined with anti-tnf therapy for perianal fistulizing Crohn’s disease, single center experience

79 - 83, 15.05.2016

Samet Yardımcı , Yalçın Kara Wafi Attaallah Mustafa Uğurlu Şevket Yeğen

https://doi.org/10.5472/MMJoa.2902.03
Cited By: 1

Öz

Kaynakça

  • Molendijk I, Peeters KC, Baeten CI, Veenendaal RA, van der Meulen-de Jong AE. Improving the outcome of fistulising Crohn’s disease. Best Pract Res Clin Gastroenterol 2014; 28: 505-18. doi: 10.1016/j.bpg.2014.04.011.
  • Kamm MA, Ng SC. Perianal fistulizing Crohn’s disease: a call to action. Clin Gastroenterol Hepatol 2008 ; 6: 7–10.
  • Van Assche G, Dignass A, Reinisch W, et al. The second European evidence-based consensus on the diagnosis and management of Crohn’s disease: special situations. J Crohn’s Colitis 2010; 4: 63–101. doi:10.1016/j.crohns.2009.09.009
  • Sandborn WJ, Fazio VW, Feagan BG, Hanauer SB. AGA technical review on perianal Crohn’s disease. Gastroenterology 2003; 125: 1508–30.
  • Lunniss PJ, Armstrong P, Barker PG, Reznek RH, Phillips RK. Magnetic resonance imaging of anal fistulae. Lancet 1992; 15: 394–6.
  • Orsoni P, Barthet M, Portier F, Panuel M, Desjeux A, Grimaud JC. Prospective comparison of endosonography, magnetic resonance imaging and surgical findings in anorectal fistula and abscess complicating Crohn’s disease. Br J Surg 1999; 86: 360–4.
  • Schwartz DA, Wiersema MJ, Dudiak KM, et al. A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn’s perianal fistulas. Gastroenterology 2001; 121: 1064–72.
  • Parks AG, Gordon PH, Hardcastle JD. A classification of fistula-in-ano. Br J Surg 1976; 63: 1–12.
  • Gecse K, Khanna R, Stoker J, et al. Fistulizing Crohn’s disease: Diagnosis and management. United European Gastroenterol J 2013; 1: 206-13. doi: 10.1177/2050640613487194
  • Yamamoto T, Allan RN, Keighley MRB. Effect of fecal diversion alone on perianal Crohn’s disease. World J Surg 2000; 24: 1258- 63.
  • Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn’s disease. N Engl J Med 1999; 340: 1398–405.
  • Sands BE, Anderson FH, Bernstein CN, et al. Infliximab maintenance therapy for fistulizing Crohn’s disease. N Engl J Med 2004; 350: 876–85.
  • Da W, Zhu J, Wang L, Lu Y. Adalimumab for Crohn’s disease after infliximab treatment failure: a systematic review. Eur J Gastroenterol Hepatol 2013; 25: 885-91. doi: 10.1097/MEG.0b013e32836220ab
  • Rasul I, Wilson SR, MacRae H, Irwin S, Greenberg GR. Clinical and radiological responses after infliximab treatment for perianal fistulizing Crohn’s disease. Am J Gastroenterol 2004; 99: 82-8.
  • Haennig A, Staumont G, Lepage B, et al. The results of seton drainage combined with anti TNFα therapy for anal fistula in Crohn’s disease. Colorectal Dis 2015; 17: 311-9.
  • Topstad DR, Panaccione R, Heine JA, Johnson DRE, MacLean AR, Buie WD. Combined seton placement, infliximab infusion, and maintenance immunosuppressives improve healing rate in fistulizing anorectal Crohn’s disease. A single center experience. Dis Colon Rectum 2003; 46: 577–83.
  • Tougeron D, Savoye G, Savoye-Collet C, Koning E, Michot F, Lerebours E. Predicting factors of fistula healing and clinical remission after infliximab based combined therapy for perianal fistulizing Crohn’s disease. Dig Dis Sci 2009; 54: 1746- 52.
  • Talbot C, Sagar PM, Johnston MJ, Finan PJ, Burke D. Infliximab in the surgical management of complex fistulating anal Crohn’s disease. Colorectal Dis 2005; 7: 164-8. doi: 10.1111/j.1463-1318.2004.00749.x
  • Hyder SA, Travis SP, Jewell DP, McC Mortensen NJ, George BD. Fistulating anal Crohn’s disease: results of combined surgical and infliximab treatment. Dis Colon Rectum 2006; 49: 1837-41.
  • Guidi L, Ratto C, Semeraro S, et al. Combined therapy with infliximab and seton drainage for perianal fistulizing Crohn’s disease with anal endosonographic monitoring: a single-centre experience. Tech Coloproctol 2008; 12: 111-7.
  • Bouguen G, Trouilloud I, Siproudhis L, et al. Long-term outcome of non-fistulizing (ulcers, stricture) perianal Crohn’s disease in patients treated with infliximab. Aliment Pharmacol Ther 2009; 30: 749-56.
  • Duff S, Sagar PM, Rao M, Dolling S, Sprakes M, Hamlin PJ. Infliximab and surgical treatment of complex anal Crohn’s disease. Colorectal Dis 2012; 14: 972-6.
  • Antakia R, Shorthouse AJ, Robinson K, Lobo AJ. Combined modality treatment for complex fistulating perianal Crohn’s disease. Colorectal Dis 2013; 15: 210-6.
  • Bouguen G, Siproudhis L, Gizard E, et al. Long-term outcome of perianal fistulizing Crohn’s disease treated with infliximab. Clin Gastroenterol Hepatol 2013; 11: 975-81. doi: 10.1016/j.cgh.2012.12.042.

