METOKLOPRAMİDE BAĞLI AKUT DİSTONİK REAKSİYON: İKİ OLGU SUNUMU

Abstract

Metoklopramid, çocukluk çağında yaygın olarak kullanılan antiemetik bir ajan olup, en sık görülen yan etkisi ekstrapiramidal reaksiyonlardır. Çocuklarda insidansı % 0.5-1 iken, adölesan ve yaşlılarda % 25 civarındadır. Hastalar, meninjit, ensefalit, hipokalsemi, nöbet ve tetanoz şeklinde yanlış tanı alabilmektedir. Biz de ensefalit ön tanısı ile hastanemize sevk edilen 8 aylık ve 10 yaşında iki erkek hastada, metoklopramide bağlı akut distonik reaksiyon gelişen iki vaka saptadık.

Anahtar Kelimeler: Metoklopramid, akut distonik reaksiyon, çocuklar

Keywords

• Metoklopramid, akut distonik reaksiyon, çocuklar

References

1. Miller LG, Jankovic J. Metoclopramide-induced
2. movement disorders: clinical findings with a review
3. of the literature. Arch Intern Med 1989; 149: 2486-
4. -
5. Grimes JD, Hassan MN, Preston DN. Adverse
6. neurologic effects of metoclopramide. Can Med
7. Assoc J 1982; 26: 23-25.
8. Hagen EM, Farbu E, Bindoff L. Acute dystonia

9. caused by metoclopramide theraphy. Tidsskr Nor
10. Laegeforen 2001; 121: 2162-2163.
11. Allen JC, Gralla R, Reilly L, Kellick M, Young C.
12. Metoclopramide: dose related toxicity and
13. preliminary antiemetic studies in children receiving
14. cancer chemotheraphy. J Clin Oncol 1985; 3: 1136-
15. -
16. Herbst JJ. Gastroesophageal Reflux (15th ed).
17. Saunders Company, Philadelphia 1996, pp 1055-
18. -
19. Carey MJ, Aitken ME. Diverse effects of antiemetics
20. in chilren. N Z Med J 1994; 9: 452-453.
21. Ponte CD, Nappi JM. Review of a new
22. gastrointestinal drug metoclopramide. Am J Hosp
23. Pharm 1981; 38: 829-833.
24. Matson JL, Mayville EA, Bieleck J, Sınalls Y,
25. Eckholdt CS. Tardive dyskinesia associated with
26. metoclopramide in persons with developmental
27. disabilities. Res Dev Disabil 2002; 23: 224-233.
28. Tait PA. Supraglottic dystonic reaction to
29. metoclopramide in a child. Med J Aust 2001; 174:
30. -608.
31. Putnam PE, Orenstein SR, Wessel HB, Stowe RM.
32. Tardive dyskinesia associated with use of
33. metoclopramide in a child. J Pediatr 1992; 121: 983-
34. -
35. Cezard C, Nisse P, Quaranta S, Peucelle D, MathieuNolf
36. M. Acute dystonia from metoclopramide in
37. children. Therapie 2003; 58: 367-370.
38. Bophale S, Seidel JS. Dystonic reaction to a
39. phenothiazine presenting as Bell’s palsy. Ann Emerg
40. Med 1997; 30: 234-236.
41. Vernon MG. Drug induced tardive movement
42. disorders. J Neuroscience Nursing 1991; 23: 183-187.
43. Yis U, Ozdemir D, Duman M, Unal N.
44. Metoclopramide induced dystonia in children: two
45. case reports. Eur J Emerg Med 2005; 12: 117-119.