A rare cutaneous lesion in the neonatal period: The non-Langerhans cell histiocytosis

Abstract

The non-Langerhans cell histiocytosis (non-LCH) is a group of diseases characterized by cutaneous involvement in the neonatal period. The non-LCH affects less than 1 in 200,000 children born each year. A definitive diagnosis is important for the treatment of the disease. Therefore, skin biopsies should be performed in neonates with cutaneous lesions as early as possible. Only in the presence of cutaneous involvement without systemic involvement, it does not require any treatment, because the lesions can mostly self-heal. Here, we present a neonate diagnosed with non-LCH following a skin biopsy. Keywords: Histiocytic disorders, Neonatal, non-Langerhans cell histiocytosis

Keywords

• Histiocytic disorders
• Neonatal
• non-Langerhans cell histiocytosis

References

1. Minkov M, Prosch H, Steiner M, et al. Langerhans cell histiocytosis in neonates. Pediatr Blood Cancer 2005;45:802- 7. doi: 10.1002/pbc.20362
2. Hart Isaacs, Jr. Fetal and neonatal histiocytoses. Pediatr Blood Cancer 2006;47:123-129. doi: 10.1002/pbc.20725
3. Classen CF, Minkov M, Lehrnbecher T. The non Langerhans cell histiocytoses (Rare histiocytoses) – Clinical aspects and therapeutic approaches. Klin Pediatr 2016; 228(6-07):294-306. doi: 10.1055/s0042-109713.
4. Walia M, Paul P, Mishra S, Mehta R. Congenital Langerhans cell histiocytosis: The self-healing variety. J Pediatr Hematol Oncol 2004;26:398-402. doi: 10.1097/00043.426.200406000- 00014
5. Haroche J, Abla O. Uncommon histiocytic disorders: Rosai- Dorfman, juvenile xanthogranuloma, and Erdheim-Chester disease. Hematology. Am Soc Hematol Educ Program 2015; 2015:571-8. doi: 10.1182/ asheducation-2015.1.571.
6. Divaris DX, Ling FC, Prentice RS. Congenital self-healing histiocytosis. Report of two cases with histochemical and ultrastructural studies. Am J Dermatopathol 1991;13:481-7.
7. Stein SL, Paller AS, Haut PR, et al. Langerhans cell histiocytosis presenting in the neonatal period: A retrospective case series. Arch Pediatr Adolesc Med 2001;155:778-83. doi:10.1001/ archpedi.155.7.778
8. Rivera-Luna R, Alter-Molchadsky N, Cardenas-Cardos R, et al. Langerhans cell histiocytosis in children under 2 years of age. Med Pediatr Oncol 1996;26:334-43. doi:10.1002/ (SICI)1096-911X(199605)26:5<334::AID-MPO6>3.0.CO;2-J

9. Huang F, Arceci R. The histiocytoses of infancy. Semin Perinatol 1999;23:319-31. doi: 10.1016/s0146-0005(99)80040-8
10. Weitzman S, Jaffe R. Uncommon histiocytic disorders: The non-Langerhans cell histiocytoses. Pediatr Blood Cancer 2005;44:1–9. doi: 10.1002/pbc.20246
11. Mahajan VK, Sharma AL, Chauhan PS, Mehta KS, Sharma V, Sharma S. Xanthoma disseminatum: a red herring xanthomatosis. Indian J Dermatol Venereol Leprol 2013;79:253-4. doi: 10.4103/0378-6323.107655. PMID: 23442474.
12. Arico M, Danesino C, Pende D, et al. Pathogenesis of haemophagocytic lymphohistiocytosis. Br J Haematol 2001;114:761–769. doi: 10.1046/j.1365-2141.2001.02936.x