Perianal fistulizan Crohn hastalığında combine seton drenaj ve anti-TNF tedavi sonuçları, tek merkez deneyimi

79 - 83, 15.05.2016

Samet Yardımcı , Yalçın Kara Wafi Attaallah Mustafa Uğurlu Şevket Yeğen

https://doi.org/10.5472/MMJoa.2902.03
Cited By: 1

Öz

Amaç: Bu çalışmanın amacı perianal Crohn hastalığında, kombine seton ve anti tümör nekroz faktörü (TNF) ajanlarla yapılan tedavinin etkinliğini değerlendirmektir. Hastalar ve Yöntem: Ocak 2013 ve Kasım 2014 tarihleri arasında kombine seton drenaj ve anti-TNF tedavisi uygulanmış ardışık 27 perianal fistülizan Crohn hastası çalışmaya dahil edildi. Tüm hastalar standart pelvik manyetik rezonans görüntüleme (MRG) ile incelendi. Hasta özellikleri, takip zamanı, pelvik MRG bulguları, kolonoskopi ve genel anestezi altında rektal muayene bulguları, kaydedildi. Takip süresinin sonunda tedaviye yanıt değerlendirildi. Bulgular: Tedavi sonrası ortanca takip süresi 17 ay idi. Hastaların 24 (%89)’ünde fistül kompleks yapıda idi. Kolonoskopi bulgularına göre 16 (%59,3) hastada ileit, 9 (%33,3) hastada aktif proktit saptandı. On iki (%44,4) hastada perianal apse gözlendi. Tedaviye tam yanıt 17 hastada elde edilirken, çalışma sürecinde sadece 3 (%11,1) hastada tekrarlayan perianal apse ile karşılaşıldı. Değerlendirdiğimiz faktörlerden hiçbiri komplet yanıt ile anlamlı olarak ilişkili bulunmadı. Sonuç: Crohn hastalığı ile ilişkili kompleks perianal fistülde kombine seton ve anti-TNF tedavi ile hastaların % 63’ünde tedaviye tam yanıt sağlanmıştır

