ENDOKRİN HASTALIKLARDA ASİMETRİK DİMETİLARJİNİN (ADMA)

Abstract

Asimetrik dimetilarjinin (ADMA) insanda nitrik oksit biyosentezinin majör inhibitörüdür. Yapılan son çalışmalarda plazma ADMA düzeylerindeki artışın endotel disfonksiyonu ve artmış aterogenez ile ilişkili olduğu gösterilmiştir. Birçok endokrin hastalıkta kardiyovasküler riske katkıda bulunan artmış ADMA düzeyleri saptanmıştır. Bu derleme yazısında ADMA’nın diabetes mellitus, obezite ve tiroid disfonksiyonu gibi çeşitli endokrin hastalıklardaki rolü tartışılacaktır.

Anahtar Kelimeler: ADMA, NO, endokrin hastalıklar, kardiyovasküler risk

Keywords

• ADMA, NO, Endokrin hastalıklar, Kardiyovasküler risk

References

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