Investigation of the effects of probiotics on allergy

Yıl 2018, , 11 - 16, 26.02.2018

Rabia Can Sarınoğlu Buket Cicioğlu Arıdoğan

https://doi.org/10.5472/marumj.398839

Öz

Objectives: To investigate the effects of a probiotic mixture that

was isolated from human gut flora, and a standard probiotic strain

Lactobacillus GG (LGG) on allergic immune responses in an

animal model.

Materials and Methods: Three Enterococcus faecalis, 8

Lactobacillus plantarum, and 2 Lactobacillus rhamnosus strains

were included in the mixture. Balb-c mice in the study groups

were given the probiotic mixture, and standard strain LGG, and

animals in the control groups were given skimmed milk for 28

days. The mice in the study groups and the positive control group

were immunized with an intraperitoneal injection of ovalbumin

(OVA) on days 14 and 21. An enzyme-linked immunosorbent

assay was used to study the OVA-specific IgE levels in the mice

serums.

Results: The most remarkable results were that OVAspecific

IgE levels were significantly higher (P<0.001) in

the positive control group compared with the nonimmunized

negative control group, and OVA-specific IgE levels in the

study groups were significantly lower than the positive control

group (P<0.001).

Conclusion: The data of the present study suggest that

oral administration of probiotics prevents IgE-mediated OVAhypersensitivity;

however, the immunoregulatory effects of

strains must be described in detail while preparing probiotic

mixtures.

Anahtar Kelimeler

Probiotics, Hypersensitivity, Lactobacillus

Kaynakça

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