Anahtar Kelimeler

Crohn hastalığı Perianal fistül Seton Infliximab

Kaynakça

  • Molendijk I, Peeters KC, Baeten CI, Veenendaal RA, van der Meulen-de Jong AE. Improving the outcome of fistulising Crohn’s disease. Best Pract Res Clin Gastroenterol 2014; 28: 505-18. doi: 10.1016/j.bpg.2014.04.011.
  • Kamm MA, Ng SC. Perianal fistulizing Crohn’s disease: a call to action. Clin Gastroenterol Hepatol 2008 ; 6: 7–10.
  • Van Assche G, Dignass A, Reinisch W, et al. The second European evidence-based consensus on the diagnosis and management of Crohn’s disease: special situations. J Crohn’s Colitis 2010; 4: 63–101. doi:10.1016/j.crohns.2009.09.009
  • Sandborn WJ, Fazio VW, Feagan BG, Hanauer SB. AGA technical review on perianal Crohn’s disease. Gastroenterology 2003; 125: 1508–30.
  • Lunniss PJ, Armstrong P, Barker PG, Reznek RH, Phillips RK. Magnetic resonance imaging of anal fistulae. Lancet 1992; 15: 394–6.
  • Orsoni P, Barthet M, Portier F, Panuel M, Desjeux A, Grimaud JC. Prospective comparison of endosonography, magnetic resonance imaging and surgical findings in anorectal fistula and abscess complicating Crohn’s disease. Br J Surg 1999; 86: 360–4.
  • Schwartz DA, Wiersema MJ, Dudiak KM, et al. A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn’s perianal fistulas. Gastroenterology 2001; 121: 1064–72.
  • Parks AG, Gordon PH, Hardcastle JD. A classification of fistula-in-ano. Br J Surg 1976; 63: 1–12.
  • Gecse K, Khanna R, Stoker J, et al. Fistulizing Crohn’s disease: Diagnosis and management. United European Gastroenterol J 2013; 1: 206-13. doi: 10.1177/2050640613487194
  • Yamamoto T, Allan RN, Keighley MRB. Effect of fecal diversion alone on perianal Crohn’s disease. World J Surg 2000; 24: 1258- 63.
  • Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn’s disease. N Engl J Med 1999; 340: 1398–405.
  • Sands BE, Anderson FH, Bernstein CN, et al. Infliximab maintenance therapy for fistulizing Crohn’s disease. N Engl J Med 2004; 350: 876–85.
  • Da W, Zhu J, Wang L, Lu Y. Adalimumab for Crohn’s disease after infliximab treatment failure: a systematic review. Eur J Gastroenterol Hepatol 2013; 25: 885-91. doi: 10.1097/MEG.0b013e32836220ab
  • Rasul I, Wilson SR, MacRae H, Irwin S, Greenberg GR. Clinical and radiological responses after infliximab treatment for perianal fistulizing Crohn’s disease. Am J Gastroenterol 2004; 99: 82-8.
  • Haennig A, Staumont G, Lepage B, et al. The results of seton drainage combined with anti TNFα therapy for anal fistula in Crohn’s disease. Colorectal Dis 2015; 17: 311-9.
  • Topstad DR, Panaccione R, Heine JA, Johnson DRE, MacLean AR, Buie WD. Combined seton placement, infliximab infusion, and maintenance immunosuppressives improve healing rate in fistulizing anorectal Crohn’s disease. A single center experience. Dis Colon Rectum 2003; 46: 577–83.
  • Tougeron D, Savoye G, Savoye-Collet C, Koning E, Michot F, Lerebours E. Predicting factors of fistula healing and clinical remission after infliximab based combined therapy for perianal fistulizing Crohn’s disease. Dig Dis Sci 2009; 54: 1746- 52.
  • Talbot C, Sagar PM, Johnston MJ, Finan PJ, Burke D. Infliximab in the surgical management of complex fistulating anal Crohn’s disease. Colorectal Dis 2005; 7: 164-8. doi: 10.1111/j.1463-1318.2004.00749.x
  • Hyder SA, Travis SP, Jewell DP, McC Mortensen NJ, George BD. Fistulating anal Crohn’s disease: results of combined surgical and infliximab treatment. Dis Colon Rectum 2006; 49: 1837-41.
  • Guidi L, Ratto C, Semeraro S, et al. Combined therapy with infliximab and seton drainage for perianal fistulizing Crohn’s disease with anal endosonographic monitoring: a single-centre experience. Tech Coloproctol 2008; 12: 111-7.
  • Bouguen G, Trouilloud I, Siproudhis L, et al. Long-term outcome of non-fistulizing (ulcers, stricture) perianal Crohn’s disease in patients treated with infliximab. Aliment Pharmacol Ther 2009; 30: 749-56.
  • Duff S, Sagar PM, Rao M, Dolling S, Sprakes M, Hamlin PJ. Infliximab and surgical treatment of complex anal Crohn’s disease. Colorectal Dis 2012; 14: 972-6.
  • Antakia R, Shorthouse AJ, Robinson K, Lobo AJ. Combined modality treatment for complex fistulating perianal Crohn’s disease. Colorectal Dis 2013; 15: 210-6.
  • Bouguen G, Siproudhis L, Gizard E, et al. Long-term outcome of perianal fistulizing Crohn’s disease treated with infliximab. Clin Gastroenterol Hepatol 2013; 11: 975-81. doi: 10.1016/j.cgh.2012.12.042.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Konular Klinik Tıp Bilimleri
Bölüm Makaleler
Yazarlar

