A case of Krukenberg tumor, eight years after treatment of gastric cancer

Yıl 2018, , 81 - 84, 05.06.2018

Servet Karagül Fatih Sümer Asım Onur Ali Tardu Adile Ferda Dağlı Cuneyt Kayaalp

https://doi.org/10.5472/marumj.430802

Öz

Krukenberg tumor is a rare metastatic tumor of the ovary. The

primary tumors are usually gastrointestinal cancers. Most of the

Krukenberg tumors reported in the literature occurred within the

first 2 years after treatment of the primary disease. Herein, we

present a case of Krukenberg tumor in a 37-year-old woman who

previously underwent surgery and chemotherapy for stomach

cancer. This patient is noteworthy because it is one of the few

documented cases of ovarian metastasis appearing after a diseasefree

period of 8 years following treatment of the primary tumor.

Krukenberg tumors are associated with poor prognosis; therefore,

regular gynecological examination in female patients with history

of gastric cancer is very important for the early diagnosis and

treatment of this disease.

Anahtar Kelimeler

Krukenberg tumor, Gastric cancer, Ovarian metastasis

Mide kanseri tedavisinden 8 yıl sonra gelişen Krukenberg tümörü olgusu

Öz

Krukenberg tümörü overleri tutan, nadir görülen metastatik bir

tümördür. Sıklıkla primer odak gastrointestinal kanserlerdir.

Literatürdeki Krukenberg tümörlerinin çoğunluğu primer

hastalığın tedavisinden sonra ilk 2 yıl içinde meydana gelmektedir.

Biz burada mide kanseri nedeniyle cerrahi tedavi ve kemoterapi

uygulanmış 37 yaşında bir kadın hastada karşılaştığımız

Krukenberg olgusunu sunduk. Olgumuzun dikkat çeken tarafı

primer hastalığın tedavisinden sonra hastalıksız geçen 8 yılın

ardından over metastazı görülmesi olup, literatürdeki nadir

olgulardan biridir. Mide kanserli kadın hastalarda düzenli

jinekolojik muayene, prognozu oldukça kötü olan bu hastalığın

erken tanı ve tedavisi açısından önemlidir.

Anahtar Kelimeler

Krukenberg tümörü, Mide kanseri, Over metastazı

Kaynakça

• Kubecek O, Laco J, Spacek J, et al. The pathogenesis, diagnosis, and management of metastatic tumors to the ovary: a comprehensive review. Clin Exp Metastasis 2017; 34 : 295- 307. doi: 10.1007/s10585-017-9856-8
• Krukenberg F E. Fibrosarcoma ovarii mucocellulare (carcinomatodes). Arch Gynäkol 1896; 50: 287-321. doi: 10.1007/BF01700650
• Schlagenhaufer F. Ueber das metastatische ovarial carcinom nach Krebs des Magens, Darmes, und anderer Bauchorgane. Monatschr Gebursth Gynakol 1902;1:485-528ç doi: 10.1159/000283419
• Young RH. From Krukenberg to today: part I. Historical perspective, general principles, mucinous tumors including the Krukenberg tumor. Adv Anat Pathol 2006; 13: 205-7. doi: 10.1097/01.pap.0000213038.85704.e4
• Malgorzata J, Janusz E. Krukenberg tumor—8 years after surgical treatment of gastric carcinoma. Ginekol Pol 2008; 79: 564-6.
• Szarmach A, Swieton D, Szydlowska-Szarmach E, et al. Krukenberg tumor—a multidisciplinary approach—a case report. Ginekol Pol 2014; 85: 545-8.
• Li W, Wang H, Wang J, Fangfang LV, Zhu X, Wang Z. Ovarian metastases resection from extragenital primary sites: outcome and prognostic factor analysis of 147 patients. BMC Cancer 2012; 12: 278. doi:10.1186/1471-2407-12-278
• Aziz M, Kasi A. Cancer, Krukenberg Tumor. StatPearls [Internet].Treasure Island (FL): StatPearls Publishing; 2018. [Access on 14.03.2018]
• Matsushita H, Watanabe K, Wakatsuki A. Metastatic gastric cancer to the female genital tract. Mol Clin Oncol 2016; 5: 495-9. doi: 10.3892/mco.2016.1035
• Wu F, Zhao X, Mi B, et al. Clinical characteristics and prognostic analysis of Krukenberg tumor. Mol Clin Oncol 2015; 3: 1323-8. doi: 10.3892/mco.2015.634
• Nakamura Y, Hiramatsu A, Koyama T, Oyama Y, Tanaka A, Honma K. A krukenberg tumor from an occult intramucosal gastric carcinoma identified during an autopsy. Case Rep Oncol Med 2014; 2014: 797429. doi: 10.1155/2014/797429
• Kakushima N, Kamoshida T, Hirai S, et al. Early gastric cancer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor. J Gastroenterol 2003; 38: 1176-80. doi:10.1007/s00535-003-1227-3
• Yu P, Huang L, Cheng G, et al. Treatment strategy and prognostic factors for Krukenberg tumors of gastric origin: report of a 10-year single-center experience from China. Oncotarget 2017; 8: 82558-70. doi: 10.18632/ oncotarget.19759