Samet Yardımcı

Yalçın Kara Bu kişi benim

Wafi Attaallah Bu kişi benim

Mustafa Uğurlu Bu kişi benim

Şevket Yeğen Bu kişi benim

Yayımlanma Tarihi 15 Mayıs 2016
Yayımlandığı Sayı Yıl 2016

Kaynak Göster

APA Yardımcı, S., Kara, Y., Attaallah, W., Uğurlu, M., vd. (t.y.). Seton drainage combined with anti-tnf therapy for perianal fistulizing Crohn’s disease, single center experience. Marmara Medical Journal, 29(2?), 79-83. https://doi.org/10.5472/MMJoa.2902.03
AMA Yardımcı S, Kara Y, Attaallah W, Uğurlu M, Yeğen Ş. Seton drainage combined with anti-tnf therapy for perianal fistulizing Crohn’s disease, single center experience. Marmara Med J. 29(2?):79-83. doi:10.5472/MMJoa.2902.03
Chicago Yardımcı, Samet, Yalçın Kara, Wafi Attaallah, Mustafa Uğurlu, ve Şevket Yeğen. “Seton Drainage Combined With Anti-Tnf Therapy for Perianal Fistulizing Crohn’s Disease, Single Center Experience”. Marmara Medical Journal 29, sy. 2? t.y.: 79-83. https://doi.org/10.5472/MMJoa.2902.03.
EndNote Yardımcı S, Kara Y, Attaallah W, Uğurlu M, Yeğen Ş Seton drainage combined with anti-tnf therapy for perianal fistulizing Crohn’s disease, single center experience. Marmara Medical Journal 29 2? 79–83.
IEEE S. Yardımcı, Y. Kara, W. Attaallah, M. Uğurlu, ve Ş. Yeğen, “Seton drainage combined with anti-tnf therapy for perianal fistulizing Crohn’s disease, single center experience”, Marmara Med J, c. 29, sy. 2?, ss. 79–83, doi: 10.5472/MMJoa.2902.03.
ISNAD Yardımcı, Samet vd. “Seton Drainage Combined With Anti-Tnf Therapy for Perianal Fistulizing Crohn’s Disease, Single Center Experience”. Marmara Medical Journal 29/2? (t.y.), 79-83. https://doi.org/10.5472/MMJoa.2902.03.
JAMA Yardımcı S, Kara Y, Attaallah W, Uğurlu M, Yeğen Ş. Seton drainage combined with anti-tnf therapy for perianal fistulizing Crohn’s disease, single center experience. Marmara Med J.;29:79–83.
MLA Yardımcı, Samet vd. “Seton Drainage Combined With Anti-Tnf Therapy for Perianal Fistulizing Crohn’s Disease, Single Center Experience”. Marmara Medical Journal, c. 29, sy. 2?, ss. 79-83, doi:10.5472/MMJoa.2902.03.
Vancouver Yardımcı S, Kara Y, Attaallah W, Uğurlu M, Yeğen Ş. Seton drainage combined with anti-tnf therapy for perianal fistulizing Crohn’s disease, single center experience. Marmara Med J. 29(2?):79-83.

Cited By

https://doi.org/